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Rocky Mountain Spotted Fever

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Abstract

Rocky Mountain spotted fever is an acute febrile illness transmitted to man by ticks infected with Rickettsia rickettsii. Usually sudden in onset, it is characterized by chills, headache, and fever lasting 2 or more weeks. A characteristic rash appears on the extremities on about the 4th febrile day and, later, on the trunk. The exanthem and other anatomical manifestations result from focal areas of endangiitis scattered throughout the body. Central nervous system manifestations of delirium and coma as well as shock and renal failure occur in the severely ill. Serum antibodies to Proteus organisms and specific rickettsial antigens appear during the 2nd and 3rd weeks of illness. Chloramphenicol and the tetracyclines are highly specific therapeutically.

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References

  1. Aikawa, J. K., Rocky Mountain Spotted Fever, Charles C Thomas, Springfield, Illinois, 1966.

    Google Scholar 

  2. Burgdorfer, W., Evaluation of the fluorescent antibody technique for the detection of Rocky Mountain spotted fever rickettsia in various tissues, Pathol. Microbiol. 24(Suppl.):27–39 (1961).

    Google Scholar 

  3. Cox, H. R., Use of yolk sac of developing chick embryo as medium for growing rickettsiae of Rocky Mountain spotted fever and typhus groups, Public Health Rep. 53:2241–2247 (1938).

    Article  Google Scholar 

  4. Cox, H. R., The spotted fever group, in: Viral and Rickettsial Diseases of Man, 3rd ed. (T. M. Rivers and F. L. Horsfall Jr., eds), pp. 828–868, Lippincott, Philadelphia, 1959.

    Google Scholar 

  5. Deshazo, R. D., Boyce, J. R., Osterman, J. V., and Stephenson, E. H., Early diagnosis of Rocky Mountain spotted fever: Use of primary monocyte culture technique, J. Am. Med. Assoc. 235:1353–1355 (1976).

    Article  CAS  Google Scholar 

  6. Dupont, H. L., Hornick, R. B., Dawkins, A. T., Heiner, G. G., Fabrikant, I. B., Wisseman, C. L., Jr., and Woodward, T. E., Rocky Mountain spotted fever: A comparative study of the active immunity induced by inactivated and viable pathogenic Rickettsia rickettsii,J. Infect. Dis. 128:340–344 (1973).

    Article  PubMed  CAS  Google Scholar 

  7. Dyer, R. E., Rumreich, A. S., and Badger, L. F., The typhus Rocky Mountain spotted fever group in the United States, J. Am. Med. Assoc. 97:589 (1931).

    Article  Google Scholar 

  8. Fuller, H. S., Biologic properties of pathogenic rickettsiae, Arch. Inst. Pasteur Tunis 36:311–338 (1959).

    Google Scholar 

  9. Hattwick, M. A., Obrien, R. J., and Hanson, B. F., Rocky Mountain spotted fever: Epidemiology of an increasing problem, Ann. Intern. Med. 84:732–739 (1976).

    PubMed  CAS  Google Scholar 

  10. Kenyon, R. H., Williams, R. G., Oster, C. N., and Pedersen, C. E., Jr., Prophylactic treatment of Rocky Mountain spotted fever, J. Clin. Microbiol. 8:102–104 (1978).

    PubMed  CAS  Google Scholar 

  11. Kohls, G. M., Vectors of rickettsial diseases, in: Rickettsial Diseases of Man (F. R. Moulton, ed.), pp. 83–96, American Association for the Advancement of Science, Washington, D.C., 1948.

    Google Scholar 

  12. Ley, H. L., Jr., Diercks, F. H., Paterson, P. Y., Smadel, J. L., Wisseman, C. L., Jr., and Traub, R., Immunization against scrub typhus. IV. Living Karp vaccine and chemoprophylaxis in volunteers, Am. J. Hyg. 56:303–312 (1952).

    PubMed  Google Scholar 

  13. McCalla, L. P., Direct transmission from man to man of the Rocky Mountain spotted (tick) fever. Med. Sentinel 16:87 (1908).

    Google Scholar 

  14. Parker, R. R., Rocky Mountain spotted fever: Results of fifteen years of prophylactic vaccination, Am. J. Trop. Med. 21:369 (1941).

    Google Scholar 

  15. Pederson, C. E., Jr., Rocky Mountain spotted fever: A disease that must be recognized, J. Am. Med. Technol. 39:190–198 (1977).

    Google Scholar 

  16. Pederson, C. E., Jr., Bagley, L. R., Kenyon, R. H., Sammons, L. S., and Burger, G. T., Demonstration of Rickettsia rickettsii in the rhesus monkey by immune fluorescence microscopy, J. Clin. Microbiol. 2:121–125 (1975).

    Google Scholar 

  17. Pincoffs, M. C., Personal communication.

    Google Scholar 

  18. Pinkerton, H., and Maxcy, K. F., Pathological study of a case of endemic typhus in Virginia with demonstration of rickettsia, Am. J. Pathol. 7:95–103 (1931).

    PubMed  CAS  Google Scholar 

  19. Price, W. H., The epidemiology of Rocky Mountain spotted fever: The characterization of strain virulence of Rickettsia rickettsii,Am. J. Hyg. 58:248–268 (1953).

    PubMed  CAS  Google Scholar 

  20. Ricketts, H. T., The study of “Rocky Mountain spotted fever” (tick fever) by means of animal inoculations, J. Am. Med. Assoc. 47:358 (1906).

    Article  Google Scholar 

  21. Ricketts, H. T., The role of the wood-tick (Dermacentor occidentalis) in Rocky Mountain spotted fever, and the susceptibility of local animals to this disease, J. Am. Med. Assoc. 49:24 (1907).

    Article  Google Scholar 

  22. Rose, H. M., Duane, R. B., and Fischell, E. E., The treatment of spotted fever with para-aminobenzoic acid, J. Am. Med. Assoc. 129:1160–1163 (1945).

    Article  PubMed  CAS  Google Scholar 

  23. Smadel, J. E., Rocky Mountain spotted fever vaccine, in: Symposium on the Spotted Fever Group, Med. Sci. Publ. No. 7 Wrair 55–61, U.S. Government Printing Office, Washington, D.C., 1960.

    Google Scholar 

  24. Smadel, J. E., and Jackson, E. B., Rickettsial infections, in: Diagnostic Procedures for Viral and Rickettsial Disease, 3rd ed., pp. 743–771, American Public Health Association, New York, 1964.

    Google Scholar 

  25. Spencer, R. R., and Parker, R. R., Rocky Mountain spotted fever: Infectivity of fasting and recently fed ticks, Public Health Rep. 38:33 (1923).

    Google Scholar 

  26. Spencer, R. R., and Parker, R. R., Studies on Rocky Mountain spotted fever: Vaccination of monkeys and man. Public Health Rep. 40:2159 (1925).

    Article  Google Scholar 

  27. Spencer, R. R., and Parker, R. R., Studies in Rocky Mountain spotted fever, National Health Service, Hygienic Library Bull. No. 154, U.S. Government Printing Office, Washington, D.C., 1930.

    Google Scholar 

  28. Tigertt, W. D., Studies in Q fever in man, in: Symposium of Q Fever, Med. Sci. Publ. Walter Reed Army Inst. Res., No. 6, pp. 39–46, U.S. Govt. Printing Office, Washington, D.C., 1959.

    Google Scholar 

  29. Wells, G. M., Woodward, T. E., Fiset, P., and Hornick, R. B., Rocky Mountain spotted fever caused by blood transfusion, J. Am. Med. Assoc. 239:2763–2765 (1978).

    Article  CAS  Google Scholar 

  30. Wilson, L. B., and Chowning, W. M., Studies in pyroplasmosis hominis (“spotted fever” or “tick fever” of the Rocky Mountains), J. Infect. Dis. 1:31 (1904).

    Article  Google Scholar 

  31. Wolbach, S. B., Studies on Rocky Mountain spotted fever, J. Med. Res. 41:1–97 (1919).

    PubMed  CAS  Google Scholar 

  32. Woodward, T. E., Rickettsial diseases in the United States, Med. Clin. North Am. 43:1507–1535 (1959).

    PubMed  CAS  Google Scholar 

  33. Woodward, T. E., and Jackson, E. B., Spotted fever rickettsiae, in: Viral and Rickettsial Infection of Man, 4th ed. (F. L. Horsfall Jr., and T. Tamm, eds.), pp. 1095–1129, Lippincott, Philadelphia, 1965.

    Google Scholar 

  34. Woodward, T. E., Pedersen, C. E., Jr., Oster, C. N., Bagley, L. R., Romberger, J., and Snyder, M. J., Prompt confirmation of Rocky Mountain spotted fever: Identification of rickettsiae in skin tissues, J. Infect. Dis. 134:293–301 (1976).

    Article  Google Scholar 

Suggested Reading

  • Harrell, G. T., Rocky Mountain spotted fever, Medicine 28:333–370 (1949).

    Article  PubMed  CAS  Google Scholar 

  • Hattwick, M. A. W., O’Brien, R. J., and Hanson, B. F., Rocky Mountain spotted fever: Epidemiology of an increasing problem, Ann. Intern. Med. 84:732–739 (1976).

    PubMed  CAS  Google Scholar 

  • Hechemy, K. E., Laboratory diagnosis of Rocky Mountain spotted fever, N. Engl. J. Med. 300:859–860 (1979).

    PubMed  CAS  Google Scholar 

  • Philip, R. N., Casperie, A., Maccormack, J. N., Sexton, D. K., Thomas, L. A., Anacker, R. L., Burgdorfer, W., and Vick, S., A comparison of serologic methods for diagnosis of Rocky Mountain spotted fever, Am. J. Epidemiol. 105:56 (1977).

    PubMed  CAS  Google Scholar 

  • Soneshine D. E., Bozeman, M. F., Williams, M. S., Masiello, S. A., Chadwick, D. P., Stocks, N. I., Lauer, D. M., and Elisberg, B. I., Epizootiology of epidemic typhus (Rickettsia prowazeki) in flying squirrels, Am. J. Trop. Med. Hyg. 27:339–349.

    Google Scholar 

  • Woodward, T. E., Section 10, The Rickettsioses, Harrison’s Principles of Internal Medicine, 9th ed., pp. 746–759, McGraw—Hill, New York, 1980.

    Google Scholar 

  • Woodward, T. E., and Jackson, E. B., Spotted fever rickettsiae, in: Viral and Rickettsial Infections of Man, 4th ed. (F. L. Horsfall Jr., and I. Tamm, eds.), pp. 1095–1129, Lippincott, Philadelphia, 1965.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA

    Theodore E. Woodward

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  1. Theodore E. Woodward
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Editors and Affiliations

  1. Yale University School of Medicine, New Haven, Connecticut, USA

    Alfred S. Evans (John Rodman Paul Professor of Epidemiology) (John Rodman Paul Professor of Epidemiology)

  2. Upstate Medical Center, State University of New York, Syracuse, New York, USA

    Harry A. Feldman

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© 1982 Springer Science+Business Media New York

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Woodward, T.E. (1982). Rocky Mountain Spotted Fever. In: Evans, A.S., Feldman, H.A. (eds) Bacterial Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1140-0_25

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  • DOI: https://doi.org/10.1007/978-1-4757-1140-0_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-1142-4

  • Online ISBN: 978-1-4757-1140-0

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