Abstract
Plague is a zoonotic disease of rodents and their fleas caused by Yersinia pestis. Fleas infected by feeding on a diseased rodent may transfer the infection to other rodents and to man. Commonly, the initial response, in man and in rodent, is a lymphadenitis, adjacent to the site of the bite. If not contained at this level, there is bloodstream invasion, and a frequent complication is involvement of the lungs. This can result in direct patient-to-person transfer of Y. pestis. There can be either a few sporadic secondary cases or devastating epidemics. In the flea-transferred form (bubonic) prior to 1940, the death rate was 50–70%. In the pneumonic transfer form, practically all patients were expected to die. The disease was greatly feared, and this fear continues, despite the ability of today’s drugs to control the disease.
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Suggested Reading
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Tigertt, W.D. (1991). Plague. In: Evans, A.S., Brachman, P.S. (eds) Bacterial Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1211-7_24
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DOI: https://doi.org/10.1007/978-1-4757-1211-7_24
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