Thrombosis pp 135-143 | Cite as

Platelets, Endothelium, and Smooth Muscle Cells in Atherosclerosis

  • Russell Ross
  • Laurence Harker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 102)


A factor derived from platelets stimulates the proliferation of smooth muscle cells in culture, and is likely important in stimulating smooth muscle proliferative lesions of atherogenesis in vivo The platelet factor is produced during platelet aggregation when serum is made from whole blood. In vitro,smooth muscle cells are potent aggregating agents for platelets, while endothelial cells can inhibit this aggregating effect. Better understanding of the interactions of platelets, smooth muscle cells, and endothelium would facilitate developing effective means of intervening in or preventing the smooth muscle proliferative lesions of atherosclerosis.


Smooth Muscle Cell Platelet Adherence Artery Wall Platelet Factor Arterial Smooth Muscle Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Russell Ross
    • 1
  • Laurence Harker
    • 1
  1. 1.Departments of Pathology and MedicineUniversity of Washington, School of MedicineSeattleUSA

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