High Frequency of ras Oncogene Activation in Benign and Malignant Human Thyroid Tumours

  • Nick R. Lemoine
  • Edward S. Mayall
  • Fiona S. Wyllie
  • David Wynford-Thomas
Chapter

Abstract

Tumours of the follicular epithelium of the human thyroid gland represent a multi-stage model of epithelial tumorigenesis with a low frequency of malignant progression (Williams 1979). Human thyroid follicular adenomas are genuine benign neoplasms which occur much more frequently and affect a younger age group than follicular carcinomas (Sommers 1982) , while at the other end of the spectrum, undifferentiated thyroid carcinomas are rare tumours which occur predominantly in the elderly and are thought to arise as a progression from differentiated carcinoma.

Keywords

Acute Myeloid Leukemia Follicular Carcinoma Human Thyroid Undifferentiated Carcinoma Follicular Adenoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Nick R. Lemoine
    • 1
  • Edward S. Mayall
    • 1
  • Fiona S. Wyllie
    • 1
  • David Wynford-Thomas
    • 1
  1. 1.CRC Thyroid Tumour Biology Research Group, Department of PathologyUniversity of Wales College of MedicineCardiffUK

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