Phenotypic and Cytogenetic Alterations in Human Skin Keratinocytes after Transfection with the Cellular Harvey-ras (c-Ha-ras) Oncogene
Since activated ras oncogenes have been detected in a variety of human tumors, experiments were performed to determine the causal role of the oncogene in the development of neoplasia. So far transformation experiments with the ras oncogene using human epithelial cells was only described twice. The obvious difficulty to transform these cells, although beeing the major target cell of cancer in men, prompted us to study the oncogene action in human epidermal cells in more detail.
KeywordsHaCaT Cell Human Epithelial Cell Specific Integration Site Human Epidermal Cell Cytogenetic Alteration
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