Human Thyroid Neoplasms Express ras p21 Protein at High Levels

  • M. Yiagnisis
  • K. Papadimitriou
  • D. A. Spandidos


In vitro and in vivo studies on cell transformation have revealed that recognizable steps in the process of malignant cell transformation can be achieved >by quantitative and/or qualitative changes in proto-cmcogene expression (for a review see ref. 1).


Follicular Adenoma Cellular Oncogene Colon Tunors Human Breast Lesion Noclonal Antibody 
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  1. 1.
    D.A. Spandidos. A unified theory for the develo rent of cancer. Biosci. Rep. 6:691 (1986).PubMedCrossRefGoogle Scholar
  2. 2.
    D.A. Spandidos and I.B. Kerr. Elevated expression of the hunan ras oncogene family in prema1 ignant and malignant tumors of the colorectum. Br. J. Cancer 49:681 (1984).PubMedCrossRefGoogle Scholar
  3. 3.
    J.J. Slamon, J.B. Dekernion, I.M. Verna and M.J. Cline. Expression of cellular oncogenes in human malignancies. Science 224:256 (1984).PubMedCrossRefGoogle Scholar
  4. 4.
    D.A. Spandidos and N.J. Agnantis. Htmnan malignant tumors of the breast as ca cared to their respective normal tissue have elevated expression of the Harvey ras oncogene. Anticancer Res. 4:269(1984).PubMedGoogle Scholar
  5. 5.
    D.A. Spandidos, A. Lamothe and J.N. Field. Multiple transcriptional activation of cellular oncogenes in human head ana neck solid tirs. Anticancer Res. 5: 221 (1984).Google Scholar
  6. 6.
    A. R. W. Williams, J. Piris, D.A. Spandidos and A. H. Wyllie. Lrm nohistochemical detection of the ras oncogene p21 product in an experimental tumor and in human colorectal neoplasms. Br. J. Cancer 52: 687(1985).PubMedCrossRefGoogle Scholar
  7. 7.
    N.J. Agnantis, C. Petraki, P. Markoulatos and D.A. Spandidos. Irro nohistochemical study of the ras oncogene expression in human breast lesions. Anticancer Res. 6: 1157(1986).PubMedGoogle Scholar
  8. 8.
    M. Barbacid. Ras genes. Ann. Rev. Biochem. 56: 779 (1987).PubMedCrossRefGoogle Scholar
  9. 9.
    J.L. Bos, E.R. Fearson, S.R. Hamilton, M. Barlaam-de Vries, J.H. Van Boom, A. van der Eb and B. Vogelstein. Prevalence of ras gene na tations in human colorectal cancers. Nature 327: 293(1987).PubMedCrossRefGoogle Scholar
  10. 10.
    K. Forrester, C. Airroguera, K. Han, W. E. Grizzle and M. Perucho. Detection of high incidence of K-ras oncogenes during Inman colon tumorigenesis. Nature 327: 298(1987).PubMedCrossRefGoogle Scholar
  11. 11.
    N.R. Learoine, E.S. Mayal l, F. S. Wyllie, C.J. Farr, D. Hughes, R.A. Padua, V. Thurston, E.D. Williams and D. Wynford-Thomas. Activated ras oncogenes in human thyroid cancers. Cancer Res. 48: 4459(1988).Google Scholar
  12. 12.
    O. Fasano, D. Birnbaum, L. Edl.und, J. Fogh and M. Wigler. New human transforming gene detected by a tuirorigenicity assay. Mol. Cell. Biol. 4:1695 (1984).PubMedGoogle Scholar
  13. 13.
    K. Papadimitriou, M. Yiagnisis, G. Tolls and D.A. Spandidos. Irrn unohi stochanical analysis of the ras oncogene protein in human thyroid product thyroi neoplasms. Anticancer Res. In press.Google Scholar
  14. 14.
    M. E. Furth, L.J. Davis, B. Fleurdelys arrl E.M. Scolnick. Monoclonal antibodies to the p21 products of the transforming gene of Harvey mourine sarcoma virus of the cellular ras gene family. J. Viral. 43: 294(1982).Google Scholar
  15. 15.
    N. R. Lemine, E. Syall, F.S. Wyllie and D. Wynford-Teas. High frequency of ras oncogene activation in benign and malignant human thyroid tumors. InP “Ras oncogenes” D.A. Spandidos, ed., Plenum Publ. Co. New York (1989).Google Scholar
  16. 16.
    P. Terrier, Z.-M. Sheng, M. Schlumberger, M. Tubiana, B. Caillou, J.-P. Travagli, P. Fragu, C. Parmentier and G. Riou. Structure and expression of c-myc and c-fos proto-oncogenes in thyroid carcinomas. Br. J. Cancer 57: 43(1988).PubMedCrossRefGoogle Scholar
  17. 17.
    R. Aasland, J.R. Lillehaug, R. Male, O. Josenaal, J.E. Varhaug and K. Kleppe. Expression of oncogenes in thyroid Murs: coexpression of c-erb2/neu and c-erbB. Br. J. Cancer 57: 358(1988).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • M. Yiagnisis
    • 1
  • K. Papadimitriou
    • 2
  • D. A. Spandidos
    • 1
    • 3
  1. 1.Biological Research CenterNational Hellenic Research FoundationAthensGreece
  2. 2.Ippokration General HospitalAthensGreece
  3. 3.The Beatson Institute for Cancer ResearchBearsden, GlasgowUK

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