Electrogenesis of Pacemaker Potential as Revealed by AV Nodal Experiments

  • H. Irisawa
  • A. Noma
  • S. Kokubun
  • Y. Kurachi
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 34)

Abstract

The atrioventricular (AV) node has two vitally important functions. One is its role in the conduction through atrium to ventricle. The slow conduction of excitation within the node [1, 2] provides an adequate time delay between the contraction of atria and that of ventricles and enables the heart to function as an efficient pump. Another function of the AV node is its secondary pacemaker activity. When the sinoatrial (SA) node fails to control cardiac rhythm, as a result either of depressed automaticity or impaired conduction, the AV node functions as a pacemaker of the heart.

Keywords

Versus Node Tyrode Solution Ventricular Cell Pacemaker Potential Transient Hyperpolarization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hoffman BF, Cranefield PF: Electrophysiology of the heart. Mount Kisco NY: Futura, 1960 [reprinted 1976 ].Google Scholar
  2. 2.
    Matsuda K, Hoshi T, Kameyama S: Action potential of the atrioventricular node (Tawara). Tohoku J Exp Med 68: 8, 1958.PubMedCrossRefGoogle Scholar
  3. 3.
    Tawara S: Das Reizleitungssystem des Saugetierherzens. Jena: Gustav Fischer, 1906.Google Scholar
  4. 4.
    Noma A, Irisawa H: Membrane current in the rabbit sinoatrial node cell as studied by the double micro-electrode method. Pflugers Arch 364: 45–52, 1976.PubMedCrossRefGoogle Scholar
  5. 5.
    Irisawa H: Comparative physiology of the cardiac pacemaker mechanism. Physiol Rev 58: 461–498, 1978.PubMedGoogle Scholar
  6. 6.
    Brown HF: Electrophysiology of the sinoatrial node. Physiol Rev 62: 505–530, 1982.PubMedGoogle Scholar
  7. 7.
    Paes de Carvalho A, De Almeida DF: Spread of activity through the atrioventricular node. Circ Res 8: 801–809, 1960.CrossRefGoogle Scholar
  8. 8.
    Akiyama T, Fozzard HA: (1979) Ca and Na selectivity of the active membrane of rabbit AV node cells. Am J Physiol 236: C1 - C8, 1979.PubMedGoogle Scholar
  9. 9.
    Ruiz-Ceretti E, Ponce Zumino A: Action potential changes under varied (Na)0 and (Ca)0 indicating the existence of two inward currents in cells of the rabbit atrioventricular node. Circ Res 39: 326–336, 1976.PubMedCrossRefGoogle Scholar
  10. 10.
    Zipes DP, Mendez C: Action of manganese ions and tetrodotoxin on atrioventricular nodal transmembrane potentials in isolated rabbit hearts. Circ Res 32: 447–454, 1973.PubMedCrossRefGoogle Scholar
  11. 11.
    Mendez C: The slow inward current and AV nodal propagation. In: Zipes DP, Bailey JC, Elharrar V (eds) The slow inward current and cardiac arrhythmias. The Hague: Martinus Nijhoff, 1980, pp 285–294.CrossRefGoogle Scholar
  12. 12.
    Hoffman BF: The specialized tissues of the heart. Paes de Carvalho A, De Mello WC, Hoffman BB (eds). Amsterdam: Elsevier, 1961.Google Scholar
  13. 13.
    Shigeto N, Irisawa H: Slow conduction in the atrioventricular node of the cat: a possible explanation. Experientia 28: 1442–1443, 1972.PubMedCrossRefGoogle Scholar
  14. 14.
    Shigeto N, Irisawa H: Effect of polarization on the action potentials of the rabbit AV node cells. Jpn J Physiol 24: 605–616, 1974.PubMedCrossRefGoogle Scholar
  15. 15.
    Kokubun S, Nishimura M, Noma A, Irisawa H: Membrane currents in the rabbit atrioventricular node cells. Pflugers Arch 393: 15–22, 1982.PubMedCrossRefGoogle Scholar
  16. 16.
    Kurachi Y, Noma A, Irisawa H: Electrogenic sodium pump in rabbit atrio-ventricular node cell. Pflugers Arch 391: 261–266, 1981.PubMedGoogle Scholar
  17. 17.
    Kurachi Y, Noma A, Irisawa H: Electrogenic Na pump evidenced by injecting various Na salts into the isolated A-V node cells of rabbit heart. Pflugers Arch 392: 89–91, 1981.PubMedCrossRefGoogle Scholar
  18. 18.
    Deck KA, Kern R, Trautwein W: Voltage clamp technique in mammalian cardiac fibres. Pflugers Arch 280: 50–62, 1964.CrossRefGoogle Scholar
  19. 19.
    Carmeliet E, Vereecke J: Electrogenesis of the action potential and automaticity. In: Bern RM, Sperelakis N, Geiger SR (eds) Handbook of physiology. Sect 2: The cardiovascular system. Vol 1: The heart. Bethesda MD: American Physiological Society, 1979, pp 269–334.Google Scholar
  20. 20.
    Noma A, Irisawa H, Kokubun S, Kotake H, Nishimura M, Watanabe Y: Slow current systems in the A-V node of the rabbit heart. Nature 285: 228–229, 1980.PubMedCrossRefGoogle Scholar
  21. 21.
    Brown HF, Di Francesco D, Noble SJ: How does adrenaline accelerate the heart? Nature 280: 235–236, 1979PubMedCrossRefGoogle Scholar
  22. 22.
    Yanagihara K, Irisawa H: Inward current activated during hyperpolarization in the rabbit sinoatrial node cell. Pflugers Arch 385: 11–19, 1980.PubMedCrossRefGoogle Scholar
  23. 23.
    Maylie J, Morad M, Weiss J: A study of pace-maker potential in rabbit sino-atrial node: measurement of potassium activity under voltage-clamp conditions. J Physiol (Lond) 311: 161–178, 1981.Google Scholar
  24. 24.
    Mendez C, Moe GK: Atrioventricular transmission. In: De Mello WC (ed) Electrical phenomena in the heart. New York: Academic, 1972, pp 263–291.Google Scholar
  25. 25.
    Wit AL, Cranefield PF: Effect of verapamil on the sinoatrial and atrioventricular nodes of the rabbit and the mechanism by which it arrests reentrant atrioventricular nodal tachycardia. Circ Res 35: 413–425, 1974.PubMedCrossRefGoogle Scholar
  26. 26.
    Ponce Zumino AZ, Parisii IM, De Ceretti ERP: Effect of ischemia and low sodium medium on atrioventricular conduction. Am J Physiol 218: 1489–1494, 1970.Google Scholar
  27. 27.
    De Ceretti E, Ruiz P, Ponce Zumino A, Parissi IM: Resolution of two components in the upstroke of the action potential in atrioventricular fibers of the rabbit heart. Can J Physiol Pharmacol 49: 642–648, 1971.CrossRefGoogle Scholar
  28. 28.
    Irisawa H: Ionic currents underlying spontaneous rhythm of the cardiac primary pacemaker cells. In: Bonke FIM (ed) The sinus node. The Hague: Martinus Nijhoff, 1980, pp 368–375.Google Scholar
  29. 29.
    Kreitner D: Effects of polarization and inhibitors of ionic conductances on the action potentials of nodal and perinodal fibers in rabbit sinoatrial node. In: Bonke FIM (ed) The sinus node. The Hague: Martinus Nijhoff, 1980, pp 270–278.Google Scholar
  30. 30.
    Kokubun S, Nishimura M, Noma A, Irisawa H: The spontaneous action potential of rabbit atrioventricular node cells. Jpn J Physiol 30: 529–540, 1980.PubMedCrossRefGoogle Scholar
  31. 31.
    Wiggins JR, Cranefield PF: The effect of membrane potential and electrical activity of adding sodium to sodium-depleted cardiac Purkinje fibers. J Gen Physiol 64: 473–493, 1974.PubMedCrossRefGoogle Scholar
  32. 32.
    Morad M, Kurachi Y: Cs and Ba block the inward rectifier K channel from the outside site in single isolated ventricular cells. 1982 (in preparation).Google Scholar
  33. 33.
    Cleemann L, Morad M: Potassium currents in frog ventricular muscle: evidence from voltage clamp currents and extracellular K accumulation. J Physiol (Lond) 283: 113–143, 1979.Google Scholar
  34. 34.
    Standen NB, Stanfield PR: A potential-and time-dependent blockade of inward rectification in frog skeletal muscle fibres by barium and strontium ions. J Physiol (Lond) 280: 169–191, 1978.Google Scholar
  35. 35.
    Taniguchi J, Kokubun S, Noma A, Irisawa H: Spontaneously active cells isolated from the sino-atrial and atrio-ventricular nodes of the rabbit heart. Jpn J Physiol 31: 547–558, 1981.PubMedCrossRefGoogle Scholar
  36. 36.
    Cranefield P, Hoffman B, Paes de Carvalho A: Effects of acetylcholine on single fibers of the atrioventricular node. Circ Res 7: 19–23, 1959.PubMedCrossRefGoogle Scholar
  37. 37.
    Cranefield PF: The conduction of the cardiac impulse: the slow response and cardiac arrhythmias. Mount Kisco NY: Futura, 1975.Google Scholar
  38. 38.
    Hoffman, BF: Neural influences on cardiac electrical activity and rhythm. In: Randall WC (ed) The neural regulation of the heart. New York: Oxford University, 1977, pp 291–312.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1984

Authors and Affiliations

  • H. Irisawa
  • A. Noma
  • S. Kokubun
  • Y. Kurachi

There are no affiliations available

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