Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle

  • G. Droogmans
  • R. Casteels
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 34)


The contractile response of smooth muscle cells is triggered by an increase of the free cytoplasmic concentration of calcium ions. In skinned smooth muscle fibers, i.e., tissues from which the cell membrane has been chemically removed by detergent treatment, the threshold Ca concentration for initiating contraction amounts to approximately 10-7 M, and full activation of the contractile proteins occurs at about 10-5 M calcium {1–3}.


Smooth Muscle Cell Vascular Smooth Muscle Rabbit Aorta Smooth Muscle Preparation Excitatory Junction Potential 
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© Springer Science+Business Media Dordrecht 1984

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  • G. Droogmans
  • R. Casteels

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