Thrombosis pp 175-185 | Cite as

The Roles of Endothelium, Platelets,and Smooth Muscle Cells in Intimal Healing

  • Michael B. Stemerman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 102)

Abstract

The continual remodeling of the artery wall significantly narrows the lumen. It contributes to the development of atherosclerotic plaque through the incorporation of lipid into the arterial intima. The steps in the repair of arterial intima include platelet accumulation followed by leukocyte attachment to denuded areas, smooth muscle migration from the media, deposition of extracellular connective tissue components, and endothelial proliferation from undamaged artery branches. Intimal growth and regression seem related to re-endothelialization, platelets, the pituitary, and unidentified factors.

Keywords

Smooth Muscle Cell Evans Blue Smooth Muscle Cell Proliferation Platelet Factor Internal Elastic Lamina 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Michael B. Stemerman
    • 1
  1. 1.Beth Israel HospitalBostonUSA

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