Uncertainty About the Incubation Period of AIDS and Its Impact on Backcalculation

  • Peter R. Bacchetti
  • Mark R. Segal
  • Nicholas P. Jewell

Abstract

We analyze three sets of doubly-censored cohort data on incubation times, estimating incubation distributions using semiparametric methods and assessing the comparability of the estimates. Weibull models appear to be inappropriate for at least one of the cohorts, and the estimates for the different cohorts are substantially different. We use these estimates as inputs for backcalculation, using a nonparametric method based on maximum penalized likelihood. The different incubations all produce fits to the reported AIDS counts that are as good as the fit from a nonstationary incubation distribution that models treatment effects, but the estimated infection curves are very different. We also develop a method for estimating nonstationarity as part of the backcalculation procedure and find that such estimates also depend very heavily on the assumed incubation distribution. We conclude that incubation distributions are so uncertain that meaningful error bounds are difficult to place on backcalculated estimates and that backcalculation may be too unreliable to be used without being supplemented by other sources of information on HIV prevalence and incidence.

Keywords

Vaccine Trial Nonstationary Model Reporting Delay Incubation Data Incubation Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Peter R. Bacchetti
    • 1
  • Mark R. Segal
    • 1
  • Nicholas P. Jewell
    • 2
  1. 1.Department of Epidemiology and BiostatisticsUniversity of CaliforniaSan FranciscoUSA
  2. 2.Group in BiostatisticsUniversity of CaliforniaBerkeleyUSA

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