Thrombosis pp 145-163 | Cite as

Vessel Injury and Atherosclerosis

  • Sean Moore
  • Ihor O. Ihnatowycz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 102)


Repeated endothelial injury causes lipid-rich lesions in animals on a normal diet. In severely thrombocytopenic animals these lesions do not form or are markedly inhibited. The occurrence of lipid in some experimental designs is related to continued or repeated deposition of thrombus. Lipid deposition occurs in areas where endothelium is repeatedly removed and regrows. Repeated deposition of thrombus may bring about changes in the metabolism of the neo-intima which favor lipid deposition.


Smooth Muscle Cell Endothelial Injury Smooth Muscle Cell Proliferation Vessel Injury Fatty Streak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Sean Moore
    • 1
  • Ihor O. Ihnatowycz
    • 1
  1. 1.Department of PathologyMcMaster UniversityHamiltonCanada

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