An Assay for Cryptic Tumor Antigens in Sera of Women with Breast Cancer
The utility of circul ating mucins as breast cancer markers was first proposed by Ceriani, et al. (1) and was rapidly confirmed and expanded by many other laboratories, including those of Chu, Taylor-Papadimitriou, Hilgers and Kufe (2–5). The antibodies used in mucin assays measure epitopes expressed on or cross-reactive with the human milk-fat globule membrane (HMFG) antigens. Assays using antibodies developed in many of the above mentioned laboratories are now commercially available, and have been used with some success in moni tori ng breast cancer patients.
KeywordsBreast Cancer Sialic Acid Benign Breast Disease Roswell Park Memorial Institute Neuraminidase Treatment
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