Suppression of Temperature-Sensitive RAS in S.cerevisiae by a Putative Protein Kinase

  • Elena Carra
  • Pietro Masturzo
  • Alessandra Vitelli
  • Emanuele Burderi
  • Irene Lambrinoudaki
  • Emmanuele De Vendittis
  • Regina Zahn
  • Ottavio Fasano

Abstract

In the yeast Saccharomyces cerevisiae, the RAS1 and RAS2 proteins (collectively denominated RAS) are involved in the regulation of growth, metabolism, and adaptative responses (for a review, see Tamanoi, 1988). These effects are mediated, at least in part, by the adenylate cyclase/protein kinase pathway (Toda et al., 1985; Broek et al., 1985). In fact, the growth arrest caused by the inactivation of the RAS1 and RAS2 genes can be bypassed by mutations which constitutively activate the function of the adenylate cyclase (CYR1) and of three distinct but homologous cyclic AMP-dependent protein kinases (TPK1, TPK2, and TPK3) (Matsumoto et al., 1982; Toda et al., 1985; Kataoka et al., 1985; De Vendittis et al., 1986; Toda et al., 1987a-b).

Keywords

Adenylate Cyclase Catalytic Subunit Amino Acid Sequence Similarity RAS2 Gene Putative Protein Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Elena Carra
    • 1
  • Pietro Masturzo
    • 1
  • Alessandra Vitelli
    • 1
  • Emanuele Burderi
    • 1
  • Irene Lambrinoudaki
    • 1
  • Emmanuele De Vendittis
    • 1
  • Regina Zahn
    • 1
  • Ottavio Fasano
    • 1
  1. 1.Differentiation ProgrammeEuropean Molecular Biology LaboratoryHeidelbergGermany

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