Thrombosis pp 299-310 | Cite as

Relevance of in Vitro and Animal Models to Clinical Thrombosis

  • Paul Didisheim
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 102)


I have been thinking during this conference about the relevance to clinical thrombosis of the various experimental models that have been discussed. I now feel somewhat like the cartoon scientist sitting at the bench of his cluttered laboratory, gazing into space. In the background one colleague says to another: “Since he became an Aristotelian, he has stopped experimenting, and he now believes that all knowledge comes from thought alone.” Perhaps it is unjustified to be that negative about the methods that have been described; yet it is vitally important to consider whether the experimental model which each of us doggedly espouses has any relevance to thrombosis in the human. This brings me to the definition of relevance. Dr. Spaet says what is relevant is the work being done in his laboratory.


Sickle Cell Anemia Protein Adsorption Platelet Adhesion Prosthetic Heart Valve Sickle Cell Anemia Patient 
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    Didisheim P: Animal models useful in the study of thrombosis and antithrombotic agents. In PROGRESS IN HEMOSTASIS AND THROMBOSIS, Vol. 1, edited by Spaet TH. New York, Grune and Stratton, 1972, pp. 165–197.Google Scholar
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    Wiseman R: SEVERAL CHIRURGICAL TREATISES ( ed. 2 ). Flesher and Macock for Royston, London, 1676, p. 4.Google Scholar
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    Rowntree LG, Shionoya T: Studies in experimental thrombosis. I. A method for the direct observation of extracorporeal thrombus formation. J EXP MED 46: 7–12, 1927.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Paul Didisheim
    • 1
  1. 1.Thrombosis Research Laboratory, Department of Laboratory MedicineMayo ClinicRochesterUSA

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