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Breast Cancer Immunodiagnosis and Immunotherapy pp 81–93Cite as

Epithelial Mucin Antibodies and Their Epitopes: Core Protein Epitopes of a Polymorphic Epithelial Mucin (PEM)

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Abstract

Largely because of their complexity, the detailed structure of the mucins has been difficult to analyze. This group of compounds is categorized mainly by the fact that they contain a high level of carbohydrate which is attached in O-linkage to serine and/or threonine via the linkage sugar N-acetylgalactosamine. The mucous secretions produced by some epithelial cells, particularly those lining the gastro-intestinal tract and the lungs, contain mucins along with other products and these components have been studied for some time at the biochemical level. However, other glandular epithelial cells, such as the salivary gland, breast, ovary, endometrium, and sweat glands, also produce mucins, and some of these simpler mucins have recently received much attention. This is because many antibodies selected for epithelial or tumor specificity have been found to react with high molecular weight glycoproteins which are produced by simple epithelial cells and have the properties of mucins.1–9

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Authors and Affiliations

  1. Imperial Cancer Research Fund, Lincoln’s Inn Fields, P O Box 123, WC2A 3PX, London, UK

    Joyce Taylor-Papadimitriou, Joy Burchell, Sandra Gendler, Martina Boshell & Trevor Duhig

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  1. Joyce Taylor-Papadimitriou
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  2. Joy Burchell
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  4. Martina Boshell
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  5. Trevor Duhig
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  1. John Muir Cancer and Aging Research Institute, Walnut Creek, California, USA

    Roberto L. Ceriani

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© 1989 Springer Science+Business Media New York

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Taylor-Papadimitriou, J., Burchell, J., Gendler, S., Boshell, M., Duhig, T. (1989). Epithelial Mucin Antibodies and Their Epitopes: Core Protein Epitopes of a Polymorphic Epithelial Mucin (PEM). In: Ceriani, R.L. (eds) Breast Cancer Immunodiagnosis and Immunotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1296-4_8

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  • DOI: https://doi.org/10.1007/978-1-4757-1296-4_8

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