ras Oncogenes pp 269-274 | Cite as

Expression of ras Oncogene in Xenopus laevis

  • Ellen Z. Baum
  • Geraldine A. Bebernitz
  • Philip M. Sass


Oocytes of the South African clawed toad, Xenopus laevis, are an excellent model system for the study of various proto-oncogenes, including myc (1–4), src (5), and ras. The large size of Xenopus oocytes (~1.3 mm in diameter) permits the microinjection of biological material into these cells and subsequent biochemical analysis. In addition, the developmental processes of oogenesis and embryogenesis are easily monitored in the laboratory. In this communication, we summarize the effects of endogenous and exogenous ras protein on meiosis in oocytes. In addition, we present our preliminary characterization of the Xenopus homolog of mammalian Kirsten ras.


Adenylate Cyclase Xenopus Laevis Xenopus Oocyte Oocyte Maturation Xenopus Laevis Oocyte 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Ellen Z. Baum
    • 1
  • Geraldine A. Bebernitz
    • 1
  • Philip M. Sass
    • 1
  1. 1.Molecular Biology SectionLederle Laboratories, American Cyanamid CompanyPearl RiverUSA

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