Calcium and the Injured Cardiac Myocyte
Injured cardiac myocytes accumulate Ca2+. It does not seem to matter whether the injury is due to reperfusion after prolonged periods of normothermic ischemia [1, 2], sustained hypoxia , a naturally occurring cardiomyopathy, or the reintroduction of Ca2+ after only a few minutes of Ca2+-free perfusion [4–6], the end result is the same—that is, the cells become overloaded with Ca2+. The primary aim of this chapter is to establish why the injured myocytes accumulate Ca2+, and then to define the route by which this Ca2+ enters. Finally we will consider the consequences of the resultant Ca2+ overloading.
KeywordsIntercalate Disc Ischemic Episode High Energy Phosphate Massive Influx Passive Permeability
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- 2.Nayler WG: The role of calcium in the ischemic myocardium. Am J Pathol 102: 126–134, 1981.Google Scholar
- 7.Nayler WG: Protection of the myocardium against post ischemic reperfusion damage: the combined effect of hypothermia and nifedipine. J Thorac Cardiovasc Surg, 1982 (in press).Google Scholar
- 19.Jennings RB, Reimer KA, Hill ML, Mayer SE: Total ischemia in dog hearts, in vivo. 1. Comparison of high energy phosphate production, utilization, and depletion, and of adenine nucleotide catabolism in total ischemia in vivo vs. severe ischemia in vivo. Circ Res 49: 892–900, 1981.PubMedCrossRefGoogle Scholar
- 24.La Noue KF, Watts JA, Koch CD: Adenine nucleotide transport during cardiac ischemia. Am J Physiol 241: H663 - H671, 1981.Google Scholar
- 25.Dunnett J, Nayler WG: Effect of pH on calcium accumulation and release of isolated fragments of cardiac and skeletal muscle sarcoplasmic reticulum. Biochim Biophys Acta 198: 434–438, 1979.Google Scholar
- 29.Locke FS, Rosenheim O: Contributions to the physiology of the isolated heart: the consumption of dextrose by mammalian cardiac muscle. J Physiol (Lond) 36: 205–220, 1907.Google Scholar
- 35.Nayler WG: Cobalt, manganese and the calcium paradox. J Mol Cell Cardiol (Suppl 2 ) 14: 11, 1982.Google Scholar
- 37.Muir AR: A calcium-induced contracture of cardiac muscle cells. J Anat 102: 148–149, 1968.Google Scholar
- 40.Winegrad S, Robinson TF: Force generation among cells in the relaxing heart. Eur J Cardiol (Suppl) 7: 63–70, 1978.Google Scholar
- 44.Krishtal OA, Pidoplichko VI, Shaknovalov Yu A: Conductance of the calcium channel in the membrane of snail neurones. J Physiol 310: 410–434, 1981.Google Scholar