Abstract
It is estimated that 5% of all hospital admissions are due to drugs, that 10–18% of inpatients experience a drug reaction and that 3% of hospital deaths may be drug related (1,2). The lungs are often involved in these adverse reactions. Hutchinson et al (3) have described a potentially useful scheme for the operational assessment of whether or not a particular clinical manifestation represents an adverse drug reaction. This considers previous experience with the drug, alternative etiological candidates, the timing of events, drug levels, the effect of withdrawing the drug and rechallenge with the drug. The mechanism of a drug reaction may be based on overdosage, intolerence, a side ef f ect, a secondary ef f ect, hypersensitivity or idiosyncrasy (4). Drug reactions may be further classified according to the type of drug (analgesic, antibiotic, chemo-therapeutic agent, hormone, vasoactive agent, etc) or the pattern of disease. The last method is adopted here. Drugs may cause the following adverse pulmonary reactions:
-
(1)
Central depression of respiration
-
(2)
Broncho-constriction
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Shapiro, S., Slone, D., Lewis, G.P. & Jick, H. Fatal drug reactions among medical inpatients. Journal American Medical Association, 1971, 216, 467–472.
Friedman, G.D., Collen, M. F., Harris, L. E., van Brunt, E. E. & Davis, L. S. Experience in monitoring drug reactions in outpatients. Journal American Medical Association, 1971, 217, 567–572.
Hutchinson, T. A., Leventhal, J. M., Kramer, M. S., Karch, F. E., Lipman, A. G. & Feinstein, A. R, An algorithm for the operational assessment of adverse drug reactions. II Demonstration of reproducibility and validity. Journal American Medical Association, 1979, 242, 633–638.
Rosenheim, M. L., Editor. Sensitivity reactions to drugs. (Co-ed ited by Moulton, R.) Blackwell, Oxford, p.1.1958.
Crofton, J. W., Livingstone, J. L., Oswald, N. C. & Roberts, A. T. M. Pulmonary oesinophilia. Thorax, 1972, 7, 1–35.
Taskinen, E., Tukiainen, P. & Sovijarvi, A. R. A. Nitrofurantoin-induced alterations in pulmonary tissue. Acta path. microbiol. Scand. Sect. A. 1977, 85, 713–720.
Fiegenberg, D. S., Weiss, H. & Kirshman, H. Migratory pneumonia with eosinophilia. Arch. Intern. Med. 1967, 120, 85–88.
Katzenstein, A-L. A., Bloor, C. M. & Leibow, A. A. Diffuse alveolar damage — The role of oxygen, shock, and related factors. Amer. J. Path, 1976, 85, 210–224.
Heard, B. E. & Cooke, R. A. Busulphan lung. Thorax, 1968, 23, 187–193.
Vijeyaratnam, G. S. & Corrin, B. Fine structural alterations in the lungs of iprindoletreated rats. J. Path, 1974, 114, 233–239.
Heath, D., Smith, P. & Hasleton, P. S. Effects of chlorphentermine on the rat lung. Thorax, 1973, 28, 551–558.
Heppleston, A. G., Fletcher, K., Wyatt, I. Changes in the composition of the lung lipids and the “turnover” of dipalmitoyl lecithin in experimental alveolar lipoproteinosis induced by inhaled quartz. Brit. J. exp. Path., 1974, 384–395.
Salm, R. & Hughes, E. W. A case of chronic paraf f in pneumonitis. Thorax, 1970, 25, 762–768.
Kay, J. M., Smith, P. & Heath, D. Aminorex and the pulmonary circulation. Thorax, 1971, 26, 262–270.
Kay, J. M. & Heath, D. Observations on the pulmonary arteries and heart weight of rats fed on crotalaria spectabilis s eed s. J. Path. Bact. 1966, 92, 385–394.
Douglas, J. G., Munro, J. F., Kitchin, A. H., Muir, A. L. & Proudfoot, A. T. Pulmonary hypertension and Fenfluramine. Brit. Med. J., 1981, 283, 881–883.
Waller, B. F., Brownlee, W. J. & Roberts, W. C. Self-induced pulmonary granulomatosis. A consequence of intravenous injection of drugs intended for oral use. Chest, 1980, 78, 90–94.
Weber, W. R., Askin, F. B. & Dehner, L. P. Lung biopsy in pneumocystis carinii pneumonia. Am. J. Clin. Pathol. 1977, 67, 11–19.
Askin, F. B. & Katzenstein, A-L: A. Pneumocystis infection masquerading as diffuse alveolar damage. Chest, 1981, 79, 420–422.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer Science+Business Media New York
About this chapter
Cite this chapter
Corrin, B. (1984). Pathological Effects of Drugs on the Lung. In: Cumming, G., Bonsignore, G. (eds) Drugs and the Lung. Ettore Majorana International Science Series, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1269-8_14
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1269-8_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-1271-1
Online ISBN: 978-1-4757-1269-8
eBook Packages: Springer Book Archive