The Oncogenic Potential of Membrane Receptor Proteins Encoded by Members of the Human erbB Proto-Oncogene Family
Investigations of genetic alterations associated with neoplasia have identified a limited set of cellular genes, termed proto-oncogenes, which are highly conserved in vertebrate evolution. Acute transforming retroviruses have substituted viral genes essential for replication with these discrete segments of host genetic information. When incorporated within the retroviral genome, such transduced sequences acquire the ability to induce neoplastic transformation (1,2). Analysis of products of viral oncogenes has revealed important insights concerning the physiological roles of their normal cellular counterparts, designated protooncogenes. In particular, recent evidence has established a direct link between oncogene products and growth factor receptors. The v-erbB. oncogene was identified as a structurally altered version of the epidermal growth factor (EGF) receptor (3), while v-fms shares homology with colony stimulating factor-1 (CSF-1) receptor (4).
KeywordsEpidermal Growth Factor Receptor Epidermal Growth Factor Mammary Tumor Epidermal Growth Factor Receptor Gene Epidermal Growth Factor Receptor Protein
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