Hormones and the Lung
Liggins reported in 1969 that premature lambs survived better if they had been treated in utero with glucocorticoids and suggested that glucocorticoids promoted foetal lung maturation and hence surfactant production. Subsequent studies have shown that glucocorticoid treatment of the foetus accelerates structural development of the lungs. Glucocorticoid receptors have been identified in higher concentration in the lung than any other foetal tissue. Using isolated cells, glucocorticoid receptors have been identified in the nuclei of lung fibroblasts and type II cells, but the concentration is no higher than in whole lung In keeping with this, the glucocorticoid-enhanced structural maturation of the lung is generalised, suggesting that all cell types are affected.
KeywordsGlucocorticoid Receptor Amniotic Membrane Pulmonary Epithelial Cell Basic Amine Pulmonary Endothelium
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