High Frequency of ras Oncogene Activation in Benign and Malignant Human Thyroid Tumours

  • Nick R. Lemoine
  • Edward S. Mayall
  • Fiona S. Wyllie
  • David Wynford-Thomas


Tumours of the follicular epithelium of the human thyroid gland represent a multi-stage model of epithelial tumorigenesis with a low frequency of malignant progression (Williams 1979). Human thyroid follicular adenomas are genuine benign neoplasms which occur much more frequently and affect a younger age group than follicular carcinomas (Sommers 1982) , while at the other end of the spectrum, undifferentiated thyroid carcinomas are rare tumours which occur predominantly in the elderly and are thought to arise as a progression from differentiated carcinoma.


Acute Myeloid Leukemia Follicular Carcinoma Human Thyroid Undifferentiated Carcinoma Follicular Adenoma 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Nick R. Lemoine
    • 1
  • Edward S. Mayall
    • 1
  • Fiona S. Wyllie
    • 1
  • David Wynford-Thomas
    • 1
  1. 1.CRC Thyroid Tumour Biology Research Group, Department of PathologyUniversity of Wales College of MedicineCardiffUK

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