Abstract
The mosquito is an ideal laboratory model for the study of innate cellular defense mechanisms among the Metozoa. Although there may be nonspecific protective humoral factors present in the hemolymph of mosquitoes, there is presumably no specific humoral or antibody system as part of their arsenal of internal defense. In addition, both man and mosquitoes are susceptible to infection by parasites of the genus Plasmodium. In both mammals and mosquitoes, the malaria sporozoite must migrate through the circulation to reach a target organ (liver or salivary gland), and is therefore potentially susceptible to the cellular defense mechanisms of both hosts. This fortunate circumstance affords an opportunity to study the response of a purely cellular internal defense mechanism to the same stage of the same parasite which successfully evades the defense mechanisms of both mammals and mosquitoes.
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References
Amouriq, L. (1960). Formules hemocytaires de la larve, de la nymphe et de l’adulte de Culex hortensis (Dipt. Culicidae). Bull. Soc. Entom. France, 65, 135–139.
Andreadis, T. G. and Hall, D. W. (1976). Neoaplectana carpocapsae: Encapsulation in Aedes aegypti and changes in host hemocytes and hemolymph proteins. Exp. Parasitol., 39, 252–261.
Arnold, J. W. (1974). The hemocytes of insects. In: “The Physiology of Insecta,” (M. Rockstein, ed.), second edition, volume 5, pp. 201–254. Academic Press, New York.
Bhat, U. K. M. and Singh, K. R. P. (1975). The haemocytes of the mosquito Aedes albopictus and their comparison with larval cells cultured in vitro. Experientia, 31, 1331–1332.
Bronskill, J. F. (1962). Encapsulation of rhabditoid nematodes in mosquitoes. Can. J. Zool., 40, 1269–1275.
Chao, J. and Ball, G. H. (1956). Quantitative microinjection of mosqu itoes. Science, 123, 228–229.
Foley, D. A. and Cheng, T. C. (1977). Degranulation and other changes of molluscan granulocytes associated with phagocyt o s is. J. Invertebr. Patho l., 29, 321–325.
Huff, C. G. (1934). Comparative studies on susceptible and insu sc ept ible Culex pipiens in relation to inf ections with Plasmodium cathemerium and P. relictum. Am. J. Hyg., 19, 123–147.
Jones, J. C. (1954). The heart and associated tissues of Anopheles quadrimaculatus Say (Diptera:Culicidae). J. Morph., 94, 71–125.
Jones, J. C. (1962). Current concepts concerning insect hemocytes. Am. Zool., 2, 209–246.
Jones, J. C. (1970). Hemocytopoiesis in insects. In: “Regulat ion of Hematopoies is,” (A. S. Gordon, ed.), volume I, pp. 7–65. Appleton-Century-Crofts, New York.
Mack, S., Foley, D. A., and Vanderberg, J. P. (1978). Hemolymph volume of Anopheles stephensi. (manuscript in preparat ion).
Mack, S., Vanderberg, J. P., and Nawrot, R. (1978). Column separation of Plasmodium berghei sporozoites. J. Parasitol. (in press).
Oelerich, S. (1967). Vergleichende Untersuchungen uber das Auftreten von Malaria-Sporozoiten in den Speicheldrusen und in den ubrigen Organen der Mucke. Z. Tropenmed. Parasit., 18, 285–303.
Pringle, G. (1965). A count of the sporozoites in an oocyst of Plasmodium falciparum. Trans. R. Soc. Trop. Med. Hyg., 59, 289–290.
Shute, P. G. and Maryon, M. E. (1966). “Laboratory Technique for the Study of Malaria,” second edition, 112 pp. J. and A. Churchill, Ltd., London.
Strome, C. P. A. and Beaudoin, R. L. (1974). The surface of the malaria parasite 1. Scanning electron microscopy of the oocyst. Expt. Parasztol., 36, 131–142.
Vanderberg, J. P. (1977). Plasmodium berghei: Quantitation of sporozoites injected by mosquitoes feeding on a rodent host. Expt. Parasitol., 42, 169–181.
Weathersby, A. B. and McCall, J. W. (1968). The development of Plasmodium gallinaceum Brumpt in the hemocoels of refractory Culex pipiens pipiens Linn. and susceptible Aedes aegypti (Linn.). J. Parasitol., 54, 1017–1022.
Weiss, M. M. and Vanderberg, J. P. (1976). Studies on Plasmodium ookinetes. 1. Isolation and concentration from mosquito midguts. J. Protozool., 23, 547–551.
Whitcomb, R. F., Shapiro, M., and Granados, R. R. (1974). Insect defense mechanisms against microorganisms and parasitoids. In: “The Physiology of Insecta,” (M. Rockstein, ed.), second edition, volume 5, pp. 447–536. Academic Press, New York.
Yoeli, M. (1973). Plasmodium berghei: Mechanisms and sites of resistance to sporogonic development in dif f erent mosquitoes. Expt. Parasitol., 34, 448–458.
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Foley, D.A. (1978). Innate Cellular Defense by Mosquito Hemocytes. In: Bulla, L.A., Cheng, T.C. (eds) Invertebrate Models for Biomedical Research. Comparative Pathobiology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1278-0_8
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DOI: https://doi.org/10.1007/978-1-4757-1278-0_8
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