Disturbances of the Heart Structure and Function in Chronic Hemolytic Anemia, Their Compensation with Increased Coronary Flow, and Their Prevention with Ionol, an Inhibitor of Lipid Peroxidation

  • F. Z. Meerson
  • M. E. Evsevieva
Part of the Advances in Myocardiology book series (ADMY)

Abstract

The structure and function of heart muscle were studied in rats with chronic hemolytic anemia induced by phenylhydrazine. Contractural lesions, myocytolysis, fatty dystrophy, and small-focal necrosis were found in the myocardium along with hypertrophy. The disturbances were accompanied by a compensatory increase in the coronary flow by 2.5-fold during myocardial contractions. When the coronary flow of isolated hearts was experimentally decreased to the control level, a great depression of the contractile function developed. Administration of the antioxidant ionol, an inhibitor of lipid peroxidation, simultaneously with phenylhydrazine did not prevent the development of the hemolytic anemia, but decreased by 2 times the degree of hypertrophy and the amount of the lesion foci in the heart muscle. It also significantly inhibited the compensatory increase of coronary flow and completely eliminated depression of the heart contractile function during the normalization of coronary flow. The data allow a suggestion that hemolytic anemia is accompanied by activated lipid peroxidation, this process playing a role in the myocardial damage of anemia. Antioxidants can prevent such damage.

Keywords

Hemolytic Anemia Coronary Flow Contractile Function Myocardial Damage Compensatory Increase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • F. Z. Meerson
    • 1
  • M. E. Evsevieva
    • 1
  1. 1.Laboratory of Heart PathophysiologyInstitute of General Pathology and Pathological Physiology of the USSR AMSMoscowUSSR

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