Abstract
Pluripotential hormone-secreting cells belonging to the APUD cell system (see p. 132) are distributed throughout the human foregut and its endocrine derivatives [75]. Pancreatic islet cell tumors arise from this system and are capable of secreting virtually any of the known polypeptide hormones.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Alfidi RJ, Bhyun DS, Crile G, Jr, et al: Arteriography and hypoglycemia. Surg Gynecol Obstet 133: 447, 1971.
Amberg JR, Ellison EH, Wilson SD, et al: Roentgenographic observations in the Zollinger-Ellison syndrome. JAMA 190: 185, 1964.
Aoyagi T, Summerskill WHJ: Gastric secretion with ulcerogenic islet cell tumor: Importance of basal acid output. Arch Intern Med 117: 667, 1966.
AvRuskin TW, Coran AG, Crigler JF, Jr: Insulin and growth hormone regulation in organic hyperinsulinism. Surg Gynecol Obstet 133: 1, 1971.
Ballard HS, Frame B, Hartsock RJ: Familial multiple endocrine adenoma peptic ulcer complex. Medicine 43: 481, 1964.
Barbezat GO, Grossman Ml: Intestinal secretion: Stimulation by peptides. Science 174: 422, 1971.
Baruh S, Sherman K, Kolodny HD, et al: Fasting hypoglycemia. Med Clin North Am 57: 1441, 1973.
Bell WE, Samaan NA, Longnecker DS: Hypoglycemia due to organic hyperinsulinism in infancy. Arch Neurol 23: 330, 1970.
Berson SA, Yalow RS, Bauman A, et al: Insulin 1311 metabolism in human subjects: Demonstration of insulin binding globulin in the circulation of isulin treated subjects. J Clin Invest 35: 170, 1956.
Berson SA, Yalow RS: Nature of immunoreactive gastrin extracted from tissues of gastrointestinal tract. Gastroenterology 60: 215, 1971.
Bloom SR, Polak JM, Pearse AGE: Vasoactive intestinal hormone and watery diarrhea syndrome. Lancet 2: 14, 1973.
Bonfils S, Bader JP: The diagnosis of Zollinger-Ellison syndrome with special reference to the multiple endocrine adenomas, in Progress in Gastroenterology, Vol. 2 ( GB Jersey Glass, editor). Grune and Stratton, Inc, New York, 1970, p. 332.
Bradley EL, III, Galambos JT: Failure of a secretin feedback loop in the ZollingerEllison syndrome? The “gastric factor” revisited. Am J Dig Dis 17: 939, 1972.
Briedahl HD, Priestley JT, Rynearson EH: Hyperinsulinism; surgical aspects and results. Ann Surg 142: 698, 1955.
Broder LE, Carter SK: Pancreatic islet cell carcinoma. Ann Intern Med 79: 108, 1973.
Cameron AJ, Hoffman HN: Zollinger-Ellison syndrome. Mayo Clin Proc 49: 44, 1974.
Cate11 RB, Warren KW: Surgery of the Pancreas. WB Saunders, Philadelphia, 1954.
Chandalia HB, Boshell BR: Hypoglycemia associated with extrapancreatic tumors. Arch Intern Med 129: 447, 1972.
Chaudhuri TK, Chaudhuri TK, Shirazi SS, et al: Radioisotopic scan-a possible aid in differentiating retained gastric antrum from Zollinger-Ellison syndrome in patients with recurrent peptic ulcer. Gastroenterology 65: 697, 1973.
Conn JW, Seltzer HS; Spontaneous hypoglycemia. Am J Med 19: 460, 1955.
Couropmitree C, Freinkel N, Nagel TC, et al: Plasma C-peptide and diagnosis of factitious hyperinsulinism. Ann Intern Med 88: 201, 1975.
Cowley DJ, Dymock IW, Boyes BE, et al: Zollinger-Ellison syndrome type 1: Clinical and pathological correlations in a case. Gut 14: 25, 1973.
Creutzfeldt W, Arnold R, Creutzfeldt C, et al: Pathomorphological, biochemical, and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome). Hum Pathol (in press).
Davenport HW: Physiology of the Digestive Tract: An Introductory Text, Third Edition. Yearbook Medical Publishers, Chicago, 1971.
Dent RI, James JH, Wang C-A, et al. Hyperparathyroidism: gastric acid secretion and gastrin. Ann Surg 176: 360, 1972.
dePeyster FA: Planning the appropriate operations for islet cell tumors of the pancreas. Surg Clin North Am 50: 133, 1970.
Elias E, Bloom SR, Welbourne RB, et al: Pancreatic cholera due to production of gastric inhibitory polypeptide. Lancet 2: 791, 1972.
Ellison EH, Wilson SD: Zollinger-Ellison syndrome: Reappraisal and evaluation of 260 registered cases. Ann Surg 160: 512, 1964.
Epstein HY, Abrams RM, Beranbaum ER, et al: Angiographic localization of insulinomas: High reported success rate and two additional cases. Ann Surg 169: 349, 1969.
Fajans SS, Conn JW: An intravenous tolbutamide test as an adjunct in the diagnosis of functioning pancreatic islet cell adenomas. J Lab Clin Med 54: 811, 1959.
Fajans SS, Floyd JC, Jr: Hypoglycemia: How to manage a complex disease. Mod Med 41: 24, 1973.
Fajans SS, Schneider JM, Schteingart DE, et al: Diagnostic value of tolbutamide in hypoglycemic states. J Clin Endocrinol 21: 371, 1961.
Ferris DO, Molnar GD, Schnelle N, et al: Recent advances in management of functioning islet cell tumor. Arch Surg 104: 443, 1972.
Filipi CJ, Higgins GA: Diagnosis and management of insulinoma. Am J Surg 125: 231, 1973.
Fonkalsrud EW, Dilley RB, Longmire WP, et al: Insulin secreting tumors of the pancreas. Ann Surg 159: 730, 1964.
Fox PS, Hofmann JW, DeCosse JJ, et al: The influence of total gastrectomy on survival in malignant Zollinger-Ellison tumors. Ann Surg (in press).
Fox PS, Hofmann JW, Wilson SD, et al: Surgical management of the Zollinger Ellison syndrome. Surg Clin North Am 54: 395, 1974.
Friesen SR: Effect of total gastrectomy on the Zollinger-Ellison tumor: observations by second-look procedures. Surgery 62: 609, 1967.
Friesen SR: The endocrine pancreas, in Manual of Preoperative and Postoperative Care ( JM Kinney, RH Egdahl, GD Zuidema, editors). WB Saunders Co, Philadelphia, 1971, p. 514.
Friesen SR, Bolinger RE, Pearse AGE, et al: Serum gastrin levels in malignant Zollinger-Ellison syndrome after total gastrectomy and hypophysectomy. Ann Surg 172: 504, 1970.
Fry WJ, Child CG: Ninety-five percent distal pancreatectomy for chronic pancreatitis. Ann Surg 162: 543, 1965.
Fulton RE, Sheedy PF, III, Mcllraith DC, et al: Preoperative angiographic localization of insulin-producing tumors of the pancreas. Am J Roentgenol Rad Ther Nucl Med 123: 367, 1975.
Ganguli PC, Pearse AGE, Polak JB, et al: Antral-gastrin-cell hyperplasia in peptic ulcer disease. Lancet 1: 583, 1974.
Giacobazzi P, Passaro E, Jr.: Preoperative angiography in the Zollinger-Ellison syndrome. Am J Surg 126: 74, 1973.
Go VLW, Poley JR, Hoffman AF et al: Disturbances in fat digestion induced by acidic jejunal pH due to gastric hypersecretion in man. Gastroenterology 55: 705, 1968.
Graham RR: quoted in G Howland, WR Campbell, EJ Maltby, et al: Dysinsulism: Convulsions and coma due to islet-cell tumor of the pancreas with operation and cure. JAMA 93:674, 1929.
Gray RK, Rosch J, Grollman JH, Jr: Arteriography in the diagnosis of islet-cell tumors. Radiology 97: 39, 1970.
Greider MH, Elliott DW, Zollinger RM: An electron microscopic study of islet cell adenomas. JAMA 186: 120, 1963.
Greider MH, McGuigan JE: Cellular localization of gastrin in the human pancreas. Diabetes 20: 389, 1971.
Hansky J: Antral-gastrin-cell hyperplasia in peptic ulcer disease. Lancet 1: 1344, 1974.
Harrison TS, Child CG, Fry WJ, et al: Current surgical management of functioning islet cell tumors of the pancreas. Ann Surg 178: 485, 1973.
Isenberg JI, Csendes A, Walsh JH: Resting and pentagastrin-stimulated gastroesophageal sphincter pressure in patients with Zollinger-Ellison syndrome. Gastroenterology 61: 655, 1971.
Isenberg JI, Walsh JH, Grossman MI: Zollinger-Ellison syndrome. Gastroenterology 65:140, 1973.
Isenberg JI, Walsh JH, Passaro E, et al: Unusual effect of secretin on serum gastrin, serum calcium, and gastric secretion in a patient with suspected Zollinger-Ellison syndrome. Gastroenterology 62: 626, 1972.
Jaffe BM, Peskin GW, Kaplan EL: Serum levels of parathyroid hormone in the Zollinger-Ellison syndrome. Surgery 74: 621, 1973.
Keaveny TV, Tawes R, Belzer FO: A new method for intraoperative identification of insulinomas. Br J Surg 58: 233, 1971.
Korman MG, Scott DH, Hansky J, et al: Hypergastrinaemia due to an excluded gastric antrum: A proposed method of differentiation from the Zollinger-Ellison syndrome. Aust NZ J Med 3: 266, 1972.
Korobkin MT, Palubinskas AJ, Glickman MG: Pitfalls in arteriography of islet cell tumors of the pancreas. Radiology 100:319, 1971.
Koutras P, White RR: Insulin-secreting tumors of the pancreas. Surg Clin North Am 52: 299, 1972.
Kraft AR, Tompkins RK, Zollinger RM: Recognition and management of the diarrheal syndrome caused by nonbeta islet cell tumors of the pancreas. Am J Surg 119:163, 1970.
Lacy PE, Greider MH: Ultrastructural organization of mammalian pancreatic islets, in Handbook of Physiology,Section 7, Endocrinology,Vol. 1. American Physiological Society, Washington DC, 1972, p: 77.
Laroche GP, Ferris DO, Priestley JT, et al: Hyperinsulinism. Arch Surg 96: 763, 1968.
Lazaus SS, Volk BW: The Pancreas in Human and Experimental Diabetes. Grune and Stratton, New York, 1962.
Maingot R: Abdominal Operations, Fifth Edition. New York, Appleton-CenturyCrofts, Inc., New York, 1969, p. 452.
Markowitz AM, Slanetz CA, Jr, Frantz VK: Functioning islet cell tumors of the pancreas: 25-year follow-up. Ann Surg 154: 877, 1961.
Marks IN, Bank J, Louw JH: Islet cell tumor of the pancreas with reversible watery diarrhea and achlorhydria. Gastroenterology 52: 695, 1967.
Marks V, Samols E: Insulinoma: Natural history and diagnosis. Clin Gastroenterol 3:559, 1974.
McGuigan JE, Colwell JA, Franklin J: Effect of parathyroidectomy on hypercalcemic hypersecretory peptic ulcer disease. Gastroenterology 66: 269, 1974.
Moss NH, Rhoads JE: Hyperinsulinism and islet cell tumors of the pancreas, in Surgical Diseases of the Pancreas ( JM Howard, GL Jordon Jr., editors). JB Lippincott, Philadelphia, 1960, Chapter 21.
Murray-Lyon IM, Eddleston ALWF, Williams R, et al: Treatment of multiplehormone-producing malignant islet-cell tumors with streptozotocin. Lancet 2: 895, 1968.
Nardi GL: Insulinomas, in Advances in Surgery, Vol. 5. Yearbook Medical Publishers, Inc., Chicago, 1971, p. 103.
Oberhelman HA: Excisional therapy for ulcerogenic tumors of the duodenum: long-term results. Arch Surg 104:447, 1972.
O’Neal LW, Kipnis DM, Luce SA, et al: Secretion of various endocrine substances by ACTH-secreting tumors: Gastrin, melanotropin, serotonin, parathormone, vasopressin, glucagon. Cancer 21:1219 1968.
Palumbo PJ, Molnar GD, Taylor WF, et al: Insulin antibody binding in diabetes mellitus and factitious hypoglycemia. Mayo Clin Proc 44: 725, 1969.
Pearse AGE, Polak J: Neural crest origin of the endocrine polypeptide (APUD) cells of the gastrointestinal tract and pancreas Gut 12: 783, 1971.
Polak JM, Stagg B, Pearse AGE: Two types of Zollinger-Ellison syndrome: Immunofluorescent, cytochemical, and ultrastructural studies of the antral and pancreatic gastric cells in different clinical states. Gut 13: 501, 1972.
Porter MR, Frantz VK: Tumors associated with hypoglycemia: Pancreatic and extrapancreatic. Am J Med 944: 21, 1956.
Priest WM, Alexander MK: Islet-cell tumor of the pancreas with peptic ulceration, diarrhea, and hypokalemia. Lancet 2: 1145, 1957.
Robins SL: The pancreas, in Pathology. WB Saunders, Philadelphia, 1967, p. 963.
Rynearson EH: Hyperinsulinism among malingerers. Med Clin North Am 31: 477, 1947.
Sanzenbacher LJ, King DR, Zollinger RM: Prognostic implications of calcium-mediated gastrin levels in the ulcerogenic syndrome. Am J Surg 125: 116, 1973.
Sanzenbacher LJ, Mekhjian HS, King DR, et al: Studies on the potential role of secretin in the islet cell tumor diarrhogenic syndrome. Ann Surg 176: 394, 1972.
Schein P, Kahn R, Gorden P, et al: Streptozotocin for malignant insulinomas and carcinoid tumors: Report of eight cases and a review of the literature. Arch Intern Med 132: 555, 1973.
Schnelle N, Molnar GD, Ferris DO, et al: Circulating glucose and insulin in surgery for insulinomas. JAMA 217: 1072, 1971.
Service FJ, Palumbo PJ: Facticial hypoglycemia: Three cases diagnosed on the basis of insulin antibodies. Arch Intern Med 134: 336, 1974.
Shatney CH, Grage TB: Diagnostic and surgical aspects of insulinoma. Am J Surg 127: 174, 1974.
Sherman BM, Pek S, Fajans SS, et al: Plasma proinsulin in patients with functioning islet cell tumors. J Clin Endocrinol Metab 35: 271, 1972.
Silen W: Pancreas, in Principles of Surgery ( SI Schwartz, editor). McGraw Hill Book Co, New York, 1969, p. 1112.
Sircus W: Peptide-secreting tumors and peptic ulcer. Clin Gastroenterol 2: 447, 1973.
Spiro EM: Clinical Gastroenterology. The MacMillan Co, Toronto, 1970.
Stadil F, Rehfeld JF, Thaysen EH: Gastric juice as gastric-releasing factor in the Zollinger-Ellison syndrome. Lancet 2: 102, 1971.
Stefanini P, Carboni M, Patrassi N, et al: Beta-islet cell tumors of the pancreas: Results of a study on 1,067 cases. Surgery 75: 597, 1974.
Stefanini P, Carboni M, Patrassi N: Surgical treatment and prognosis of insulinoma. Clin Gastroenterol 3: 697, 1974.
Thompson JC, Reeder DD, Bunchman H H: Clinical role of serum gastrin measurements in the Zollinger-Ellison syndrome. Am J Surg 124: 250, 1972.
Thompson S, Welch KJ: Surgery of the pancreas, in Pediatric Surgery ( CD Benson, MM Mustard, WH Snyder Jr, et al, editors). Yearbook Medical Publishers, Inc, 1962, p. 629.
Turbey WJ, Passaro EW, Jr: Hyperparathyroidism in the Zollinger-Ellison syndrome. Arch Surg 105: 62, 1972.
Turner RC, Johnson PC: Suppression of insulin release by fish-insulin-induced hypoglycemia with reference to the diagnosis of insulinomas. Lancet Vol. 1: 1483, 1973.
Verner JV, Morrison AB: Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia. Am J Med 29: 529, 1958.
Walsh JH, Grossman MI: Gastrin. IV Engl J Med 292: 1377, 1975.
Warren KW: Current management of benign and malignant pancreatic tumors. Am Surg 20: 1070, 1954.
Wermer P: Genetic aspects of adenomatosis of endocrine glands. Am J Med 16: 363, 1954.
Whipple AO: Hyperinsulinism in relation to pancreatic tumors. Surgery 16: 289, 1944.
Whipple AO, Frantz VK: Adenoma of islet cells with hyperinsulinism. Ann Surg 101: 1299, 1935.
Wilder RM, Allan FH, Power MH, et al: Carcinoma of the islands of the pancreas. Hyperinsulinism and hypoglycemia. JAMA 89: 348, 1927.
Wilson SD, Ellison EH: Survival in patients with the Zollinger-Ellison syndrome treated by total gastrectomy. Am J Surg 111: 787, 1966.
Winship DH: Patterns in the diagnosis of Zollinger-Ellison syndrome by analysis of gastric secretion, non-insulin-producing tumors of the pancreas, in Modern Aspects on Zollinger-Ellison Syndrome and Gastrin. (L Demling, R Ottenjann, editors). International Symposium at Erlangen, July 16–17, 1968. Georg Thieme Verlag, Stuttgart, 1969, p. 129.
Winship DH, Ellison EH: Variability of gastric secretion in patients with and without Zollinger-Ellison syndrome. Lancet 1: 1128, 1967.
Wright HK, Hersh T, Floch MH, et al: Impaired intestinal absorption in the Zollinger-Ellison syndrome independent of gastric hypersecretion. Am J Surg 119: 250, 1970.
Zollinger RM: Islet cell tumor of the pancreas and the alimentary tract. Am J Surg 129: 102, 1975.
Zollinger RM, Ellison EH: Primary hepatic ulceration of the jejunum associated with islet cell tumors of the pancreas. Ann Surg 142: 709, 1955.
Zollinger RM, Tompkins RK, Amerson JR, et al: Identification of the diarrheogenic hormone associated with nonbeta islet cell tumors of the pancreas. Ann Surg 168:502, 1968.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer Science+Business Media New York
About this chapter
Cite this chapter
Edis, A.J., Ayala, L.A., Egdahl, R.H. (1975). Surgery of the Endocrine Pancreas. In: Manual of Endocrine Surgery. Comprehensive Manuals of Surgical Specialties. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-1159-2_4
Download citation
DOI: https://doi.org/10.1007/978-1-4757-1159-2_4
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4757-1161-5
Online ISBN: 978-1-4757-1159-2
eBook Packages: Springer Book Archive