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The Roles of Endothelium, Platelets,and Smooth Muscle Cells in Intimal Healing

  • Chapter
Thrombosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 102))

Abstract

The continual remodeling of the artery wall significantly narrows the lumen. It contributes to the development of atherosclerotic plaque through the incorporation of lipid into the arterial intima. The steps in the repair of arterial intima include platelet accumulation followed by leukocyte attachment to denuded areas, smooth muscle migration from the media, deposition of extracellular connective tissue components, and endothelial proliferation from undamaged artery branches. Intimal growth and regression seem related to re-endothelialization, platelets, the pituitary, and unidentified factors.

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References

  1. Ahrens EH: Drugs spotlight program: The management of hyperlipidemia: Whether, rather than how. ANN INTERN MED 85: 8793, 1976.

    Google Scholar 

  2. Ross R, Glomset JA: The pathogenesis of atherosclerosis. N ENGL J MED 295: 369–377, 1976.

    Article  PubMed  CAS  Google Scholar 

  3. Geer JC, Haust MD: SMOOTH MUSCLE CELLS IN ATHEROSCLEROSIS. MONOGRAPH ON ATHEROSCLEROSIS, Vol. 2. Basel, S. Karger, 1972.

    Google Scholar 

  4. Arteriosclerosis. Report by National Heart and Lung Institute Task Force on Arteriosclerosis. 1972. DHEW Publication No. 72–219, 13.

    Google Scholar 

  5. French JE: Atherosclerosis in relation to the structure and function of the arterial intima, with special reference to the endothelium. INT REV EXP PATHOL 5: 253–353, 1966.

    PubMed  CAS  Google Scholar 

  6. Stemerman MB: Vascular intimai components: Precursors of thrombosis. PROG HEMOSTASIS THROMBO 2: 1–47, 1974.

    CAS  Google Scholar 

  7. Wolinsky H, Galgov S: Nature of species differences in the medial distribution of aortic vasa vasorum in mammals. CIRC RES 20: 409–421, 1967.

    Article  PubMed  CAS  Google Scholar 

  8. Ross R: The smooth muscle cell, II. Growth of smooth muscle in culture and formation of elastic fibers. J CELL BIOL 50: 172–186, 1971.

    Article  PubMed  CAS  Google Scholar 

  9. Jorres I, Majno G: Cellular breakdown within the arterial wall. An ultrastructural study of the coronary artery in young and aging rats. VIRCHOWS ARCH [PATHOL ANAT] 364: 11 1127, 1974.

    Google Scholar 

  10. Frist S, Stemerman MB: Arterial Growth and Development, In VASCULAR NEUROEFFECTOR SYSTEMS, edited by Bevan JA. S.J. Karger, 1977, pp. 19–27.

    Google Scholar 

  11. Haust MD, More RH: Development of modern theories on the pathogenesis of atherosclerosis. In THE PATHOGENESIS OF ATHEROSCLEROSIS, edited by Wissler RW, Geer JG. Baltimore, Williams and Wilkins Co., 1972, pp. 1–29.

    Google Scholar 

  12. Schwartz SM, Stemerman MB, Benditt EP: The aortic intima. II. Repair of the aortic lining after mechanical denudation. AM J PATHOL 81: 15–48, 1975.

    PubMed  CAS  Google Scholar 

  13. Poole JCF, Cromwell SB, Benditt EP: Behavior of smooth muscle cells and formation of extracellular structures in the reaction of arterial walls to injury. AM J PATHOL 62: 391–414, 1971.

    PubMed  CAS  Google Scholar 

  14. Mustard JF, Packham MA: The role of blood and platelets in atherosclerosis and complications of atherosclerosis. THROMB DIATH HAEMORRH 33: 444–456, 1975.

    PubMed  CAS  Google Scholar 

  15. Stemerman MB: Factors governing the healing response of injured arteries. ANN N Y ACAD SCI 283: 310–316, 1977.

    Article  Google Scholar 

  16. Minick CR, Murphy GE: Experimental induction of atheroarteriosclerosis by the synergy of allergic injury to arteries and lipid-rich diet. II. Effect of repeatedly injected foreign proteins in rabbits fed a lipid-rich, cholesterol-poor diet. AM J PATHOL 73: 265–300, 1973.

    PubMed  CAS  Google Scholar 

  17. Reichl D, Simons LA, Myant NB, Pflug JJ, Mills GL: The lipids and lipoproteins of human peripheral lymph, with observations on the transport of cholesterol from plasma and tissue into lymph. CLIN SCI MOL MED 45: 313–329, 1973.

    PubMed  CAS  Google Scholar 

  18. Baumgartner HR, Studer A: Folgen des Gefässkatheterismus am normo-und hypercholesterinaemischen Kaninchen. PATHOL MICROBIOL 29: 393–405, 1966.

    CAS  Google Scholar 

  19. Stemerman MB: Thrombogenesis of the rabbit arterial plaque: An electron microscopic study. AM J PATHOL 73: 7–26, 1973.

    PubMed  CAS  Google Scholar 

  20. Stemerman MB, Ross R: Experimental arteriosclerosis. 1. Fibrous plaque formation in primates, an electron microscopic study. J EXP MED 136: 769–789, 1972.

    Article  PubMed  CAS  Google Scholar 

  21. Burns ER, Spaet RH, Stemerman MB: Intimai cell proliferation following de-endothelialization of the rabbit aorta: A self-limiting process. CLIN RES 24: 437A, 1976. [Abstract].

    Google Scholar 

  22. Wight TN, Ross R: Proteoglycans in primate arteries. II. Synthesis and secretion of glycosaminoglycans by arterial smooth muscle cells in culture. J CELL BIOL 67: 675–686, 1975.

    Article  PubMed  CAS  Google Scholar 

  23. Jaffe EA, Minick CR, Adelman B, Becker CG, Nachman R: Synthesis of basement membrane collagen by cultured human endothelial cells. J EXP MED 144: 209–225, 1976.

    Article  PubMed  CAS  Google Scholar 

  24. Stemerman MB, Pitlick FA, Dembitzer HB: Electron microscopic immunohistochemical identification of endothelial cells in the rabbit. CIRC RES 38: 146–156, 1976.

    Article  PubMed  CAS  Google Scholar 

  25. Stemerman MB, Spaet TH, Pitlick FA, Cintron J, Lejnieks I, Tiell ML: Intimai healing: The pattern of reendothelialization and intimai thickening. AM J PATHOL 87: 125–137, 1977.

    PubMed  CAS  Google Scholar 

  26. Muggii R, Baumgartner HR: Pattern of membrane invaginations at the surface of smooth muscle cells of rabbit arteries. EXPERIENTIA 28: 1212–1214, 1972.

    Article  Google Scholar 

  27. Gospodarowicz D, Moran JS: Mitogenic effect of fibroblast growth factor on early passage cultures of human and murine fibroblasts. J CELL BIOL 66: 451–456, 1975.

    Article  PubMed  CAS  Google Scholar 

  28. Antoniades HN, Scher CD: Radioimmunoassay of a human growth factor for Balb/C-3T3 cells: Derivation from platelets. PROC NATL ACAD SCI 74: 1973–1977, 1977.

    Article  PubMed  CAS  Google Scholar 

  29. Antoniades HN, Scher CD: Growth factors derived from human serum, human platelets and human pituitary; properties and immunologic cross-reactivity. NATL CANCER INST MONOGRAPH No. 48 (In Press).

    Google Scholar 

  30. Friedman RJ, Stemerman MB, Wenz B, Moore S, Gauldie J, Gent M Tiell ML, Spaet TH: The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization. J CLIN INVEST 60: 1191–1201, 1977.

    Google Scholar 

  31. Tiell ML, Stemerman MB: Inhibition of aortic intimal hyperplasia by hypophysectomy in rats. CLIN RES 24: 321A, 1976. [Abstract].

    Google Scholar 

  32. Rhee CY, Spaet TH, Stemerman MB, Lajam F, Shiang HH, Caruso E, Litwak RS: Estrogen suppression of surgically induced vascular intimal hyperplasia in rabbits. J LAB CLIN MED 90: 7784, 1977.

    Google Scholar 

  33. Fisher-Dzoga K, Wissler RW: Stimulation of proliferation in stationary primary cultures of monkey aortic smooth muscle cells. Part 2. Effect of varying concentrations of hyperlipidemic serum and low density lipoproteins of varying dietary fat origins. ATHEROSCLEROSIS 24: 515–525, 1976.

    Article  Google Scholar 

  34. Armstrong ML, Megan MB: Arterial fibrous proteins in cynomolgus monkeys after atherogenic and regression diets. CIRC RES 36: 256–261, 1975.

    Article  PubMed  CAS  Google Scholar 

  35. Mann GV: Current concepts. Diet-Heart: End of an era. N ENGL J MED 297: 644–650, 1977.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Beth Israel Hospital, Boston, MA, USA

    Michael B. Stemerman M.D.

Authors
  1. Michael B. Stemerman M.D.
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Editor information

Editors and Affiliations

  1. Department of Medicine, Section of Hematology, Temple University, Health Sciences Center, 19140, Philadelphia, PA, USA

    H. James Day M.D.

  2. Diabetes and Atherosclerosis Research, The Upjohn Company, 49001, Kalamazoo, MI, USA

    Basil A. Molony M.D. , Edward E. Nishizawa Ph.D.  & Ronald H. Rynbrandt Ph.D. ,  & 

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© 1978 Springer Science+Business Media New York

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Stemerman, M.B. (1978). The Roles of Endothelium, Platelets,and Smooth Muscle Cells in Intimal Healing. In: Day, H.J., Molony, B.A., Nishizawa, E.E., Rynbrandt, R.H. (eds) Thrombosis. Advances in Experimental Medicine and Biology, vol 102. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1217-9_11

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  • DOI: https://doi.org/10.1007/978-1-4757-1217-9_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1219-3

  • Online ISBN: 978-1-4757-1217-9

  • eBook Packages: Springer Book Archive

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