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The Neuropharmacology of Ethanol Self-Administration

  • Chapter
Neuropharmacology of Ethanol

Abstract

The abuse liability of ethanol is thought to derive primarily from its anxiolytic and euphoric effects. Together, these properties are believed to underlie the acute reinforcing actions of ethanol that, in turn, sustain continued abuse and thereby ultimately may lead to the development of dependence. An increasing body of evidence suggests that the rewarding and intoxicating effects of ethanol are mediated by its actions on one or more specific neurotransmitter systems in the brain (Faber and Klee, 1977; Kulonen, 1983; Liljequist and Engel, 1979; Myers, 1978b; Tabakoff, 1977). However, although there is tentative evidence linking certain transmitters—notably the catecholamines, opioids, gamma-amino butyric acid and serotonin—or their receptors to aspects of the intoxicating actions of ethanol, no exclusive role for any transmitter in ethanol reward or dependence has yet been established.

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References

  • Ahlenius S, Engel J (1971): Effects of small doses of haloperidol on timing behavior. J Pharm Pharmacol 32:301–302

    Article  Google Scholar 

  • Altshuler HL, Phillips PE, Feinhandler DA (1980): Alterations of ethanol selfadministration by naltrexone. Life Sci 26:679–688

    Article  Google Scholar 

  • Amit S, Sutherland EA, Bill K, Ogren SO (1984): Zimelidine: a review of its effects on ethanol consumption. Neurosci Biobehav Rev 8:35–54

    Article  Google Scholar 

  • Amit Z, Brown ZW (1982): Actions of drugs of abuse on brain reward systems: a reconsideration with specific attention to alcohol. Pharmacol Biochem Behav 17:233–238

    Article  Google Scholar 

  • Amit Z, Levitan DE, Brown ZW, Sutherland EA (1977): Catecholaminergic involvement in alcohol’s rewarding properties: Implications for a treatment model for alcoholics. In: Advances in Experimental Medicine and Biology: Biological Aspects of Ethanol IIIa, vol. 85A. Gross MM, ed. New York: Plenum Press

    Google Scholar 

  • Amit Z, Stern MH (1971): A further investigation of alcohol preference in the laboratory rat induced by hypothalamic stimulation. Psychopharmacologia 21:317–327

    Article  Google Scholar 

  • Badawy AA-B, Evans M (1983): Opposite effects of chronic administration and subsequent withdrawal of drugs of dependence on the metabolism and disposition of endogenous and exogenous tryptophane in the rat. Alcohol 18:369–382

    Google Scholar 

  • Beaman CM, Hunter GA, Dunn LL, Reid LD (1984): Opioids, benzodiazepines and intake of ethanol. Alcohol 1:39–42

    Article  Google Scholar 

  • Blum K, Briggs AH, DeLallo L, Elston SFA, Ochoa R (1982): Whole brain methionine enkephalinase of ethanol avoiding and ethanol-preferring C57B1 mice. Experientia 38:1469–1470

    Article  Google Scholar 

  • Blum K, Briggs AH, Elston SFA, Hirst M, Hamilton MG, Verebey KA (1980): A common denominator theory of alcohol and opiate dependence: review of similarities and differences. In: Alcohol Tolerance and Dependence, Crabbe J, Rigter R, eds. New York: Elsevier/North Holland Biomedical Press

    Google Scholar 

  • Bozarth MA (1982): Opiate reward mechanisms mapped by intracranial selfadministration. In: Neurobiology of Opiate Reward, Smith JE, Lane JD, eds. New York: Raven Press

    Google Scholar 

  • Brown DR, Holtzman SG (1979): Suppression of deprivation-induced food and water intake in rats and mice by naloxone. Pharmacol Biochem Behav 11:567–573

    Article  Google Scholar 

  • Brown ZW, Amit Z (1977): The effects of selective catecholamine depletions by 6-hydroxydopamine on ethanol preference in rats. Neurosci Lett 5:333–336

    Article  Google Scholar 

  • Brown ZW, Gill K, Abitbol M, Amit Z (1982): Lack of effects of dopamine receptor blockade on voluntary ethanol consumption in rats. Behav Neural Biol 36(3):291–294

    Article  Google Scholar 

  • Bustos G, Roth RH (1976): Effect of acute ethanol treatment on transmitter synthesis and metabolism in central dopaminergic neurons. J Pharm Pharmacol 28:580–582

    Article  Google Scholar 

  • Carmichael FJ, Israel Y (1975): Effects of ethanol on neurotransmitter release by rat cortical slices. J Pharmacol Exp Ther 193:824–834

    Google Scholar 

  • Charness ME, Gordon AD, Diamond I (1984): Ethanol modulation of opiate receptors in cultured neuronal cells. Science 222:1246–1248

    Article  Google Scholar 

  • Cicero TJ (1979): A critique of animal analogues of alcoholism. In: Biochemistry and Pharmacology of Ethanol, vol. 2. Majchrowicz E, Noble EP, eds. New York: Plenum Press

    Google Scholar 

  • Collins MA (1988): Acetaldehyde and its condensation products as markers in alcoholism. In: Recent Developments in Alcoholism, vol. 6, Galanter M, ed. New York: Plenum Press

    Google Scholar 

  • Collins MA, Cheng BY (1988): Oxidative decarboxylation of salsinol-1-carbo xylic acid to 1,2-dehydrosalsinol: evidence for exclusive catalysis by particulate fractions in rat kidney. Arch Biochem Biophys 263:86–95

    Article  Google Scholar 

  • Collins MA, Kahn AJ (1982): Attraction to ethanol solutions in mice: induction by a tetrahydroisoquinoline of L-DOPA. Subs Alc Actions Misuse 3:299–302

    Google Scholar 

  • Cooper SJ (1980): Naloxone: effects on food and water consumption in the non-deprived and deprived rat. Psychopharmacology 71(1):1–6

    Article  Google Scholar 

  • Critcher EC, Lin CI, Patel J, Myers RD (1982): Attenuation of alcohol drinking in tetrahydroisoquinoline-treated rats by morphine and naltrexone. Pharmacol Biochem Behav 18:225–229

    Article  Google Scholar 

  • Daoust M, Chretien P, Moore N, Saligaut C, Lhuintre JP, Boismare F (1985): Isolation and striatal (3H) serotonin uptake: role in the voluntary intake of ethanol by rats. Pharmacol Biochem Behav 22:205–208

    Article  Google Scholar 

  • Dar MS, Wooles WR (1984): The effect of acute ethanol on dopamine metabolism in the striatum of mice. J Neural Transm 60:283–294

    Article  Google Scholar 

  • Davis VE, Walsh MJ (1970): Alcohol, amines, and alkaloids: a possible biochemical basis for alcohol addiction. Science 167:1005–1007

    Article  Google Scholar 

  • DeWit H, Wise RA (1977): Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine and phenoxybenzamine. Can J Psychol 31:195–203

    Article  Google Scholar 

  • DiChiara G, Corsini GU, Mereu GP, Tissari A, Gessa GL (1979): Self-inhibitory dopamine receptors: their role in the biochemical and behavioral effects of low doses of apomorphine. In: Advances in Biochemical Pharmacology. Roberts PJ, Woodruff GN, Iversen LL, eds. New York: Raven Press

    Google Scholar 

  • DiChiara G, Imperato A (1988): Preferential stimulation of dopamine release in mesolimbic systems: a common feature of drugs of abuse. In: Neurotransmitter Interactions in the Basal Ganglia. Sandler M, Feuerstein C, Scatton B, eds. New York: Raven Press

    Google Scholar 

  • Dole VP (1986): On the relevance of animal models to alcoholism in humans. Clin Exp Res 10:361–363

    Article  Google Scholar 

  • Duncan C, Dietrich RA (1980): A critical evaluation of tetrahydroisoquinolinesinduced ethanol preference in rats. Pharmacol Biochem Behav 13:265–281

    Article  Google Scholar 

  • Eriksson K (1969): Factors affecting voluntary alcohol consumption in the albino rat. Ann Zool Fenn 6:227–265

    Google Scholar 

  • Ettenberg A, Koob GF, Bloom FE (1981): Response artifact in the measurement of neuroleptic-induced anhedonia. Science 213:357–359

    Article  Google Scholar 

  • Ettenberg A, Pettit HO, Bloom FE, Koob GF (1982): Heroin and cocaine intravenous self-administration in rats: mediation by separate neural systems. Pharmacol Biochem Behav 13:729–731

    Google Scholar 

  • Faber DS, Klee MR (1977): Actions of ethanol on neuronal membrane properties and synaptic transmission. In: Alcohol and Opiates, Blum K, ed. New York: Academic Press

    Google Scholar 

  • Fadda F, Mosca E, Colombo G, Gessa GL (1989): Effects of spontaneous ingestion of ethanol on brain dopamine metabolism. Life Sci 44:281–287

    Article  Google Scholar 

  • Falk JL (1961): Production of polydipsia in normal rats by an intermittent food schedule. Science 133:195–196

    Article  Google Scholar 

  • Falk JL, Samson HH, Tang M (1973): Chronic ingestion techniques for the production of physical dependence on ethanol. In: Alcohol Intoxication and Withdrawal. Gross MM, ed. New York: Plenus Press

    Google Scholar 

  • Falk JL, Samson HH, Winger G (1972): Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat. Science 177:811–813

    Article  Google Scholar 

  • Ferko AP, Bobyock E (1979): Rates of ethanol disappearance from blood and hypothermia following acute and prolonged ethanol inhalation. Toxicol Appl Pharmacol 50:417–427

    Article  Google Scholar 

  • Fertel RH, Greenwald JE, Schwarz R, Wong L, Binanchine J (1980): Opiate receptor binding and analgesic effects of the tetrahydroisoquinolines salsinol and tetrahydropapaveroline. Res Commun Chem Pathol Pharmacol 27:3–16

    Google Scholar 

  • Fibiger HC (1978): Drugs and reinforcement mechanisms: a critical review of the catecholamine theory. Annu Rev Pharmacol Toxicol 18:37–56

    Article  Google Scholar 

  • Frenk H, Rogers GH (1979): The suppressant effects of naloxone on food and water intake in the rat. Behav Neural Biol 26:23–40

    Article  Google Scholar 

  • Frey H-H, Magnussen MP, Kaergaard H, Nielsen C (1970): The effect of ppchloroamphetamine on the consumption of ethanol by rats. Arch Int Pharmacodyn Ther 183:165–172

    Google Scholar 

  • Froehlich JC, Harts J, Lumeng L, Li T-K (1987): Naloxone attenuation of voluntary alcohol consumption. Alcohol Suppl 1:333–337

    Google Scholar 

  • Geller I (1973): Effects of para-chlorophenylalanine and 5-hydroxytryptophane on alcohol intake in rats. Pharmacol Biochem Behav 1:361–365

    Article  Google Scholar 

  • Genazzani AR, Nappi G, Facchinetti F, Mazella GL, Parrin D, Sinforiani E, Petraglia F, Savoldi F (1982): Central deficiency of β-endorphin in alcohol addicts. J Clin Endocrinol Metab 55:583–586

    Article  Google Scholar 

  • Gianoulakis C (1989): The effect of ethanol on the biosynthesis and regulation of opioid peptides. Experientia 45:428–435

    Article  Google Scholar 

  • Gill K, Amit Z (1987): Effects of serotonin uptake blockade on food, water and ethanol consumption in rats. Alcohol Clin Exp Res 11:444–449

    Article  Google Scholar 

  • Goeders NE, Smith JE (1983): Cortical dopaminergic involvement in cocaine reinforcement. Science 221:773–775

    Article  Google Scholar 

  • Gongwer MA, Murphy JM, McBride WJ, Lumeng L, Li TK (1989): Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high- and low-alcohol drinking lines of rats. Alcohol 6:317–320

    Article  Google Scholar 

  • Gothoni P, Ahtee L (1980): Chronic ethanol administration decreases 5-HT and increases 5-HIAA concentration in rat brain. Acta Pharmacol Toxicol 46:113–120

    Article  Google Scholar 

  • Grant KA, Samson HH (1985): Induction and maintenance of ethanol self-administration without food deprivation in the rat. Psychopharmacology 86: 475–479

    Article  Google Scholar 

  • Grupp LA, Perlanski E, Steward RB (1989): Angiotensin II-induced suppression of alcohol intake and its reversal by the angiotensin antagonist Sar-1 Thr-8 Angiotensin II. Pharmacol Biochem Behav 31:813–816

    Article  Google Scholar 

  • Ho AKS, Tsai CS, Chen RCA, Begleiter H, Kissin B (1974): Experimental studies on alcoholism I. Increase in alcohol preference by 5.6-dihydroxytryptamine and brain acetylcholine. Psychopharmacologia 40:101–107

    Article  Google Scholar 

  • Holman RB, Snape BM (1985a): Effects of ethanol on 5-hydroxytryptamine release from rat corpus striatum in vivo. Alcohol 2:249–253

    Article  Google Scholar 

  • Holman RB, Snape BM (1985b): Effects of ethanol in vitro and in vivo on the release of endogenous catecholamines from specific regions of the rat brain. J Neurochem 44:357–363

    Article  Google Scholar 

  • Holtzman SG (1979): Suppression of appetitive behavior in the rat by naloxone: lack of effect of prior morphine dependence. Life Sci 24:219–226

    Article  Google Scholar 

  • Hubner CB, Koob GF (1990): Bromocriptine produces decreases in cocaine self-administration in the rat. Neuropsychopharmacology 3:101–108

    Google Scholar 

  • Hunt WA, Majchrowicz E (1974): Rates and steady-state levels of brain serotonin in alcohol-dependent rats. Brain Res 72:181–184

    Article  Google Scholar 

  • Hunt WA, Majchrowicz E (1983): Studies of neurotransmitter interactions after acute and chronic ethanol administration. Pharmacol Biochem Behav 18:371–374

    Article  Google Scholar 

  • Hynes MA, Gallagher M, Yacos KV (1981): Systemic and intraventricular naloxone administration: effects on food and water intake. Behav Neural Biol 32:334–342

    Article  Google Scholar 

  • Imperato A, DiChiara G (1986): Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J Pharmacol Exp Ther 239:219–239

    Google Scholar 

  • Kalant H (1983): Animal models of alcohol and drug dependence: some questions, answers, and clinical implications. In: Etiologic Aspects of Alcohol and Drug Abuse. Gottheil E, Druley KA, Skoloda TE, Waxman HM, eds. Springfield, Ill.: Charles C. Thomas

    Google Scholar 

  • Kelly PH, Seviour PW, Iversen SD (1975): Amphetamine and apomorphine responses in the rat following 6-OHDA of the nucleus accumbens septi and corpus striatum. Brain Res 94:507–522

    Article  Google Scholar 

  • Khanna JM, Kalant H, Le AD, Mayer J, LeBlanc AE (1979): Effect of modification of brain serotonin (5-HT) on ethanol tolerance. Alcohol Clin Exp Res 3:353–358

    Article  Google Scholar 

  • Khanna JM, Le AD, Kalant H, LeBlanc AE (1980): Role of serotonin (5-HT) in tolerance to ethanol and barbiturates. In: Biological Effects of Alcohol. Begleiter H, ed. New York: Plenum Press

    Google Scholar 

  • Khatib SA, Murphy JM, McBride WJ (1988): Biochemical evidence for activation of specific monoamine pathways by ethanol. Alcohol 5:295–299

    Article  Google Scholar 

  • Kiianmaa K, Fuxe K, Jonson G, Ahtee L (1975): Evidence for involvement of central NA neurons in alcohol intake. Increased alcohol consumption after degeneration of the NA pathway in the cortex cerebri. Neurosci Lett 1:41–45

    Article  Google Scholar 

  • Kiianmaa K (1976): Alcohol intake in the rat after lowering brain 5-hydroxytryptamine content by electrolytic midbrain raphe lesions, 5,6-hydroxytryptamine or p-chlorophenylalanine. Med Biol 54:203–209

    Google Scholar 

  • Kiianmaa K, Andersson K, Fuxe K (1979): On the role of ascending dopamine systems in the control of voluntary ethanol intake and ethanol intoxication. Pharmacol Biochem Behav 10:603–608

    Article  Google Scholar 

  • Koob GF, Goeders N (1988): Neuroanatomical substrates of drug self-administration. In: Neuropharmacological Basis of Reward. Liebman JM, Cooper SJ, eds. Oxford: Oxford University Press

    Google Scholar 

  • Koob GF, Vaccarino FJ, Amalric M, Swerdlow NR (1987): Neural substrates for cocaine and opiate reinforcement. In: Cocaine: Clinical and Biobehavioral Aspects. Fischer S, Raskin A, Uhlenhuth EH, eds. New York: Oxford University Press

    Google Scholar 

  • Korpi ER, Sinclair JD, Malminen O (1987): Dopamine D2 receptor binding in striatal membranes of rats selected for differences in alcohol-related behaviors. Pharmacol Toxicol 61:94–97

    Article  Google Scholar 

  • Kulonen E (1983): Ethanol and GABA. Med Biol 61:147–167

    Google Scholar 

  • Lawrin MO, Naranjo CA, Sellers EM (1986): Identification of new drugs for modulating alcohol consumption. Psychopharmacol Bull 22:1020–1025

    Google Scholar 

  • Le AD, Khanna JM, LeBlanc AE (1981): Effect of modification of brain serotonin (5-HT), norepinephrine (NE) and dopamine (DA) on ethanol tolerance. Psychopharmacology 75:231–235

    Article  Google Scholar 

  • Lester D, Freed EX (1973): Criteria for an animal model of alcoholism. Pharmacol Biochem Behav 1:103–107

    Article  Google Scholar 

  • Li T-K, Lumeng L, McBride WJ, Waller MB, Murphy JM (1986): Studies on animal model of alcoholism. In: National Institute on Drug Abuse Research Monograph, Genetic and Biological Markers in Drug Abuse and Alcoholism. Braude E, Chao HM, eds. Rockville: NIDA

    Google Scholar 

  • Liljeqvist S (1978): Changes in the sensitivity of dopamine receptors in the nucleus accumbens and in the striatum induced by chronic ethanol administration. Acta Pharmacol Toxicol 43:19–28

    Article  Google Scholar 

  • Liljequist S, Engel J (1979): The effect of chronic ethanol administration on central neurotransmitter mechanisms. Med Biol 57:199–210

    Google Scholar 

  • Linseman MA (1986): Alcohol consumption in free-feeding rats—procedural and genetic factors. Soc Neurosci Abstr 12:279–279

    Google Scholar 

  • Linseman MA (1987): Alcohol consumption in free-feeding rats: procedural, genetic and pharmacokinetic factors. Psychopharmacology 92:254–261

    Article  Google Scholar 

  • Lucchi L, Lupini M, Govoni S, Covelli V, Spano PF, Trabucchi M (1983): Ethanol and dopaminergic systems. Pharmacol Biochem Behav 18(Suppl 1):379–382

    Article  Google Scholar 

  • Lumeng L, Li T-K(1986): The development of metabolic tolerance in the alcoholpreferring P-rats: comparison of forced and free-choice drinking of ethanol. Pharmacol Biochem Behav 25:1013–1020

    Article  Google Scholar 

  • Lumeng L, Waller MB, McBride WJ, Li T-K (1982): Different sensitivities to ethanol in alcohol-preferring and non-preferring rats. Pharmacol Biochem Behav 16:125–130

    Article  Google Scholar 

  • Lyness WH, Friedle NM, Moore KE (1979): Destruction of dopaminergic nerve terminals in the nucleus accumbens: Effect on d-amphetamine self-administration. Pharmacol Biochem Behav 11:556–563

    Article  Google Scholar 

  • Lyon M, Robbins TW (1975): The action of central nervous system stimulant drugs: a general theory concerning amphetamine effects. In: Current Developments in Psychopharmacology, vol. 2. Essman W, Valzelli L, eds. New York: Spectrum Publications

    Google Scholar 

  • Marfaing-Jallat P, Miceli D, LeMagnen J (1983): Decrease in ethanol consumption by naloxone in naive and dependent rats. Pharmacol Biochem Behav 18:5355–5395

    Article  Google Scholar 

  • McBride WJ, Murphy JM, Lumeng L, Li T-K (1988): Effects of Ro-15–4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and non-preferring (NP) lines of rats. Pharmacol Biochem Behav 30:1045–1050

    Article  Google Scholar 

  • Meisch RA (1977): Ethanol self-administration: infrahuman studies. In: Advances in Behavioral Pharmacology, vol. 1. Thompson T, Dews PB, eds. New York: Academic Press

    Google Scholar 

  • Meisch RA (1982): Animal studies of alcohol intake. J Psychiatr Res 141:113–120

    Article  Google Scholar 

  • Meisch RA (1984): Alcohol self-administration in experimental animals. In: Research Advances in Alcohol and Drug Problems. Smart RG, Glaser FB, Israel Y, Cappel H, Kalant H, Schmidt W, Sellers EM, eds. New York: Plenum Press

    Google Scholar 

  • Meisch RA, Henningfield JE (1977): Drinking of ethanol by rhesus monkeys: experimental strategies for establishing ethanol as a reinforcer. Adv Exp Med Biol 85:443–463

    Google Scholar 

  • Meisch RA, Thompson T (1971): Ethanol intake in the absence of concurrent food reinforcement. Psychopharmacologia 22:72–79

    Article  Google Scholar 

  • Mello NK (1973): A review of methods to induce alcohol addiction in animals. Pharmacol Biochem Behav 1:89–101

    Article  Google Scholar 

  • Mello NK (1976): Animal models for the study of alcohol addiction. Psychoneuroendocrinology 1:347–357

    Article  Google Scholar 

  • Morinan A (1987): Reduction in striatal 5-hydroxytryptamine turnover following chronic administration of ethanol to rats. Alcohol 22:56–60

    Google Scholar 

  • Murphy JM, McBride WJ, Lumeng L, Li T-K (1982): Regional brain levels of monoamines in alcohol-preferring and non-preferring lines of rats. Pharmacol Biochem Behav 16:145–149

    Article  Google Scholar 

  • Murphy JM, McBride WJ, Lumeng L, Li T-K (1987): Contents of monoamines in forebrain regions of alcohol-preferring (P) and non-preferring (NP) lines of rats. Pharmacol Biochem Behav 26:389–392

    Article  Google Scholar 

  • Murphy JM, Waller MB, Gatto GJ, McBride WJ, Lumeng L, Li T-K (1988): Effects of fluoxetine on the intragastric self-administration of ethanol in the alcohol-preferring P line of rats. Alcohol 5:283–286

    Article  Google Scholar 

  • Myers RD (1978a): Psychopharmacology of alcohol: a review. Pharmacol Toxicol 18:125–144

    Google Scholar 

  • Myers RD (1978b): Tetrahydroisoquinolines in the brain: the basis of an animal model of alcoholism. Clin Exp Res 2:145–154

    Article  Google Scholar 

  • Myers RD (1989): Isoquinolines, beta-carbolines and alcohol drinking: involvement of opioid and dopaminergic mechanisms. Experientia 45:436–443

    Article  Google Scholar 

  • Myers RD, Critcher EC (1982): Naloxone alters alcohol drinking induced in the rat by tetrahydropapaveroline (THP) infused ICV. Pharmacol Biochem Behav 16:827–836

    Article  Google Scholar 

  • Myers RD, Martin GE (1973): The role of cerebral serotonin in the ethanol preference of animals. Ann NY Acad Sci 215:135–144

    Article  Google Scholar 

  • Myers RD, Melchior CL (1975): Alcohol drinking in the rat after destruction of serotonergic and catecholaminergic neurons in the brain. Res Commun Chem Pathol Pharmacol 10:363–378

    Google Scholar 

  • Myers RD, Privette TH (1989): A neuroanatomical substrate for alcohol drinking: identification of tetrahydropapaveroline (THP)-reactive sites in rat brain. Brain Res Bull 22:899–911

    Article  Google Scholar 

  • Myers RD, Veale WL (1968): Alcohol preference in the rats: reduction following depletion of brain serotonin. Science 160:1469–1471

    Article  Google Scholar 

  • Naber D, Soble MG, Pickar D (1981): Ethanol increases opioid activity in plasma of normal volunteers. Pharmacopsychiatry 14:160–161

    Article  Google Scholar 

  • Nachman M, Lester D, LeMagnen J (1970): Alcohol aversion in the rat: behavioural assessment of noxious drug effects. Science 168:1244–1246

    Article  Google Scholar 

  • Opitz K (1969): Beobachtungen bei Alkohol trinkenden Ratten-Einfluss von Fenfluramin. Pharmacopsykiat Neurospychopharmakol 2:202–205

    Google Scholar 

  • Ostrowski NL, Foley TL, Lind MD, Reid LD (1980): Naloxone reduces fluid intake: effects of food and water deprivation. Pharmacol Biochem Behav 12:431–435

    Article  Google Scholar 

  • Parker LF, Radow BL (1976): Effects of parachlorophenylalanine on ethanol self-selection in the rat. Pharmacol Biochem Behav 4:535–540

    Article  Google Scholar 

  • Patel VA, Pohorecky LA (1989): Acute and chronic ethanol treatment on beta-endorphin and catecholamine levels. Alcohol 6:59–63

    Article  Google Scholar 

  • Pekkanen L, Rusi M (1979): The effects of niacin and riboflavin on voluntary ethanol intake and metabolism in rats. Pharmacol Biochem Behav 11:575–579

    Article  Google Scholar 

  • Pfeffer A, Seizinger BR, Herz A (1981): Chronic ethanol inhibition interferes with delta-, but not with mu-opiate receptors. Neuropharmacology 20:1229–1232

    Article  Google Scholar 

  • Pfeffer AO, Samson HH (1985): Oral ethanol reinforcement in the rat: effects of acute amphetamine. Alcohol 2:693–697

    Article  Google Scholar 

  • Pfeffer AO, Samson HH (1985): Oral ethanol reinforcements: interactive effects of amphetamine, pimozide and food restriction. Alcohol Drug Res 6:37–48

    Google Scholar 

  • Pfeffer AO, Samson HH (1986): Effect of pimozide on home cage ethanol drinking in the rat: dependence on drinking session length. Drug Alcohol Depend 17:47–55

    Article  Google Scholar 

  • Pfeffer AO, Samson HH (1988): Haloperidol and apomorphine effects on ethanol reinforcement in free-feeding rats. Pharmacol Biochem Behav 29:343–350

    Article  Google Scholar 

  • Pohorecky LA, Newman B, Sun J, Baile WH (1978): Acute and chronic ethanol ingestion and serotonin metabolism in the rat brain. J Pharmacol Exp Ther 224:424–432

    Google Scholar 

  • Pulvirenti L, Kastin AJ (1988): Naloxone, but not Tyr-NiIF-1, reduces volitional ethanol drinking in rats: correlation with degree of spontaneous preferences. Pharmacol Biochem Behav 31:129–129

    Article  Google Scholar 

  • Rassnick S, Pulvirenti L, Koob GF (1989): Effects of a novel dopamine agonist, Sandoz 205–152, on ethanol self-administration. Soc Neurosci Abstr 15:251

    Google Scholar 

  • Reid LD, Hunter GA (1984): Morphine and naloxone modulate intake of ethanol. Alcohol 1:33–37

    Article  Google Scholar 

  • Richter CP, Campbell KH (1940): Alcohol taste thresholds and concentrations of solution preferred by rats. Science 91:507–508

    Article  Google Scholar 

  • Robbins TW, Roberts TCS, Koob GF (1983): The effects of d-amphetamine and apomorphine upon operant behavior and schedule-induced licking in rats with 6-hydroxydopamine lesions of the nucleus accumbens. J Pharmacol Exp Ther 224:662–673

    Google Scholar 

  • Roberts DCS, Koob GF, Klonoff P, Fibiger HC (1980): Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens. Pharmacol Biochem Behav 12:781–787

    Article  Google Scholar 

  • Roberts SCS, Koob GF (1982): Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats. Pharmacol Biochem Behav 17:901–904

    Article  Google Scholar 

  • Rockman GE, Amit Z, Brown W, Bourque C, Ogren SO (1982): An investigation of the mechanisms of action of 5-hydroxytyptamine in the suppression of ethanol intake. Neuropharmacology 21:341–347

    Article  Google Scholar 

  • Rockman GE, Amit Z, Carr G, Brown ZW, Ogren SO (1979): Attenuation of ethanol by 5-hydroxytryptamine blockade in laboratory rats. I. Involvement of brain 5-hydroxytryptamine in the mediation of positive reinforcing properties of ethanol. Arch Int Pharmacodyn Ther 241:245–259

    Google Scholar 

  • Roehrs TA, Samson HH (1982): Relative responding on concurrent schedules: indexing ethanol’s reinforcing efficacy. Pharmacol Biochem Behav 16:393–396

    Article  Google Scholar 

  • Samson HH (1986): Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats. Alcohol Clin Exper Res 10:436–442

    Article  Google Scholar 

  • Samson HH (1987): Initiation of ethanol-maintained behavior: a comparison of animal models and their implication to human drinking. In: Neurobehavioral Pharmacology, vol. 6: Advances in Behavioral Pharmacology. Thompson T, Dews P, Barret J, eds. New Jersey: Erlbaum Associates

    Google Scholar 

  • Samson HH, Doyle TF (1985): Oral ethanol self-administration in the rat: effects of naloxone. Pharmacol Biochem Behav 22:91–99

    Article  Google Scholar 

  • Sandi C, Borell J, Guzaz C (1988): Naloxone decreases ethanol consumption within a free choice paradigm in rats. Pharmacol Biochem Behav 29:39–43

    Article  Google Scholar 

  • Sandler M, Carter SB, Hunter KR, Stem GM (1973): Tetrahydroisoquinoline alkaloids: in vivo metabolites of L-dopa in man. Nature 241:439–443

    Article  Google Scholar 

  • Sandler M, Glover V, Armando I, Clow A (1982): Pictet-Spengler condensation products, stress and alcoholism: some clinical overtones. Prog Clin Biol Res 90:215–226

    Google Scholar 

  • Sanger DL, McCarthy PS (1982): A comparison of the effects of opiate antagonists on operant and ingestive behavior. Pharmacol Biochem Behav 16:1013–1015

    Article  Google Scholar 

  • Schaefer GJ (1988): Opiate antagonists and rewarding brain stimulation. Neurosci Bio behav Rev 12:1–17

    Article  Google Scholar 

  • Schaefer GJ, Michael RP (1984): Drug interactions on spontaneous locomotor activity in rats: neuroleptics and amphetamine-induced hyperactivity. Neuropharmacology 23:909–914

    Article  Google Scholar 

  • Schultz R, Wuster M, Duka T, Herz A (1980): Acute and chronic ethanol treatment changes endorphin levels in brain and pituitary. Psychopharmacology 68:221–227

    Article  Google Scholar 

  • Seizinger BR, Bovermann K, Moysinger D, Hollt V, Herz A (1983): Differential effect of acute and chronic ethanol treatment on particular opioid peptide systems in discrete regions of the rat brain and pituitary. Pharmacol Biochem Behav 18:361–369

    Article  Google Scholar 

  • Signs SA, Yamamoto BK, Schechter MD (1987): In vivo electrochemical determination of extracellular dopamine in the caudate of freely moving rats after a low dose of ethanol. Neuropharmacology 26:1653–1656

    Article  Google Scholar 

  • Sinclair JD, Senter RJ (1967): Increased preference for ethanol in rats following alcohol deprivation. Psychon Sci 8:11–12

    Article  Google Scholar 

  • Stapleton JM, Ostrowski NL, Merriman VJ, Lind MD, Reid LD (1979): Naloxone reduces fluid consumption in deprived and nondeprived rats. Bull Psychon Soc 13:237–239

    Google Scholar 

  • Stein JM, Wayner MJ, Tilson HA (1977): The effect of parachlorophenylalanine on the intake of ethanol and saccharin solutions. Pharmacol Biochem Behav 6:117–122

    Article  Google Scholar 

  • Steward RB, Grupp LA (1984): A simplified procedure for producing ethanol self-administration in rats. Pharmacol Biochem Behav 21:255–258

    Article  Google Scholar 

  • Stewart RB, Perlanski E, Grupp LA (1988): Ethanol as a reinforcer for rats: factors of facilitation and constraint. Alcoholism Clin Exp Res 12:599 – 608

    Article  Google Scholar 

  • Tabakoff B (1977): Neurochemical aspects of ethanol dependence. In: Alcohol and Opiates. Blum K, ed. New York: Academic Press

    Google Scholar 

  • Tabakoff B, Boggan WO (1974): Effects of ethanol on serotonin metabolism in brain. J Neurochem 22:759–764

    Article  Google Scholar 

  • Tabakoff B, Hoffman PL (1983): Alcohol interaction with brain opiate receptors. Life Sci 32:197–204

    Article  Google Scholar 

  • Tabakoff B, Ritzmann RF, Boggan WO (1975): Inhibition of the transport of 5-hydroxyindoleacetic acid from brain by ethanol. J Neurochem 24:1043–1051

    Article  Google Scholar 

  • Ushijima I, Mizuki Y, Yamada M (1988): The mode of action of bromocriptine following pretreatment with reserpine and a-methyl-p-tyrosine in rats. Psychopharmacology 95:29–33

    Google Scholar 

  • Van de Kar LD, Wilkinson CW, Ganong WF (1981): Pharmacological evidence for a role of brain serotonin in the maintenance of plasma renin activity in unanaesthetized rats. J Pharmacol Exp Ther 219:85–90

    Google Scholar 

  • Veale WL (1973): Ethanol selection in the rat following forced acclimation. Pharmacol Biochem Behav 1:233–235

    Article  Google Scholar 

  • Veale WL, Myers RD (1970): Decrease in ethanol intake in rats following administration of p-chlorophenylalanine. Neuropharmacology 9:317–326

    Article  Google Scholar 

  • Volpicelli R, Davis MA, Olgin JE (1986): Naltrexone blocks the post-shock increase of ethanol consumption. Life Sci 38:841–847

    Article  Google Scholar 

  • Waller MB, Murphy JM, McBride WJ, Lumeng L, Li T-K (1986): Effect of low-dose ethanol on spontaneous motor activity in alcohol-preferring and nonpreferring rats. Pharmacol Biochem Behav 24:617–623

    Article  Google Scholar 

  • Wallgren H, Barry HIII (1970): Actions of Alcohol. Amsterdam: Elsevier Publishing Corporation

    Google Scholar 

  • Wayner MJ, Greenberg I (1972): Effects of hypothalamic stimulation, acclimation and periodic withdrawal on ethanol consumption. Physiol Behav 9:737–740

    Article  Google Scholar 

  • Wayner MJ, Greenberg I, Tartaglione R, Nolley D, Fraley S, Cott A (1972): A new factor affecting the consumption of ethyl alcohol and other sapid fluids. Physiol Behav 8:345–362

    Article  Google Scholar 

  • Weiss F, Mitchiner M, Bloom FE, Koob GF (1990): Free-choice responding for ethanol versus water in alcohol-preferring (P) and unselected Wistar rats is differentially altered by naloxone, bromocriptine and methysergide. Psychopharmacology 101:178–186

    Article  Google Scholar 

  • Wise RA (1973): Voluntary ethanol intake in rats following exposure to ethanol on various schedules. Psychopharmacology 29:203–210

    Article  Google Scholar 

  • Wise RA (1978): Catecholamine theories of reward: a critical review. Brain Res 152:162–175

    Article  Google Scholar 

  • Wise RA (1980): Action of drugs of abuse on brain reward systems. Pharmacol Biochem Behav 13(Suppl 1):213–232

    Article  Google Scholar 

  • Wise RA (1982): Neuroleptics and operant behavior: the anhedonia hypothesis. Behav Brain Sci 5:39–88

    Article  Google Scholar 

  • Wise RA (1984): Neural mechanisms of the reinforcing actions of cocaine. In: NIDA Research Monograph Cocaine: Pharmacology, Effects, and Treatment of Abuse. Grabowski, ed. Rockville: NIDA

    Google Scholar 

  • Wise RA, Bozarth MA (1982): Action of drugs of abuse on brain reward systems: an update with specific attention to opiates. Pharmacol Biochem Behav 17:239–243

    Article  Google Scholar 

  • Yokel RA, Wise RA (1975): Increased lever pressing for amphetamine after pimozide in rats: Implications for a dopamine theory of reward. Science 187:547–549

    Article  Google Scholar 

  • Yokel RA, Wise RA (1976): Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats. Psychopharmacology 48:311–318

    Article  Google Scholar 

  • York JL (1978): A comparison of the discriminative stimulus properties of ethanol, barbital, and phenobarbital in rats. Psychopharmacology 60:19–23

    Article  Google Scholar 

  • Yoshimoto K, Komura S (1987): Re-examination of the relationship between alcohol preference and brain monoamines in inbred strains of mice including senescence-accelerated mice. Pharmacol Biochem Behav 27:317–322

    Article  Google Scholar 

  • Yoshimoto K, Komura S, Mizohata K (1985): Alcohol preference and brain monoamines in five inbred strains of mice. IRCS Med Sci 13:1192–1193

    Google Scholar 

  • Zabik JE, Blinkerd K, Roache JD (1985): Serotonin and ethanol aversion in the rat. In: Research Advances in New Psychopharmacological Treatments of Alcoholism. Naranjo CA, Sellers EM, eds. New York: Excerpta Medica

    Google Scholar 

  • Zimmerman H, Ganong WF (1980): Pharmacological evidence that stimulation of central serotonergic pathways increases renin secretion. Neuroendocrinology 30:101–107

    Article  Google Scholar 

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Authors
  1. F. Weiss
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  2. G. F. Koob
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, School of Medicine, University of Connecticut Health Center, Farmington, CT, 06032, USA

    Roger E. Meyer M.D.

  2. Department of Psychology, Howard University and O.S.A., N.I.A.A.A., Rockville, MD, 20857, USA

    Michael J. Lewis Ph.D.

  3. Research Institute of the Scripps Clinic, La Jolla, CA, 92037, USA

    George F. Koob Ph.D.

  4. N.I.H., N.I.M.H., Bethesda, MD, 20892, USA

    Steven M. Paul M.D.

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© 1991 Springer Science+Business Media New York

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Weiss, F., Koob, G.F. (1991). The Neuropharmacology of Ethanol Self-Administration. In: Meyer, R.E., Lewis, M.J., Koob, G.F., Paul, S.M. (eds) Neuropharmacology of Ethanol. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4757-1305-3_7

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  • DOI: https://doi.org/10.1007/978-1-4757-1305-3_7

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4757-1307-7

  • Online ISBN: 978-1-4757-1305-3

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