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Transcriptional Regulatory Sequences in the H-ras1 Gene

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ras Oncogenes

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Abstract

The H-ras1 gene is a member of the ras family (1, 2). It is the smallest of the family occupying approximately 3.5 kb of DNA. It encodes a protein of 21, 000 daltons which possesses GDP and GTP binding and GTPase activities. The viral p21 also exhibits autophcephorylating activity. Although the function of the ras p21 proteins is not known they are assumed to be signal transducers because of their structural and functional similarities with G proteins (1,2).

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References

  1. M. Barbacid. Ras genes. Ann. Rev. Biochem. 56 :779 (1987).

    Article  PubMed  CAS  Google Scholar 

  2. D.A. Spandidos. Ras oncogenes in cell transformation. ISI Atlas of Science. Immunology 1:1 (1988).

    CAS  Google Scholar 

  3. R. Muller, D.J. Slarron, J.M. Tremblay, M.J. Caine and I. Verna. Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature 299:640 (1982).

    Article  PubMed  CAS  Google Scholar 

  4. J. Leon, I. Guerrrero and A. Fellicer. Differential expression of the ras gene family in mice. Mol. Cell. Biol. 7 :1535 (1987).

    PubMed  CAS  Google Scholar 

  5. D.A. Spandidos and T. Dimitrov. High expression levels of ras p21 protein in normal mause heart tissues. Biosci. Rep. 5:1035 (1985).

    Article  PubMed  CAS  Google Scholar 

  6. M.E. Furth, T.H. Aldrich and C. Cordon-Cardo. Expression of ras proto-oncogene proteins in normal human tissues. Oncogene 1:47 (1987).

    PubMed  CAS  Google Scholar 

  7. D.A. Spandidos and I.B. Kerr. Elevated expression of the martian ras oncogene family in preznal ignant and malignant tumors of the colores turn. Br. J. Cancer 49:681 (1984).

    Article  PubMed  CAS  Google Scholar 

  8. D.A. Spandidos and N.J. Agnantis. Human malignant tumors of the breast as compared to their respective normal tissue have elevated expression of the Harvey ras oncogene. Anticancer Res. 4:269 (1984).

    PubMed  CAS  Google Scholar 

  9. D.A. Spandidos, A. Lanothe and J.N. Field. Multiple transcriptional activation of cellular oncogenes in the human head and neck solid tumors. Anticancer Res. 5 :221 (1985).

    PubMed  CAS  Google Scholar 

  10. A.R.W. Williams, J. Piris, D.A. Spandidos and A.H. Wyllie. Imnuuinýohistochemical detection of the ras oncogene Za21 product in an experimental tutrrýr and in human colorectal neoplasms. Br. J. Cancer 52:687 (1985).

    Article  PubMed  CAS  Google Scholar 

  11. M.V. Viola, F. Frorrcwitz, S. Oravez, S. Deb and J. Schlan. Ras oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma. J. Exp. Med. 161:1213 (1985).

    Article  PubMed  CAS  Google Scholar 

  12. N.J. Agnantis, C. Eetraki, P. Markoulataps and D.A. Spandidos. Immunohistochemical study of the ras oncogene expression in human breast lesions. Anticancer Res. 6 :1157 (1986).

    PubMed  CAS  Google Scholar 

  13. N.J. Agnantis, D.A. Spandidos, H. Mahera, P. Parissi, A. Kakkanas, A. Pintzas and N.X. Papaharalampous. I munohistochenical study of ras oncogene expression in er oretrial and cervical human lesion. Eur. J. Gyn. Oncol. 7:1 (1988).

    Google Scholar 

  14. T. Clair, W.R. Miller and Y.S. Cho-Chung. Prognostic signif icance of the expression of a ras protein with a molecular weight of 21,000 by hurran breast cancer. Cancer Res. 47 :5290 (1987).

    PubMed  CAS  Google Scholar 

  15. D.A. Spandidos. Oncogene activation in malignant transformation: A study of H-Ras in Mohan breast cancer. Anticancer Res. 7:991 (1987).

    PubMed  CAS  Google Scholar 

  16. E.H. Chang, M.E. Furth, E.M. Scolnick and D.R. Lary. Ttrigenic transformation of mammal ian cells induced by a normal human gene homologous to the oncogene of Harvey muririne sarcam a virus. Nature 297:478 (1982).

    Article  Google Scholar 

  17. D.A. Spandidos and N.M. Wilkie. Malignant transformation of early passage rodent cells >by a single mutated human oncogene. Nature 310:469 (1984).

    Article  PubMed  CAS  Google Scholar 

  18. D.A. Lidos. Mechanism of carcinogenesis: the role of oncogenes, transcriptional enhancers and growth factors., Anticancer Res. 5:485 (1985).

    Google Scholar 

  19. D.J. Capon, E.Y. Chen, A.D. Levinson, P.H. Seeburg and D.V. Goeddel. Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature 302:33 (1983).

    Article  PubMed  CAS  Google Scholar 

  20. S. Ishii, G.T. Merlino and I. Pastan. Promoter region of the huoman Harvey ras proto-oncogene: similarity to the EFG receptor proto-on cogene promoter. Science 230:1378 (1985).

    Article  PubMed  CAS  Google Scholar 

  21. S. Ishii, J.T. Kadonaga, R. Tjian, J.N. Brady, G.T. Merlino and I. Pastan. Binding of the Spi transcription factor by the human Harvey ras1 protooncogene promoter. Science 232:1410 (1986).

    Article  PubMed  CAS  Google Scholar 

  22. D.A. Spandidos, R.A.B. Nicholls, N.M. Wilkie and A. Pintzas. Phorbol ester responsive H-1 gene pranoter contains multiple TPA-inducible/AF-1 binding consensus sequence elements. FEBS Letters. In Press.

    Google Scholar 

  23. H. Honkawa, W. Masahashi, S. Hashimoto and T. Hashimoto-Gotoh. Identification of the principal promoter sequence of the c-H-ras transforming oncogene: Deletion analysis of the 5’-flanking region by focus formation assay. Mol. Cell. Biol. 7 :2933 (1987).

    PubMed  CAS  Google Scholar 

  24. D.A. ados and M. Riggio. Promoter and enhancer like activity at the 5’-end of normal and 724 Ha-ras1 genes. FEBS Lett. 203–169 (1986).

    Google Scholar 

  25. W.S. Trimble and N. Hozumi. Deletion analysis of the c-Ha-ras oncogene promoter. FEES Lett. 219:70 (1987).

    Article  CAS  Google Scholar 

  26. D.A. Spandidos and L. Holmes. Transcriptional enhancer activity in the variable tandem repeat DNA sequence clawnstream of the human Ha-ras1 gene. FEBS Lett. 218:41 (1987).

    Article  PubMed  CAS  Google Scholar 

  27. J.B. Cohen, M.V. Walter and A.D. Levinson. A repetitive sequence element 3’ of the human c-Ha-ras1 gene has enhancer activity. J. Cell. Phys. Suppl. 5:75 (1987).

    Article  Google Scholar 

  28. D.A. Spandidos and A. Pintzas. Differential potency and trans-activation of normal and mutant 724 human H-ras1 gene prompters. FEBS Letters 232:269 (1988).

    Article  PubMed  CAS  Google Scholar 

  29. J.B. Cohen and A.D. Levinson. A point mutation in the last intron responsible for increased expression and transforming activity of the c-Ha-ras oncogene. Nature 334:119 (1988).

    Article  PubMed  CAS  Google Scholar 

  30. J.L. Bos, E.R. Fearon, S.R. Hamilton, M. Barlaam-de Vries, J.H. van Boars, A. Van der Flo and B. Vogelstein. Prevalence of ras gene mutations in human colorectal cancers. Nature 327 :293 (1987).

    Article  PubMed  CAS  Google Scholar 

  31. K. Forrester, C. Alrroguera, K. Han, W.E. Grizzle and M. Perucho. Detecticn of high inciclerice of k-ras oncogenes during human colon turrorigenesis. Nature 327:298 (1987).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. The Beatson Institute for Cancer Research, Garscube Estate, Bearsden Glasgow, G61 1BD, Scotland, UK

    Derretrios A. Spandidos

  2. Biological Research Center, National Hellenic Research Foundation, 48 vas Constantinou Avenue, Athens, 11635, Greece

    Derretrios A. Spandidos

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  1. Derretrios A. Spandidos
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Editors and Affiliations

  1. The Beatson Institute, Cancer Research, Glasgow, UK

    Demetrios Spandidos

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© 1989 Springer Science+Business Media New York

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Spandidos, D.A. (1989). Transcriptional Regulatory Sequences in the H-ras1 Gene. In: Spandidos, D. (eds) ras Oncogenes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1235-3_2

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  • DOI: https://doi.org/10.1007/978-1-4757-1235-3_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1237-7

  • Online ISBN: 978-1-4757-1235-3

  • eBook Packages: Springer Book Archive

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