Alterations of C-Ha-ras Gene are Associated with c-myc Activation in Human Cervical Cancers

  • Guy Riou
  • Michel Barrois
  • Zong-Mei Sheng
  • Danyi Zhou


In underdeveloped countries, mortality by cervical cancer is the first cause of mortality by cancer in women (Parkin et al., 1984), and continues to increase, in contrast with the situation found in developed countries where the general trend is towards a reduction in both incidence rates and mortality. However clinical observations of the last decade have suggested that there has been an increase in the number of cervical cancer patients aged under 35 years (Hall and Monaghan, 1983). Furthermore those cancers seem to be more aggressive. The biological behaviour of invasive carcinoma of the uterine cervix is not always predictable. Lymph node involvement is the most important prognostic factor, however the absence of invaded lymph nodes does not always guarantee recovery. Therefore it is quite important to find out new biological markers whose presence in early stages of cancers could predict the risk of recurrences.


Cervical Cancer Uterine Cervix Allele Loss Invasive Squamous Cell Carcinoma Normal Cervix 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Guy Riou
    • 1
  • Michel Barrois
    • 1
  • Zong-Mei Sheng
    • 1
  • Danyi Zhou
    • 1
  1. 1.Laboratoire de Pharmacologie Clinique et MoléculaireInstitut Gustave RoussyVillejuif, CedexFrance

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