Thrombosis pp 165-173 | Cite as

Delayed Consequences of Endothelial Removal from Rabbit Aortae

  • Theodore H. Spaet
  • Choo Rhee
  • Charlene Geiger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 102)

Abstract

One year after de-endothelialization of rabbit aorta by a balloon catheter, the damaged areas show arteriosclerotic thickening. In the study described here, aortae from six rabbits were examined 2 years after the single injury. Three had advanced atherosclerotic lesions. All the animals had been fed standard rabbit chow, and the five tested did not have hypercholesterolemia when they were sacrificed. Apparently vascular injury alone is sufficient basis for development of atherosclerotic disease in the rabbit.

Keywords

Atherosclerotic Lesion Balloon Catheter Evans Blue Original Magnification Intimal Thickening 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Spaet TH, Stemerman MB, Veith FJ, Lejnieks I: Intimai injury and regrowth in the rabbit aorta: Medial smooth muscle cells as a source of neointima. CIRC RES 36: 58–70, 1975.PubMedCrossRefGoogle Scholar
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    Stemerman MB, Spaet TH, Pitlick F, Cintron J, Lejnieks I, Tiell ML: Intimal healing. The pattern of reendothelialization and intimal thickening. AM J PATHOL 87: 125–137, 1977.PubMedGoogle Scholar
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Theodore H. Spaet
    • 1
  • Choo Rhee
    • 1
  • Charlene Geiger
    • 1
  1. 1.Hematology Division, Department of MedicineMontefiore Hospital and Medical Center, and the Albert Einstein College of MedicineBronxUSA

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