Mechanical Properties, Contractile Proteins, and Regulation of Contraction of Vascular Smooth Muscle

  • Steven P. Driska
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 34)


An understanding of vascular smooth muscle contraction is important to cardiologists and cardiac researchers because ultimately vascular smooth muscle determines both the amount of work the heart must do (by altering total peripheral resistance) and the amount of oxygen and substrates available to do it (by regulating coronary perfusion). With this relationship in mind this chapter presents a description of our present knowledge of the contractile process in vascular smooth muscle based on biochemical, biophysical, physiologic, and mechanical studies. Since other chapters in this book cover the ultrastructure, electrophysiology, and metabolism and energetics, these subjects will not be covered in any detail, and will serve to delimit the boundaries of this chapter.


Smooth Muscle Vascular Smooth Muscle Myosin Light Chain Thin Filament Thick Filament 
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© Springer Science+Business Media Dordrecht 1984

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  • Steven P. Driska

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