Abstract
The pathways for the metabolism of molecular oxygen involve one electron-transfer reaction with the subsequent production of reduced-oxygen intermediates. These reduced-oxygen intermediates include the superoxide anion (·O -2 ), hydrogen peroxide (H2O2), and the hydroxyl radical (·OH), which are highly reactive, short-lived species. Normally, intracellular enzyme systems that include superoxide dismutase, catalase, and glutathione peroxidase are responsible for “scavenging” these products of oxygen metabolism. However, in many pathological states such as inflammation, ischemia, and reperfusion, there is an increased production of these reduced-oxygen intermediates, which are capable of extensive tissue damage. It is the purpose of this symposium to examine, in depth, the role of oxygen free radical systems as mediators of myocardial dysfunction and expand our knowledge of myocardial ischemia, ischemia—reperfusion injury, and the inflammatory response of the myocardium.
Keywords
- Chronic Granulomatous Disease
- Rheumatic Fever
- Myocardial Dysfunction
- Acute Rheumatic Fever
- Nervous System Disorder
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Fridovich, I. 1978. The biology of oxygen radicals. Science 201:875–888.
Pryor, W. A. 1976. The role of free radical reactions in biological systems. In: W. Pryor (ed.), Free Radicals in Biology. pp. 1–49. Academic Press, New York.
Thomas, M. J., Mehl, K. S., and Pryor, W. A. 1978. The role of superoxide anion in the xanthine-oxidase induced autoxidation of linoleic acid. Biochem. Biophys. Res. Commun. 83:927–932.
Babior, B. M. 1978. Oxygen-dependent microbial killing by phagocytes. Parts I and II. N. Engl. J. Med. 298:659–668 and 732–725.
Klebanoff, J. J. 1980. Oxygen metabolism and the toxic properties of phagocytes. Ann. Intern. Med. 93:480–489.
Haber, F., and Weiss, J. 1934. The catalytic decomposition of hydrogen peroxide by ion salts. Proc. R. Soc. 147:332–351.
Benon, H., Bielski, J., and Gebicki, J. M. 1977. Application of radiation chemistry to biology. In: W. Pryor (ed.), Free Radicals in Biology. Vol. 3, pp. 1–51. Academic Press, New York.
Demopoulos, H. G., Glamm, E. S., Seligman, M. L., Mitamura, J. A., and Ransohoff, J. 1979. Membrane perturbations in central nervous system injury: Theoretical basis for free radical damage. In: A. J. Popp, R. S. Bourke, L. R. Nelson, and H. K. Kimelberg (eds.), Neural Trauma. pp. 63–78. Raven Press, New York.
Demopoulos, H. B., Flamm, E. S., Pietronigro, D. D., and Seligman, M. L. 1980. The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiol. Scand. Suppl. 492:91–119.
Kontos, H. A., Wei, E. P., Dietrich, W. D., Navari, R. M., Povlishock, J. T., Ghatak, N. R., Ellis, E. F., Patterson, J. L. Mechanism of cerebral arteriolar abnormalities after acute hypertension. Am. J. Physiol. 240:H511–H527.
Wei, E. P., Kontos, H. A., Dietrich, W. D., Povlishock, J. T., and Ellis, E. F. 1981. Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities. Circ. Res. 48:95–103.
Dorfman, L. M., and Adams, G. E. 1973. Reactivity of hydroxyl free radicals in aqueous solutions. NSRDS NL35, No 46, United States Department of Commerce, National Bureau of Standards.
Kuehl, F. A., Humes, J. L., Ham, E. A., Egan, R. W., Dougherty, H. W. 1980. Inflammation: The role of peroxidase-derived products. Adv. Prostaglandin Thromb. Res. 6:77–86.
McCord, J. M. 1974 Free radicals and inflammation: Protection of synovial fluid by superoxide dismutase. Science 185:529–531.
Johnson, R. B., Keele, B. B., Misra, H. P., Lehmeyer, J. P., Webb, L. S., Baehner, R. L., Rajagopalan, K. V. 1975. The role of superoxide anion generation in phagocytic bacterial activity: Studies with normal and chronic granulomatous disease leukocytes. J. Clin. Invest. 55:1357–1372.
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Hess, M.L., Manson, N.H. (1985). The Oxygen Free Radical System and Myocardial Dysfunction. In: Harris, P., Poole-Wilson, P.A. (eds) Advances in Myocardiology. Advances in Myocardiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1287-2_13
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DOI: https://doi.org/10.1007/978-1-4757-1287-2_13
Publisher Name: Springer, Boston, MA
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