The Transfer of Immunity with Macrophage RNA

  • Joel W. Goodman


The origin of the currently accepted doctrine that interplay between more than one type of cell is involved in the induction of the immune response can be traced to descriptions a decade ago of the transfer of immunity with RNA-rich extracts from cells exposed for short periods of time to antigen (Fishman, 1961; Fishman and Adler, 1963). This ancestry is peculiarly ironic in that the interpretation of those early experiments as a cooperative effect is more suspect now than then, albeit a considerable number of investigators have since taken up the gauntlet.


Keyhole Limpet Hemocyanin Peritoneal Cell Peritoneal Exudate Minor Band Antibody Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Adams, A., Lindahl, T., and Fresco, J. R. (1967). Proc. Natl. Acad. Sci. 55:1684.Google Scholar
  2. Adler, F. L., Fishman, M., and Dray, S. (1966). J. Immunol. 97: 554.Google Scholar
  3. Alexander, P., DeLorme, E. J., Hamilton, L. D. G., and Hall, J. G. (1967). Nature (Lond.) 213: 569.CrossRefGoogle Scholar
  4. Askonas, B. A., and Rhodes, J. M. (1965). Nature (Lond.) 205: 470.CrossRefGoogle Scholar
  5. Bell, C., and Dray, S. (1969). J. Immunol. 103: 1196.PubMedGoogle Scholar
  6. Bell, C., and Dray, S. (1970). J. Immunol. 105: 541.PubMedGoogle Scholar
  7. Bell, C., and Dray, S. (1971). Science 171: 199.PubMedCrossRefGoogle Scholar
  8. Bluestein, H. G., Green, I., and Benacerraf, B. (1970). Proc. Soc. Exptl. Biol. Med. 135: 146.Google Scholar
  9. Burdon, R. H. (1967). J. Mol. Biol. 30: 571.PubMedGoogle Scholar
  10. Cramer, F., Doepner, H., Haar, F. V. D., and Schlimme, E. (1968). Proc. Natl. Acad. Sci. 61: 1384.PubMedCrossRefGoogle Scholar
  11. Egan, M.L., Smyth, R. D., and Maurer, P. H. (1971). J. Immunol. 107: 540.PubMedGoogle Scholar
  12. Fishman, M. (1961). J. Exptl. Med. 114: 837.CrossRefGoogle Scholar
  13. Fishman, M., and Adler, F. L. (1963). J. Exptl. Med. 117: 595.CrossRefGoogle Scholar
  14. Friedman, H. P., Stavitsky, A. B., and Solomon, J. M. (1965). Science 149: 1106.Google Scholar
  15. Gallily, R., and Feldman, M. (1967). Immunology 12: 197.PubMedGoogle Scholar
  16. Garvey, J. S., Kinderknecht, H., and Weliky, B. (1970). Fed. Proc. 29: 376.Google Scholar
  17. Goodman, J. W. (1969), Immunochemistry 6: 139.PubMedCrossRefGoogle Scholar
  18. Gottlieb, A. A. (1968). In Plescia, O. J., and Braun, W. (eds.), Nucleic Acids in Immunology, Springer-Verlag, New York, p. 471.CrossRefGoogle Scholar
  19. Gottlieb, A. A. (1969). Biochemistry 8: 2111.Google Scholar
  20. Gottlieb, A. A. (1971). In Beers, R. E., and Braun, W. (eds.), Biological Effects of Polynucleotides, Springer-Verlag, New York, p. 293.CrossRefGoogle Scholar
  21. Gottlieb, A. A., Glisin, V. R., and Doty, P. (1967). Proc. Natl. Acad. Sci. 57:1949.Google Scholar
  22. Gowans, J. C., and McGregor, D. D. (1965). Progr. Allergy 9: 1.Google Scholar
  23. Haskill, J. S., Byrt, P., and Marbrook, J. (1970). J. Exptl. Med. 131: 57.CrossRefGoogle Scholar
  24. Jureziz, R. E., Thor, D. E., and Dray, S. (1968). J. Immunol. 101: 823.PubMedGoogle Scholar
  25. Jureziz, R. E., Thor, D. E., and Dray, S. (1970). J. Immunol. 105: 1313.PubMedGoogle Scholar
  26. Kölsch, E., and Mitchison, N. A. (1968). J. Exptl. Med. 128: 1059.Google Scholar
  27. Laycock, D. G., and Hunt, J. A. (1969). Nature (Lond.) 222: 1118.Google Scholar
  28. Lindahl, T., Adams, A., and Fresco, J. R. (1966). Proc. Natl. Acad. Sci. 55: 941.PubMedCrossRefGoogle Scholar
  29. Liu, W. I., and Wang, P. T. (1964). Sci Sim. 13: 463.Google Scholar
  30. Lockard, R., and Lingrel, J. B. (1969). Biochem. Biophys. Res. Commun. 37: 204.PubMedCrossRefGoogle Scholar
  31. Mach, B. (1968). In Williams, C. A., and Chase, M. W. (eds.), Methods in Immunology and Immunochemistry, Vol. II, Academic Press, New York, p. 328.Google Scholar
  32. Mannick, J. A., and Egdahl, R. N. (1962). Ann. Surg. 156: 356.PubMedCrossRefGoogle Scholar
  33. Miller, D. B., and Steiner, R. F. (1966). Biochemistry 5:2289.Google Scholar
  34. Mitchison, N. A. (1969). Immunology 16: 1.PubMedGoogle Scholar
  35. Mosier, D. E. (1967). Science 158: 1575.CrossRefGoogle Scholar
  36. Mosier, D. E., and Coppleson, L. W. (1968). Proc. Natl. Acad. Sci. 61: 542.PubMedCrossRefGoogle Scholar
  37. Mozes, E., Shearer, G. M., Sela, M., and Braun, W. (1971). In Beers, R. E., and Braun, W. (eds.), Biological Effects of Polynucleotides, Springer-Verlag, New York, p. 197. Pierce, C. W. (1969). J. Exptl. Med. 130:345.Google Scholar
  38. Plescia, O. J., Braun, W., and Palczuk, N. C. (1964). Proc. Natl. Acad. Sci. 52: 279.PubMedCrossRefGoogle Scholar
  39. Raidt, D. J., Mishell, R. I., and Dutton, R. W. (1968). J. Exptl. Med. 128: 681.CrossRefGoogle Scholar
  40. Raska, K., and Cohen, E. P. (1968). Nature (Lond.) 217: 5130.CrossRefGoogle Scholar
  41. Roelants, G. E., and Goodman, J. W. (1968). Biochemistry 7: 1432.Google Scholar
  42. Roelants, G. E., and Goodman, J. W. (1969). J. Exptl. Med. 130: 557.CrossRefGoogle Scholar
  43. Roelants, G. E., Goodman, J. W., and McDevitt, H. O. (1970). J. Immunol. 106: 1222.Google Scholar
  44. Roholt, O. A., Radzimski, G., and Pressman, D. (1965). J. Exptl. Med. 122: 785.CrossRefGoogle Scholar
  45. Sabbadini, E., and Sehon, A. H. (1967). Internat. Arch. Allergy 32: 55.CrossRefGoogle Scholar
  46. Schoenberg, M. D., Mumaw, W. R., Moore, R. D., and Weisberger, A. S. (1964). Science 143: 964.PubMedCrossRefGoogle Scholar
  47. Scolnick, E. M., Aaronson, S. A., Todaro, G. J., and Parks, W. P. (1971). Nature (Lond.) 229: 318.CrossRefGoogle Scholar
  48. Sela, M. (1969). Science 166: 1365.PubMedCrossRefGoogle Scholar
  49. Shortman, K., Diener, E., Russell, P., and Armstrong, W. D. (1970). J. Exptl. Med. 131:461. Stavnezer, J., and Huang, R. C. C. (1971). Nature (Lond.) 230: 172.Google Scholar
  50. Takanami, M., Okamoto, T., and Watanabe, I. (1961). J. Mol. Biol. 3: 476.CrossRefGoogle Scholar
  51. Talmage, D. W., Radovich, J., and Hemmingsen, H. (1970). Advan. Immunol. 12: 271.CrossRefGoogle Scholar
  52. Thor, D. E., and Dray, S. (1968a). J. Immunol 101: 51.PubMedGoogle Scholar
  53. Thor, D. E., and Dray, S. (1968b). J. Immunol. 101: 469.PubMedGoogle Scholar
  54. Thor, D. E., and Schlossman, S. (1969). Fed. Proc. 28: 629.Google Scholar
  55. Unanue, E. R. (1969). J. Immunol. 102: 893.PubMedGoogle Scholar
  56. Unanue, E. R., and Askonas, B. A. (1968). J. Exptl. Med. 127: 915.CrossRefGoogle Scholar
  57. Unanue, E. R., and Cerottini, J. C. (1970). J. Exptl. Med. 131: 711.CrossRefGoogle Scholar
  58. Zappacosta, F., and Nisonoff, A. (1968). J. Immunol. 100: 781PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Joel W. Goodman
    • 1
  1. 1.Department of MicrobiologyUniversity of California, San FranciscoSan FranciscoUSA

Personalised recommendations