The Calmodulin-Dependent Phosphorylation of Cardiac Myosin

  • Franz Hofmann
  • Manfred Zimmer
Part of the Advances in Myocardiology book series (ADMY)


Cardiac myosin light chains are phosphorylated in vivo and in vitro. The enzyme, myosin light-chain kinase, has been purified and found to be very specific for cardiac myosin light chains. Experiments with skinned cardiac fibers suggest that phosphorylation of myosin light chain-2 decreases ATP consumption, presumably by lowering the cross-bridge cycle. These results are discussed in this chapter.


Light Chain Myosin Light Chain Myosin Light Chain Kinase Cardiac Enzyme Regulatory Light Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Franz Hofmann
    • 1
  • Manfred Zimmer
    • 1
  1. 1.Pharmakologisches InstitutUniversität HeidelbergHeidelbergFederal Republic of Germany

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