Abstract
The mammalian heart is characterized by a vascular supply which is truly prodigious. It is curious that, of the many studies addressed to the heart, few have been directly concerned with ultrastructure of the medial or periendothelial cells of myocardial blood vessels. The term vascular smooth muscle cells comes most readily to mind when one is describing such cells, but it has become apparent that less highly developed cells occupy the walls of the heart’s microvessels. Such cells, which include entities known as primitive smooth muscle cells and pericytes, are the positional and—perhaps—the functional equivalents of the definitive smooth muscle cells of the larger myocardial blood vessels. This chapter describes the structure of true vascular smooth muscle cells (VSMC), and considers, in addition, the spectrum of periendothelial cells within the vasculature of the heart.
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References
Boucek RJ, Takashita R, Fojaco R: Relation between microanatomy and functional properties of the coronary arteries (dog). Anat Rec 147: 199–207, 1963.
Forbes MS: Ultrastructure of vascular smooth-muscle cells in mammalian heart. In: Kalsner S (ed) The coronary artery. London: Croom-Helm, 1982, pp 3–58.
Rhodin JAG: Architecture of the vessel wall. In: Bohr DF, Somlyo AP, Sparks HV Jr (eds) Handbook of physiology. Sect 2: The cardiovascular system. Vol 2: Vascular smooth Muscle. Bethesda MD: American Physiological Society, 1980, pp 1–32.
Uehara Y, Suyama K: Visualization of the adventitial aspect of the vascular smooth muscle cells under the scanning electron microscope. J Electron Microscopy 27: 157–159, 1978.
Murakami M, Sugita A, Shimada T, Nakamura K: Surface view of pericytes on the retinal capillary in rabbits revealed by scanning electron microscopy. Arch Histol Jpn 42: 287–303, 1979.
Mazanet R, Franzini-Armstrong C: Scanning electron microscopy of pericytes in rat red muscle. Microvasc Res 23: 361–369, 1982.
Somlyo AP, Garfield RE, Chacko S, Somlyo AV: Golgi organelle response to the antibiotic X537A. J Cell Biol 66: 425–443, 1975.
Eriksson A, Thornell L-E: Intermediate (skeletin) filaments in heart Purkinje fibers: a correlative morphological and biochemical identification with evidence of a cytoskeleton function. J Cell Biol 80: 231–247, 1979.
Goldman RD: The role of three cytoplasmic fibers in BHK-21 cell motility. I. Microtubules and the effects of colchicine. J Cell Biol 51: 752–762, 1971.
Forbes MS, Dent JN: Filaments and microtubules in the gonadotrophic cell of the lizard, Anolis tarolinensis. J Morphol 143: 409–434, 1974.
Cooke P: A filamentous cytoskeleton in vertebrate smooth muscle fibers. J Cell Biol 68: 539–556, 1976.
Murphy RA: Mechanics of vascular smooth muscle. In: Bohr DF, Somlyo AP, Sparks HV Jr (eds) Handbook of physiology. Sect 2: The cardiovascular system. Vol 2: Vascular smooth muscle. Bethesda MD: American Physiological Society, 1980, pp 325–352.
Somlyo AV: Ultrastructure of vascular smooth muscle. In: Bohr DF, Somlyo AP, Sparks HV Jr (eds) Handbook of physiology. Sect 2: The cardiovascular system. Vol 2: Vascular smooth muscle. Bethesda MD: American Physiological Society, 1980, pp 33–68.
Forbes MS, Sperelakis N: Structures located at the level of the Z bands in mouse ventricular myocardial cells. Tissue CA 12: 467–489, 1980.
Forbes MS, Sperelakis N: Ultrastructure of mammalian cardiac muscle. In: Sperelakis N (ed) Physiology and pathophysiology of the heart. Boston: Martinus Nijhoff, 1984, pp. 3–42.
Gabella G: Inpocketings of the cell membrane (caveolae) in the rat myocardium. J Ultrastruct Res 65: 135–147, 1978.
Masson-Pévet M, Gros D, Besselsen E: The caveolae in rabbit sinus node and atrium. Cell Tissue Res 208: 183–196, 1980.
Levin KR, Page E: Quantitative studies on plasma-lemma’ folds and caveolae of rabbit ventricular myocardial cells. Circ Res 46: 244–255, 1980.
Forbes MS, Rennels ML, Nelson E: Caveolar systems and sarcoplasmic reticulum in coronary smooth muscle cells of the mouse. J Ultrastruct Res 67: 325–339, 1979.
Forbes MS, Sperelakis N: The membrane systems and cytoskeletal elements of mammalian myocardial cells. In: Shay JW, Dowben RM (eds) Cell and muscle motility, vol 3. New York: Plenum, 1983, pp 89–155.
Somlyo AP, Devine CE, Somlyo AV, North SR: Sarcoplasmic reticulum and the temperature-dependent contraction of smooth muscle in calcium-free solutions. J Cell Biol 51: 722–741, 1971.
Somlyo AV, Somlyo AP: Strontium accumulation by sarcoplasmic reticulum and mitochondria in vascular smooth muscle. Science 174: 955–958, 1971.
Somlyo AP, Devine CE, Somlyo AV: Sarcoplasmic reticulum, mitochondria and filament organization in vascular smooth muscle. In: Betz E (ed) Vascular smooth muscle. Berlin, Springer, 1979, pp 119–121.
Devine CE, Somlyo AV, Somlyo AP: Sarcoplasmic reticulum and mitochondria as cation accumulation sites in smooth muscle. Philos Trans R Soc Lond [B] 265: 17–23, 1973.
Popescu LM, Diculescu I: Calcium in smooth muscle sarcoplasmic reticulum in situ: conventional and X-ray analytical electron microscopy. J Cell Biol 32: 911–919, 1975.
Forbes MS, Sperelakis N: Bridging junctional processes in couplings of skeletal, cardiac, and smooth muscle. Muscle Nerve 5: 674–681, 1982.
Somlyo AV: Bridging structures spanning the junctional gap at the triad of skeletal muscle. J Cell Biol 80: 743–750, 1979.
Joris I, Majno G: Cellular breakdown within the arterial wall: an ultrastructural study of the coronary artery in young and aging rats. Virchows Arch [Pathol Anat) 364: 111–127, 1974.
Franklin KJ: The physiology and pharmacology of veins. Physiol Rev 8: 346–364, 1928.
Forbes MS, Rennels ML, Nelson E: Ultrastructure of pericytes in mouse heart. Am J Anat 149: 71–92, 1977.
Rouget C: Mémoire sur le dévelopment, la structure et les propriétés physiologiques des capillaires sanguins et lymphatiques. Arch Physiol Norm Pathol 5: 603–663, 1873.
Zimmerman KW: Der feinere Bau der Blutcapillaren. Z. Anat Entwicklungsgesch 68: 3–109.
Vimtrup BJ: Beiträge zur Anatomie der Kapillaren. I. Ueber kontraktile Elemente in der Gafässwand der Blutkapillaren. Z Gesamte Anat 65: 150–182, 1922.
Krogh A: The anatomy and physiology of capillaries. New Haven: Yale University, 1929.
Majno G: The ultrastructure of the vascular membrane. In: Hamilton WF, Dow P (eds) Handbook of physiology. Circulation. Washington DC: American Physiological Society, 1965, pp 2293–2375.
Zweifach BW: Microcirculation. Annu Rev Physiol 35: 117–150, 1973.
Forbes MS, Rennels ML, Nelson E: Innervation of myocardial microcirculation: terminal autonomic axons associated with capillaries and postcapillary venules in mouse heart. Am J Anat 149: 71–92, 1977.
Rennels ML, Nelson E: Capillary innervation in the mammalian central nervous system: an electron microscopic demonstration. Am J Anat 144: 233–241, 1975.
Tilton RG, Kilo C, Williamson JR: Pericyte—endothelial relationships in cardiac and skeletal muscle capillaries. Microvasc Res 18: 325–335, 1979.
Tilton RG, Kilo C, Williamson JR, Murch DW: Differences in pericyte contractile function in rat cardiac and skeletal muscle microvasculatures. Micro-vase Res 18: 336–352, 1979.
Wallow IH, Burnside B: Actin filaments in retinal pericytes and endothelial cells. Invest Ophthalmol Vis Sci 19: 1433–1441, 1980.
Rhodin JAG: Ultrastructure of mammalian venous capillaries, venules, and small collecting veins. J UItrastruct Res 25: 452–500, 1968.
Le Beux YJ, Willemot J: Actin-and myosin-like filaments in rat brain pericytes. Anat Rec 190: 811–826, 1978.
Panner BJ, Honig CR: Filament ultrastructure and organization in vertebrate smooth muscle. J Cell Biol 35: 303–321, 1967.
Yamauchi A: Ultrastructure of the innervation of the mammalian heart. In: Challice CE, Vir£gh S (eds) New York: Academic 1973, pp 127–178.
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Forbes, M.S. (1984). Vascular Smooth Muscle Cells and Other Periendothelial Cells of Mammalian Heart. In: Sperelakis, N. (eds) Physiology and Pathophysiology of the Heart. Developments in Cardiovascular Medicine, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1171-4_32
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DOI: https://doi.org/10.1007/978-1-4757-1171-4_32
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