Developmental Changes in Membrane Electrical Properties of the Heart

  • Nicholas Sperelakis
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 34)


Important physiologic, electrophysiologic, pharmacologic, biochemical, and ultrastructural changes occur during the embryonic development of avian and mammalian hearts. For example, striking changes occur in the electrical properties of ventricular myocardial cells during embryonic development of chick heart. In many mammalian hearts, some of the changes extend into the early postnatal period. These changes affect and determine the functional behavior and properties of the heart at each stage of development and differentiation. Therefore, it is the purpose of this chapter to review and summarize many of these changes in properties. The attention of the reader will be called to a number of recent review articles that summarize these properties, as well as go into greater detail.


cAMP Level Heart Cell Embryonic Chick Embryonic Heart Ventricular Cell 
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  • Nicholas Sperelakis

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