Cell Heterogeneity and Complexity of Breast Epithelial Surface Antigens Expression and Moab Therapy

  • Jerry A. Peterson
  • Edward Blank
  • Cindy Zoellner
  • Sean Enloe
  • Garrett Walkup
  • Roberto L. Ceriani

Abstract

The advent of monoclonal antibodies has opened a new area of breast cancer therapy, and because of unique aspects compared to conventional therapy new approaches have to be defined, and new problems addressed. Monoclonal antibodies have to be selected specifically for therapy, ideal characteristics have to be defined, conjugates must be selected, conjugation methods must be evaluated, and appropriate target antigens have to be identified. One aspect of the latter that must be taken into consideration is the complexity and cell heterogeneity in expression of most antigens that have an appropriate tissue or tumor cell specificity for therapy. This paper will address the question of antigenic heterogeneity in approaching the use of monoclonal antibodies for therapy of breast cancer.

Keywords

Nude Mouse Breast Tumor Breast Epithelial Cell Human Mammary Epithelial Cell Breast Carcinoma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Jerry A. Peterson
    • 1
  • Edward Blank
    • 1
  • Cindy Zoellner
    • 1
  • Sean Enloe
    • 1
  • Garrett Walkup
    • 1
  • Roberto L. Ceriani
    • 1
  1. 1.John Muir Cancer and Aging Research InstituteWalnut CreekUSA

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