Hormonal Effects on Cardiac Performance

  • Eugene Morkin
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 34)


Alterations in cardiac function have been described in a number of experimental and clinical disorders of the endocrine system. For the most part, however, the mechanisms of these effects has been obscure. New insight into the problem has been provided by recognition that thyroid hormone regulates ventricular myosin isoenzyme composition {1, 2}. Now the increase in cardiac mechanical performance and myosin ATPase in the presence of excess thyroid hormone can be explained, at least in part, by increased synthesis of a myosin isoenzyme with high ATPase activity, which normally represents only a minor component of the total ventricular myosin. A similar change in myosin isoenzyme composition has been found in thyroid-deficient rats treated with triiodothyronine (T3) {3, 4}. In addition, the existence of ventricular myosin isoenzymes and the control of their expression by thyroid hormone and other factors may provide explanations for some otherwise perplexing reports of changes in myosin ATPase activity in various animal models of endocrine disorders.


Thyroid Hormone ATPase Activity Cardiac Performance Myosin Head Cardiac Myosin 
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© Springer Science+Business Media Dordrecht 1984

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  • Eugene Morkin

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