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A Study of Granuloma Formation by Molluscan Cells

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Invertebrate Models for Biomedical Research

Part of the book series: Comparative Pathobiology ((CPATH,volume 4))

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Abstract

The development, nature, and functional significance of infectious granulomatoses in mammals, particularly humans, have held a position of central interest in immunopathology for decades. First recognized in patients who had died from tuberculosis, these inflammatory cellular aggregat es, referred to as “tub ercules,” were identified as being comprised of large phagocytic cells or hist iocytes. Furthermore, a prominent feature of each granuloma is the formation of multinucleated giant cells, containing a peripheral zone of lymphocytes, with or without plasma cells.

This research was supported by Grant AI 12355–03 from the National Institute of Allergy and Inf ect ious Diseases, U.S. Public Health Service.

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Author information

Authors and Affiliations

  1. Institute for Pathobiology Center for Health Sciences, Lehigh University, Bethlehem, Pennsylvania, USA

    Thomas C. Cheng

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  1. Thomas C. Cheng
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Editor information

Editors and Affiliations

  1. United States Department of Agriculture, Manhattan, Kansas, USA

    Lee A. Bulla Jr.

  2. Lehigh University, Bethlehem, Pennsylvania, USA

    Thomas C. Cheng

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Cheng, T.C. (1978). A Study of Granuloma Formation by Molluscan Cells. In: Bulla, L.A., Cheng, T.C. (eds) Invertebrate Models for Biomedical Research. Comparative Pathobiology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1278-0_7

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  • DOI: https://doi.org/10.1007/978-1-4757-1278-0_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1280-3

  • Online ISBN: 978-1-4757-1278-0

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