Abstract
One of the greatest challenges in breast cancer research today involves the identification and isolation of breast cancer antigens. The study of antigens associated with these malignancies has been ongoing for years.
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References
H. Koprowski, Z. Steplewski, and K. Mitchell, Colorectal carcinoma antigens detected by hybridoma antibodies, Somatic Cell Genet 5:957–972 (1979).
R.C. Bast Jr., M. Ferney, L.M. Nadler, R.B. Colvin, and R.C. Khapp, Reactivity of monoclonal antibody with human ovarian carcinoma, J. Clin. Invest 68:1331–1337 (1981).
T.L. Klug, M.A. Sattler, D. Colcher, and J. Schlom, Monoclonal antibody immunoradiometric assay for an antigenic determinant (CA72) on a novel pancarcinoma antigen (TAG-72), Int. J. Cancer 38:661–669 (1986).
A.C. Morgan, D.R. Galloway, and R.A. Reisfeld, Production and characterization of monoclonal antibody to a melanoma specific glycoprotein, Hybridoma 1:27–36 (1981).
S. DelVechio, J.C. Reynolds, R.C. Blasberg, R.D. Neumann, J. A. Carrasquilla, I. Hellstrom, and S.M. Larson, Measurement of local Mr 97,000 and 250,000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography, Cancer Res 48:5475–5481 (1988).
D. Colcher, J. Esteban, J.A. Carrasquillo, P. Sugarbaker, J.C. Reynolds, G. Bryant, S.M. Larson, and J. Schlom, Complementation of intracavitary and intravenous administration of a monoclonal antibody (B72.3) in patients with carcinoma, Cancer Res 57:4218–4224 (1987).
E.W. Martin, CM. Mojzisik, G.H. Hinkle, J. Sampsei, M.A. Siddiqi, S.E. Tuttle, B. Sickle-Santanello, D. Colcher, M.O. Thurston, J.G. Bell, W.B. Farrar, and J. Schlom, Radioimmuroguided surgery: a new approach to the intraoperative detection of tumor using monoclonal antibody B72.3, Am. J. Surg. In press (1988).
B.J. Sickle-Santanello, P.J. O’Dwyer, C. Mojzisik, S.E. Tuttle, G.H. Hinkle, A. Sardi, J.P. Minton, E. W. Martin, Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors, Dis. Colon Rectum 30:761–764 (1987).
D. Colcher, P. Horan Hand, M. Nuti, and J. Schlom, A spectrum of monoclonal antibodies reactive with human mammary tumor cells, Proc. Natl. Acad. Sci. USA 78:3199–3203 (1981).
M. Nuti, Y.A. Teramoto, R. Mariani-Costantini, P. Horan Hand, D. Colcher, and J. Schlom, A monoclonal antibody (B72.3) defines patterns of distribution of a novel tumor associated antigen in human mammary carcinoma cell populations, Int. J. Cancer 29:529–545 (1982).
J. Hilkens, F. Buijs, J. Hilgers, P. Hageman, J. Calafar, A. Sonnenberg, and M. van der Valk, Monoclonal antibodies against human milk-fat globule membrane detecting differentiation antigens of the gland and its tumors, Int. J. Cancer 34:197–206 (1984).
I.O. Ellis, C.P. Hinton, J. MacNay, C.W. Elston, A. Rabbins, A.A. Owainati, R.W. Blarney, R.W. Baldwin, and B. Ferry, Immunocytochemical staining of breast carcinoma with the monoclonal antibody NCRC 11: a new prognostic indicator, Br. Med. J 290:881–883 (1985).
J. Burchell, H. Durbin, and J. Taylor-Papdimitriou, Complexity of expression of antigenic determinant recognized by monoclonal antibodies HMPG-1 and HMPG-2, in normal and malignant human mammary epithelial cells, J. Immunol 131:508–513 (1983).
M.S. Lan, R.C. Bast, M.I. Colnaghi, R.C. Knapp, D. Colcher, J. Schlom, and R.S. Metzghar, Co-expression of human cancer-associated epitopes on mucin molecules. Int. J. Cancer 39:68–72 (1987).
P. Horan Hand, D. Colcher, D. Salomon, J. Ridge, P. Noguchi, and J. Schlom, Influence of spatial configuration of carcinoma cell populations in the expression of tumor associated glycoprotein, Cancer Res 45:833–840 (1985).
P. Horan Hand, M. Nuti, D. Colcher, J. Schlom, Definition of antigenic heterogeniety and modulation among human mammary carcinoma cell populations using monoclonal antibodies to tumor-associated antigens, Cancer Res 43:728–735 (1985).
D.F. Hayes, H. Sekine, T. Ohno, M. Abe, K. Keefe, and D.W. Rufe, Use of a murine monoclonal antibody for detection of circulating plasma DF3 antigen levels in breast cancer patients, J. Clin. Invest 75:1671–1678 (1985).
J. Hilkens, V. Kroezen, J.M.G. Bonfrer, M. DeJong-Bakker, and P.F. Bruning, MAM-6 antigen, a new serum marker for breast cancer monitoring, Cancer Res 46:2582–2587 (1986).
P.S. Linsley, V. Ochs, S. Laska, D. Horn, D.B. Ring, A.E. Frankel and J. Brown, Elevated levels of a high molecular weight antigen detected by antibody WI in sera from breast cancer patients, Cancer Res 46:5444–5450 (1986).
J. Burchell, D. Wang, and J. Taylor-Papdimitriou, Detection of the tumor-associated antigens recognized by the monoclonal antibodies HMFG-1 and 2 in serum from patients with breast cancer. Int. J. Cancer 34:763–768 (1984).
A.J. Strelkauskas, C. Lofton, and P.H. Aldenderfer, Human monoclonal antibody: 2. Simultaneous expression of IgS and IgM with similar binding specificities by a human hybrid clone, Hybridoma 6:479–487 (1987).
A.J. Strelkauskas, “Human Hybridomas”, Marcel Dekker, New York (1987).
A.J. Strelkauskas, and C.L. Taylor, Human monoclonal antibody. Construction of stable clones reactive with human breast cancer, Cancer Immunol. Immunother 23:31–40 (1986).
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Strelkauskas, A.J., Aldenderfer, P.H. (1989). The Use of Human Monoclonal Antibodies to Identify and Isolate Breast Tumor Associated Antigens. In: Ceriani, R.L. (eds) Breast Cancer Immunodiagnosis and Immunotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1296-4_4
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DOI: https://doi.org/10.1007/978-1-4757-1296-4_4
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