Extracellular Keratins: An Update
Four years ago we announced the production of a series of monoclonal antibodies which react with the major epithelial keratins of MCF7 and other breast cancer cell lines (1). One of the antibodies, UCD/PR 10.11, has proven to be an excellent reagent, when used in the immunoperoxidase technique, for the diagnosis of epithelial malignancies (2). UCD/PR 10.11 reacts with CK 8 and 18. It has a superb signal-to-noise ratio in staining almost all simple epithelia and is thought by some to be one of the best diagnostic monoclonal anti-keratin available for immunopathology (3). It is now commercially available through Triton Biosciences, Inc.
KeywordsBreast Cancer Bladder Cancer MCF7 Cell Transitional Cell Carcinoma Benign Breast Disease
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