Thrombosis pp 257-264 | Cite as

The Role of Platelets in Transient Ischemic Attacks and Cerebral Vascular Accidents

  • H. J. M. Barnett
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 102)

Abstract

In a 5½-year study in 585 patients, aspirin, 1200 mg/day, reduced by 50% the risk of stroke or death in men who had experienced at least one episode of neurological disability in carotid or vertebral-basilar territory. Adding sulfinpyrazone to aspirin did not improve the results, and sulfinpyrazone alone was no better than placebo. Women did not experience the same benefit; aspirin did not reduce their risk of stroke or death.

Keywords

Cerebral Ischemia Transient Ischemic Attack Stroke Prevention Transient Cerebral Ischemia Cerebral Vascular Accident 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Fisher CM: Observations of the fundus oculi in transient monocular blindness. NEUROLOGY 9: 333: 347, 1959.Google Scholar
  2. 2.
    Russell RWR: Observations on the retinal blood vessels in monocular blindness. LANCET 2: 1422–1428, 1961.PubMedCrossRefGoogle Scholar
  3. 3.
    Smythe HA, Ogryzlo MA, Murphy EA, Mustard JF: The effect of sulfinpyrazone (Anturan) on platelet economy and blood coagulation in man. CAN MED ASSOC J 92: 818–821, 1965.PubMedGoogle Scholar
  4. 4.
    Weiss HJ, Aledort LM: Impaired platelet connective-tissue reaction in man after aspirin ingestion. LANCET 2: 495–497, 1967.PubMedCrossRefGoogle Scholar
  5. 5.
    Zucker MB, Peterson J: Inhibition of adenosine diphosphate induced aggregation and other platelet functions by acetylsalicylic acid ingestion. PROC SOC EXP BIOL MED 127: 547–551, 1968.PubMedGoogle Scholar
  6. 6.
    Barnett HJM: Transient cerebral ischemia: Pathogenesis,prognosis and management. ANN R COLL PHYSICIANS SURG CAN 7: 153–173, 1974.Google Scholar
  7. 7.
    Gunning AJ, Pickering GW, Robb-Smith ART, Russell, RR: Mural thrombosis of the internal carotid artery and subsequent embolism. Q J MED 33: 155–195, 1964.PubMedGoogle Scholar
  8. 8.
    Barnett HJM: Pathogenesis of transient ischemic attacks. In: CEREBROVASCULAR DISEASES, edited by Scheinberg P. New York, Raven Press, 1976, pp. 1–21.Google Scholar
  9. 9.
    Warren BA, Vales 0: Electron microscopy of the sequence of events in the atheroembolicocclusion of cerebral arteries in an animal model. BR J EXP PATROL 56: 205–215, 1975.Google Scholar
  10. 10.
    Whisnant JP, Matsumoto NM, Elseback LR: Transient cerebral ischemia attacks in a community. MAYO CLIN PROC 48: 194–198, 1973.PubMedGoogle Scholar
  11. 11.
    Drake WE, Drake MAL: Clinical and angiographic correlates of cerebrovascular insufficiency. AM J MED 45: 253–270, 1968.PubMedCrossRefGoogle Scholar
  12. 12.
    Millikan CH: Treatment of occlusive cerebrovascular disease. In: CEREBROVASCULAR SURVEY REPORT FOR JOINT COUNCIL SUBCOMMITTEE ON CEREBROVASCULAR DISEASE, NATIONAL INSTITUTE OF NEUROLOGICAL AND COMMUNICATIVE DISORDERS AND STROKE AND NATIONAL HEART AND LUNG INSTITUTE (revised), edited by Siekert RG, Rochester, Whiting Press Inc., 1976, pp. 141–171.Google Scholar
  13. 13.
    Friedman GD, Wilson WS, Mosier JM, Colandrea MA, Nichaman MZ: Transient ischemic attacks in a community. JAMA 210: 1428–1434, 1969.PubMedCrossRefGoogle Scholar
  14. 14.
    Cartlidge NEF, Whisnant JP, Elveback LR: Carotid and vertebral-basilar transient cerebral ischemic attacks. MAYO CLIN PROC 54: 117–120, 1977.Google Scholar
  15. 15.
    Marshall J: The natural history of transient ischemic cerebro-vascular attacks. Q J MED 33: 309–324, 1964.PubMedGoogle Scholar
  16. 16.
    Kishore PRS, Chase NE, Kricheff II: Ulcerated atheroma of carotid artery and cerebral embolism. In: ASPIRIN, PLATELETS AND STROKE, edited by Fields WS, Hass WR. St. Louis, Warren H. Green, 1971, pp. 13–27.Google Scholar
  17. 17.
    Eisenberg RL, Nemzek WR, Moore WE, Mani RL: Relationship of transient ischemic attacks and angiographically demonstrable lesions of carotid artery. STROKE 8: 483–486, 1977.PubMedCrossRefGoogle Scholar
  18. 18.
    Genton E, Barnett HJM, Fields WS, Gent M, Hoak JC: Cerebral ischemia: The role of thrombosis and of antithrombotic therapy. STROKE 8: 147–175, 1977.CrossRefGoogle Scholar
  19. 19.
    Fields WS, Lemak NA, Frankowski RF, Hardy RJ: Controlled trial of aspirin in cerebral ischemia. STROKE 3: 301–316, 1977.CrossRefGoogle Scholar
  20. 20.
    Barnett HJM: Platelets, drugs and cerebral ischemia. In: PLATELETS, DRUGS AND THROMBOSIS, edited by Hirsh J. Basel, S. Karger, 1975, pp. 232–252.Google Scholar
  21. 21.
    Gent M: Canadian cooperative study of recent recurrent presumed cerebral emboli (RRPCE). Design and organization of the study. In: PLATELETS, DRUGS AND THROMBOSIS, edited by Hirsh J. Basel, S. Karger, 1975, pp. 253–257.Google Scholar
  22. 22.
    Canadian Stroke Study Group: A randomized trial of aspirin and sulfinpyrazone in threatened stroke. I.Methods and neurological results. N ENGL J MED (In Press).Google Scholar

Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • H. J. M. Barnett
    • 1
  1. 1.Department of Clinical Neurological SciencesUniversity of Western OntarioLondonCanada

Personalised recommendations