The Pathogenesis of Coronary Atherosclerosis

  • S. David Gertz
  • Adi Kurgan
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 34)


In the United States between 1974 and 1977, 52% of all causes of death were attributed to cardiovascular diseases {1}. Ischemic heart diseases accounted for 65% of all cardiovascular diseases and were responsible for every third death (34%) in the USA during this period. The purported increase in incidence of ischemic heart disease in civilized communities during the first two-thirds of this century has been attributed variously to the decline and/or extinction of infectious diseases, to a “less than optimal adaptation to changing patterns of life style”, and to advances in diagnostic techniques. Although the mortality rate for ischemic heart disease in the USA declined significantly (21%) during the period 1968–1976 {2, 3}, its incidence has not, and this entity remains the cause of more deaths in the USA than any other disease.


Smooth Muscle Cell Arterial Wall Coronary Atherosclerosis High Density Lipoprotein Smooth Muscle Cell Proliferation 
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© Springer Science+Business Media Dordrecht 1984

Authors and Affiliations

  • S. David Gertz
  • Adi Kurgan

There are no affiliations available

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