Abstract
When a substance is repeatedly used it is reasonable to assume that in some way its use is reinforcing. It may be that it is necessary for life, it has a taste or smell worth seeking, or its use may lead to acceptance by peers. During periods of depression or anxiety, self-administration of an abused substance may relieve anxiety or depression.
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References
Arregui-Aguirre A, Claro-Izaguirre F, Goni-Garrido MJ, Zarate-Oleaga JA, Morgado-Bernal I (1987): Effects of acute nicotine and ethanol on medial prefrontal cortex self-stimulation in rats. Pharmacol Biochem Behav 27(1):15–20
Bain GT, Kornetsky C (1989): Ethanol oral self-administration and rewarding brain stimulation. Alcohol 6:499–503
Bain GT, Kornetsky C (1990): Opioids modification of central reward processes. In: Opioids, Bulimia and Alcohol Abuse and Alcoholism. Reid L, ed. New York: Springer-Verlag, pp 73–87
Bird M, Kornetsky C (1990): Dissociation of the attentional and motivational effects of pimozide on the threshold for rewarding brain stimulation. Neuropsychopharmacology 3:33–40
Broekkamp CL, Phillips AG, Cools AR (1979): Facilitation of self-stimulation behavior following intracerebal microinjections of opioids into the ventral tegmental area. Pharmacol Biochem Behav 11:289–295
Broekkamp CL, Pijnenburg AJ, Cools AR, Van Rossum JM (1975): The effect of microinjections of amphetamine into the neostriatum and the nucleus accumbens on self-stimulation behavior. Psychopharmacologia 42(2):179–183
Carlson RH, Lydic R (1976): The effects of ethanol upon threshold and response rate for self-stimulation. Psychopharmacology 50:61–64
Caudarella M, Campbell KA, Milgram NW (1982): Differential effects of diazepam (Valium) on brain stimulation reward sites. Pharmacol Biochem Behav 16:17–21
DeWitte P, Bada MF (1983): Self-stimulation and alcohol administered orally or intraperitoneally. Exp Neurol 8:675–682
Dworkin SM, Volkner C, Dworkin SI (1988): Toxic consequences of cocaine are augmented by non-contingent drug administration. Abstr Soc Neurosci 14:961
Engel J, Liljequist S (1976): The effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens. Psychopharmacology 49:253–257
Esposito R, Kornetsky C (1977): Morphine lowering of self-stimulation thresholds: lack of tolerance with long-term administration. Science 195:189–191
Esposito RU, Motola AH, Kornetsky C (1978): Cocaine: acute effects on reinforcement thresholds for self-stimulation behavior to the medial forebrain bundle. Pharmacol Biochem Behav 8:437–439
Fibiger HC, LePiane FG, Jakobovic A, Phillips AG (1987): The role of dopamine in intercranial self-stimulation of the ventral tegmental area. J Neurosci 7:3888–3896
Haertzen CA, Hooks NT (1969): Changes in personality and subjective experience associated with the chronic administration and withdrawal of opiates. J Nerv Ment Dis 148:606–614
Killam KF, Olds J, Sinclair J (1957): Further studies on the effects of centrally acting drugs on self-stimulation. J Pharmacol Exp Ther 119:157
Kornetsky C (1985): Brain-stimulation reward: a model for the neuronal bases for drug induced euphoria. In: Neuroscience Methods in Drug Abuse Research. National Institute on Drug Abuse Research Monograph, Supt. of Docs., U.S. Govt Printing Office, Washington DC, p 30
Kornetsky C, Bain GT, Unterwald EM, Lewis MJ (1988): Brain stimulation reward: effects of ethanol. Alcoholism: Clin Exp Res 12(5):609–616
Lai H, Makous WL, Horita A, Leung H (1979): Effects of ethanol on turnover and function of striatal dopamine. Psychopharmacology 61:1–9
Lewis MJ, Andrade JR, Mebane C, Phelps R (1984): Differential effects of ethanol and opiates on BSR threshold. Soc Neurosci Abstr 10:960
Lewis MJ, Phelps RW (1987): A multifunctional on-line brain stimulation system: investigation of alcohol and aging effects. In: Methods of Assessing the Reinforcing Properties of Abused Drugs. Bozarth MA, ed. New York: Springer-Verlag, p 463
Lorens SA, Sainati SM (1978): Naloxone blocks the excitatory effect of ethanol and chlordiazepoxide on lateral hypothalamic self-stimulation behavior. Life Sci 23:1359–1364
Moolten M, Kornetsky C (1990): Oral self-administration of ethanol and not experimenter administered ethanol facilitates rewarding electrical brain stimulation. Alcohol Clin Exp Res 7:3
Olds J, Killam KF, Bach-y-Rita P (1956): Self-stimulation of the brain used as a screening method for tranquilizing drugs. Science 124:265–266
Olds J, MiIner P (1954): Positive reinforcement produced by electrical stimulation of septal area and other regions of the rat brain. J Comp Physiol Psychol 47(6):419–427
Olds J, MiIner P (1954): Positive reinforcement produced by electrical stimulation of septal area and other regions of the rat brain. J Comp Physiol Psychol 47(6):419–427
Porrino LJ, Esposito RU, Seeger TF, Crane AM, Pert A, Sokoloff L (1984): Metabolic mapping of the brain during rewarding self-stimulation. Science 224:306–309
Rayport M (1954): Experience in the management of patients medically addicted to narcotics. JAMA 156:684–691
Reggiani A, Barbaccia ML, Spano PF, Trabucchi M (1980): Dopamine metabolism and receptor function after acute and chronic ethanol. J Neurochem 35:34–37
Routtenberg A (1981): Drugs of abuse and the endogenous reinforcement system: the resistance of intracranial self-stimulation behavior to the inebriating effects of ethanol. Ann NY Acad Sci 362:60–66
Schaefer GJ, Michael RP (1987): Ethanol and current thresholds for brain self-stimulation in the lateral hypothalamus of the rat. Alcohol 4:209–213
Seligman MEP (1972): Learned helplessness. In: Annual Review of Medicine. DeGraff AC, Creger WP, eds. California: Annual Reviews Inc, 23:407–412
Smith JE, Co C, Freeman ME, Lane JD (1982): Brain neurotransmitter turnover correlated with morphine-seeking behavior of rats. Pharmacol Biochem Behav 16:509–519
Laurent J (1972): Brain centers of reinforcement and the effects of alcohol. In: The Biology of Alcoholism, Volume 2: Physiology and Behavior. Kissen B, Begleiter H, eds. New York: Plenum Press, pp 85–106
Unterwald EM, Clark JA, Bain G, Kornetsky C (1984): The effects of ethanol on rewarding intracranial stimulation: rate and threshold measures. Abstr Soc Neurosci 10:572
Vrtunski P, Murray R, Wolin LR (1973): The effect of alcohol on intracranially reinforced response. Q J Stud Alcohol 34:718–725
Wayner MJ, Ono T, Nolley D (1975): Effects of ethyl alcohol on central neurons. Pharmacol Biochem Behav 3:499–506
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Kornetsky, C., Moolten, M., Bain, G. (1991). Ethanol and Rewarding Brain Stimulation. In: Meyer, R.E., Lewis, M.J., Koob, G.F., Paul, S.M. (eds) Neuropharmacology of Ethanol. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4757-1305-3_9
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DOI: https://doi.org/10.1007/978-1-4757-1305-3_9
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