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Psychoactive Substance Use Disorders

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Book cover The Practitioner’s Guide to Psychoactive Drugs

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Abstract

The self-administration of chemical substances that alter mood or thinking has been a widespread practice for centuries. When the use of such substances deviates from societal norms or is deemed harmful to physical or mental health, substance use may merge into substance abuse and dependence.

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Selected Reading

General

  1. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 3, revised. Washington, American Psychiatric Association, 1987.

    Google Scholar 

  2. Baldessarini R. J.: Chemotherapy in Psychiatry. Cambridge, Harvard University Press, 1985.

    Google Scholar 

  3. Braude M. C.: Perinatal effects of drugs of abuse: Symposium summary. Fed Proc 46:2446–2453, 1987.

    PubMed  CAS  Google Scholar 

  4. Kozel N. J., Adams E. H.: Epidemiology of drug abuse: An overview. Science 234:970–974, 1986.

    Article  PubMed  CAS  Google Scholar 

  5. Meyer R. E. (ed): Psychopathology and Additive Disorders. New York, Guilford Press, 1986.

    Google Scholar 

  6. Mirin S. M. (ed): Substance Abuse and Psychopathology. Washington, American Psychiatric Press, 1984.

    Google Scholar 

  7. Mirin S. M., Weiss R. D., Michael J.: Psychopathology in substance abusers: Diagnosis and treatment. Am J Drug Alcohol Abuse 14:139–157, 1988.

    Article  PubMed  CAS  Google Scholar 

Opioids

  1. Bale R. N., Van Stone W. W., Kuldau J. M., et al: Therapeutic communities vs methadone maintenance. A prospective controlled study of narcotic addiction treatment: Design and one-year follow-up. Arch Gen Psychiatry 37:179–193, 1980.

    Article  PubMed  CAS  Google Scholar 

  2. Batki S. L., Sorensen J. L., Faltz B., et al: Psychiatric aspects of treatment of i. v. drug abusers with AIDS. Hosp Community Psychiatry 39:439–441, 1988.

    PubMed  CAS  Google Scholar 

  3. Charney D. S., Riordan C. E., Kleber H. D.: Clonidine and naltrexone: A safe, effective and rapid treatment of abrupt withdrawal from methadone therapy. Arch Gen Psychiatry 39:1327–1332, 1982.

    Article  PubMed  CAS  Google Scholar 

  4. Crabtree B. L. : Review of naltrexone, a long-acting opiate antagonist. Clin Pharm 3:273–280, 1984.

    PubMed  CAS  Google Scholar 

  5. Crowley T. J., Wagner J. E., Zerbe G.: Naltrexone-induced dysphoria in former opioid addicts. Am J Psychiatry 142:1081–1084, 1985.

    PubMed  CAS  Google Scholar 

  6. Cushman P.: The major medical sequelae of opioid addiction. Drug Alcohol Dep 5:239–254, 1980.

    Article  CAS  Google Scholar 

  7. Davis D. D., Templer D. I.: Neurobehavioral functioning in children exposed to narcotics in utero. Addict Behav 13:275–283, 1988.

    Article  CAS  Google Scholar 

  8. Dole V. P.: Narcotic addiction, physical dependence and relapse. N Engl J Med 286:988–992, 1972.

    Article  PubMed  CAS  Google Scholar 

  9. Dole V. P.: Implications of methadone maintenance for theories of narcotic addiction. JAMA 260:3025–3029, 1988.

    Article  PubMed  CAS  Google Scholar 

  10. Dole V. P., Nyswander M. E.: Heroin addiction-a metabolic disease. Arch Intern Med 120:19–24, 1967.

    Article  PubMed  CAS  Google Scholar 

  11. Edelin K. C., Gurganious L., Golar K.: Methadone maintenance in pregnancy: consequences to care and outcome. Obstet Gynecol 71:399–404, 1988.

    PubMed  CAS  Google Scholar 

  12. Faltz B. G.: Counseling substance abuse clients infected with human immunodeficiency virus. J Psychoactive Drugs 20:217–221, 1988.

    Article  PubMed  CAS  Google Scholar 

  13. Friedman A. S., Glickman N. W.: Residential program characteristics for completion of treatment by adolescent drug abusers. J Nerv Ment Dis 175:419–424, 1987.

    Article  PubMed  CAS  Google Scholar 

  14. Greenstein R. A., Arndt I. C., et al: Naltrexone: A clinical perspective. J Clin Psychiatry 45:25–28, 1984.

    PubMed  CAS  Google Scholar 

  15. Gritz E. R., Shiffman S. M., Jarvik M. E., McLellan A. T.: Physiological and psychological effects of methadone in man. Arch Gen Psychiatry 32:237–242, 1975.

    Article  PubMed  CAS  Google Scholar 

  16. Haastrup S., Jepsen P. W.: Eleven year follow-up of 300 young opioid addicts. Acta Psychiatr Scand 77:22–26, 1988.

    Article  PubMed  CAS  Google Scholar 

  17. Jaffe J. H.: Drug addiction and drug abuse, in Goodman L. S., Gilman A., Gilman A. G. (eds): Goodman and Gilman’s The Pharmacological Basis of Therapeutics, ed 7. New York, Macmillan, 1985, pp 532–581.

    Google Scholar 

  18. Jaffe J. H., Martin W. R.: Opioid analgesics and antagonists, in Goodman L. S., Gilman A., Gilman A. G. (eds): Goodman and Gilman’s The Pharmacological Basis of Therapeutics, ed 7. New York, Macmillan, 1985, pp 491–531.

    Google Scholar 

  19. Jasinski D. R., Pevnick J. S., Griffith J. D.: Human pharmacology and abuse potential of the analgesic buprenorphine: A potential agent for treating narcotic addiction. Arch Gen Psychiatry 35:501–514, 1978.

    Article  PubMed  CAS  Google Scholar 

  20. Kleber H. D.: Naltrexone. J Subst Abuse Treat 2:117–122, 1985.

    Article  PubMed  CAS  Google Scholar 

  21. Kleber H. D.: Treatment of narcotic addicts. Psychiatric Med 3:389–418, 1987.

    Google Scholar 

  22. Kleber H. D., Kosten T. R.: Naltrexone induction: Psychologic and pharmacologic strategies. J Clin Psychiatry 45:29–38, 1984.

    PubMed  CAS  Google Scholar 

  23. Kleber H. D., Riordan C. E., Rounsaville B.: Clonidine in outpatient detoxification from methadone maintenance. Arch Gen Psychiatry 42:391–394, 1985.

    Article  PubMed  CAS  Google Scholar 

  24. Kleber H. D., Slobetz F.: Outpatient drug-free treatment, in DuPont R. L., Goldstein A., O’Donnell J. (eds): Handbook on Drug Abuse. Washington, National Institute on Drug Abuse, 1979, pp 31–38.

    Google Scholar 

  25. Kosten T. R., Kleber H. D.: Buprenorphine detoxification from opioid dependence: A pilot study. Life Sci 42:635–641, 1988.

    Article  PubMed  CAS  Google Scholar 

  26. Kosten T. R., Kleber H. D.: Strategies to improve compliance with narcotic antagonists. Am J Drug Alcohol Abuse 11:249–266, 1984.

    Google Scholar 

  27. Kosten T. R., Rounsaville B. J.: Psychopathology in opioid addicts. Psychiatr Clin North Am 9:515–532, 1986.

    PubMed  CAS  Google Scholar 

  28. Kreek M. J.: Medical safety and side effects of methadone in tolerant individuals. JAMA 223:665–668, 1973.

    Article  PubMed  CAS  Google Scholar 

  29. Martin W. R.: Naloxone. Ann Intern Med 85:765–768, 1976.

    PubMed  CAS  Google Scholar 

  30. Mello N. K., Mendelson J. H.: Buprenorphine suppresses heroin use by heroin addicts. Science 207:657–659, 1980.

    Article  PubMed  CAS  Google Scholar 

  31. Meyer R. E., Mirin S. M.: The Heroin Stimulus: Implications for a Theory of Addiction. New York, Plenum Press, 1979.

    Google Scholar 

  32. Milby J. B.: Methadone maintenance to abstinence-how many make it? J Nerv Ment Dis 176:409–422, 1988.

    Article  PubMed  CAS  Google Scholar 

  33. Mirin S. M., Meyer R. E., McNamee H. B.: Psychopathology and mood during heroin use. Arch Gen Psychiatry 33:1503–1508, 1976.

    Article  PubMed  CAS  Google Scholar 

  34. Mirin S. M., Meyer R. E., Mendelson, J. H., et al: Opiate use and sexual function. Am J Psychiatry 137:909–915, 1980.

    PubMed  CAS  Google Scholar 

  35. National Research Council Committee on Clinical Evaluation of Narcotic Antagonists: Clinical evaluation of naltrexone treatment of opiate-dependent individuals. Arch Gen Psychiatry 35:335–340, 1978.

    Article  Google Scholar 

  36. Newman R. G.: Methadone treatment-defining and evaluating success. N Engl J Med 317:447–450, 1987.

    Article  PubMed  CAS  Google Scholar 

  37. O’Brien C. P., Testa T., O’Brien T. J., et al: Conditioned narcotic withdrawal in humans. Science 195:1000–1002, 1977.

    Article  PubMed  Google Scholar 

  38. Resnick R. B., Schuyten-Resnick E., Washton A. M.: Treatment of opioid dependence with narcotic antagonists: A review and commentary, in DuPont R. L., Goldstein A., O’Donnell J. (eds): Handbook on Drug Abuse. Washington, National Institute on Drug Abuse, 1979, pp 76–104.

    Google Scholar 

  39. Rounsaville B. J., Kosten T., Kleber H.: Success and failure at outpatient detoxification. Evaluating the process of clonidine and methadone-assisted withdrawal. J Nerv Ment Dis 173:103–110, 1985.

    Article  PubMed  CAS  Google Scholar 

  40. Rounsaville B. J., Weissman M. M., Crits-Cristoph K.: Diagnosis and symptoms of depression in opiate addicts. Course and relationship to treatment outcome. Arch Gen Psychiatry 39:151–156, 1982.

    Article  PubMed  CAS  Google Scholar 

  41. Schuster C. R.: Intravenous drug use and AIDS prevention. Public Health Rep 103:261–266, 1988.

    PubMed  CAS  Google Scholar 

  42. Sells S. B.: Treatment effectiveness, in DuPont R. L., Goldstein A., O’Donnell J. (eds): Handbook on Drug Abuse. Washington, National Institute on Drug Abuse, 1979, pp 105–120.

    Google Scholar 

  43. Sells S. B., Simpson D. D. : The case for drug abuse treatment effectiveness, based on the DARP research program. Br J Addict 75:117–131, 1980.

    Article  PubMed  CAS  Google Scholar 

  44. Senay E. C.: Methadone maintenance treatment. Int J Addict 20:803–821, 1985.

    PubMed  CAS  Google Scholar 

  45. Simpson D. D., Savage L. J.: Drug abuse treatment readmissions and outcomes: Three-year follow-up of DARP patients. Arch Gen Psychiatry 37:896–901, 1980.

    Article  PubMed  CAS  Google Scholar 

  46. Snyder S. H.: Opiate receptors in the brain. N Engl J Med 296:266–278, 1977.

    Article  PubMed  CAS  Google Scholar 

  47. Stimmel B., Adamsons K. : Narcotic dependency in pregnancy: Methadone maintenance compared to use of street drugs. JAMA 235:1121–1124, 1976.

    Article  PubMed  CAS  Google Scholar 

  48. US Department of Health, Education and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration: Clinical management during pregnancy, in: Drug Dependence in Pregnancy: Clinical Management of Mother and Child. National Institute on Drug Abuse, Services Research Monograph Series, 1979, Chapter 3.

    Google Scholar 

  49. US Department of Health, Education and Welfare, Alcohol, Drug Abuse and Mental Health Administration: Management of labor, delivery and immediate post-partum period, in: Drug Dependence in Pregnancy: Clinical Management of Mother and Child. National Institute on Drug Abuse, Services Research Monograph Series, 1979, Chapter 4.

    Google Scholar 

  50. Vaillant G. E.: A 20-year follow-up of New York narcotic addicts. Arch Gen Psychiatry 29:237–241, 1973.

    Article  PubMed  CAS  Google Scholar 

  51. Washton A. M., Resnick R. B., Geyer G.: Opiate withdrawal using lofexidine, a clonidine analogue with fewer side effects. J Clin Psychiatry 44:335–337, 1983.

    PubMed  CAS  Google Scholar 

  52. Wikler A.: Dynamics of drug dependence. Arch Gen Psychiatry 28:611–616, 1973.

    Article  PubMed  CAS  Google Scholar 

  53. Zelson C., Lee S. J., Casalino M. : Neonatal narcotic addiction: Comparative effects of maternal intake of heroin and methadone. N Engl J Med 289:1216–1220, 1973.

    Article  PubMed  CAS  Google Scholar 

  54. <BibsectionHD>Sedatives, Hypnotics, and Anxiolytics</BibsectionHD>

    Google Scholar 

  55. Abuse of benzodiazepines: The problems and the solutions. A report of a Committee of the Institute for Behavior and Health, Inc. Am J Drug Alcohol Abuse 14(Suppl 1):1–16, 1988.

    Article  Google Scholar 

  56. Braestrup C., Squires R. F.: Brain specific benzodiazepine receptors. Br J Psychiatry 133:249–260, 1978.

    Article  PubMed  CAS  Google Scholar 

  57. Cohen L. S., Rosenbaum J. F.: Clonazepam: New uses and potential problems. J Clin Psychiatry 48(Suppl 10):50–55, 1987.

    PubMed  Google Scholar 

  58. Cronin R. J., Klingler E. L., Jr., Avashti P. S., et al: The treatment of nonbarbiturate sedative overdosage, in Browne, P. G. (ed): A Treatment Manual for Acute Drug Abuse Emergencies. Washington, National Institute on Drug Abuse, 1974, pp 58–62.

    Google Scholar 

  59. Dorpat T. L.: Drug automatism, barbiturate poisoning and suicide behavior. Arch Gen Psychiatry 31:216–220, 1974.

    Article  PubMed  CAS  Google Scholar 

  60. Dupont R. L. (ed): Abuse of benzodiazepines: The problems and the solutions. Am J Drug Alcohol Abuse 14(Suppl. 1):1–69, 1988.

    Google Scholar 

  61. Fleischhacker W. W., Barnas C., Hackenberg B.: Epidemiology of benzodiazepine dependence. Acta Psychiatr Scand 74(1):80–83, 1986.

    Article  PubMed  CAS  Google Scholar 

  62. Gelenberg A. J.: Benzodiazepine withdrawal. Mass Gen Hosp Newslett Biol Ther Psychiatry Newslett 3:9–12, 1980.

    Google Scholar 

  63. Herman J. B., Rosenbaum J. F., Brotman A. W. : The alprazolam to clonazepam switch for the treatment of panic disorder. J Clin Psychopharmacol 7(3):175–178, 1987.

    Article  PubMed  CAS  Google Scholar 

  64. Juergens S. M., Morse R. M.: Alprazolam dependence in seven patients. Am J Psychiatry 145(5):625–627, 1988.

    PubMed  CAS  Google Scholar 

  65. Mellman T. A., Uhde T. W.: Withdrawal syndrome with gradual tapering of alprazolam. Am J Psychiatry 143(11):1464–1466, 1986.

    PubMed  CAS  Google Scholar 

  66. Noyes R., Jr., Clancy J., Coryell W. H., et al: A withdrawal syndrome after abrupt discontinuation of alprazolam. Am J Psychiatry 142(1):114–116, 1985.

    PubMed  Google Scholar 

  67. Noyes R., Jr., Perry P. J., Crowe R. R. : Seizures following the withdrawal of alprazolam. J Nerv Ment Dis 174(1):50–52, 1986.

    Article  PubMed  Google Scholar 

  68. Pevnick J. S., Jasinski D. R., Haertzen C. A.: Abrupt withdrawal from therapeutically administered diazepam. Arch Gen Psychiatry 35:995–998, 1978.

    Article  PubMed  CAS  Google Scholar 

  69. Piesiur-Strehlow B., Strelow U., Poser W.: Mortality of patients dependent on benzodiazepines. Acta Psychiatr Scand 73(3):330–335, 1986.

    Article  PubMed  CAS  Google Scholar 

  70. Preskorn S. H., Denner L. J.: Benzodiazepines and withdrawal psychosis. Report of three cases. JAMA 237(1):36–38, 1977.

    Article  PubMed  CAS  Google Scholar 

  71. Ray W. A., Blazer D. G., Schaffner W.: Reducing long-term diazepam prescribing in office practice. JAMA 256 (18):2536–2539, 1986.

    Article  PubMed  CAS  Google Scholar 

  72. Setter J. G.: Emergency treatment of acute barbiturate intoxication, in Browne P. G. (ed): A Treatment Manual for Acute Drug Abuse Emergencies. Washington, National Institute on Drug Abuse, 1974, pp 49–53.

    Google Scholar 

  73. Smith D. E., Wesson D. R.: Phenobarbital technique for treatment of barbiturate dependence. Arch Gen Psychiatry 24:56–60, 1971.

    Article  PubMed  CAS  Google Scholar 

  74. Smith D. E., Wesson D. R., Seymour R. B.: The abuse of barbiturates and other sedative— hypnotics, in DuPont R. L., Goldstein A., O’Donnell J. (eds): Handbook on Drug Abuse. Washington, National Institute on Drug Abuse, 1979, pp 233–240.

    Google Scholar 

  75. Swartzburg M., Lieb J., Schwartz A. H.: Methaqualone withdrawal. Arch Gen Psychiatry 29:46–47, 1973.

    Article  PubMed  CAS  Google Scholar 

  76. Tennant F. S., Jr., Pumphrey E. A. : Benzodiazepine dependence of several years duration: clinical profile and therapeutic benefits. Natl Inst Drug Abuse Res Monogr 55:211–216, 1984.

    Google Scholar 

Alcohol

  1. Adams R. D., Victor M. : Principles of Neurology. New York, McGraw-Hill, 1985, pp 808–824.

    Google Scholar 

  2. Bean M.: Alcoholics Anonymous: Chapter I: Principles and methods. Psychiatr Ann 5:7–21, 1975.

    Google Scholar 

  3. Blume S. B.: Women and alcohol. A review. JAMA 256(11):1467–1470, 1986.

    Article  PubMed  CAS  Google Scholar 

  4. Brown C. G.: The alcohol withdrawal syndrome. Ann Emerg Med 11(5):276–280, 1982.

    Article  PubMed  CAS  Google Scholar 

  5. Ciraulo D. A., Barnhill J. G., Greenblatt D. J.: Abuse liability and clinical pharmacokinetics of alprazolam in alcoholic men. J Clin Psychiatry 49(9):333–337, 1988.

    PubMed  CAS  Google Scholar 

  6. Cloninger C. R.: Neurogenetic adaptive mechanisms in alcoholism. Science 236:410–416, 1987.

    Article  PubMed  CAS  Google Scholar 

  7. Cohen S. (ed): The treatment of alcoholism: Does it work? Drug Abuse Alcoholism Newslett 7:1–3, 1978.

    Google Scholar 

  8. Coles C. D., Smith I., Fernhoff P. M.: Neonatal neurobehavioral characteristics as correlates of maternal alcohol use during gestation. Alcoholism (NY) 9(5):454–460, 1985.

    CAS  Google Scholar 

  9. Council on Scientific Affairs: Aversion Therapy. JAMA 258(18):2562–2566, 1987.

    Article  Google Scholar 

  10. Edwards G., Orford J., Egert S., et al: Alcoholism: A controlled trial of“treatment” and“advice.” J Stud Alcohol 38:1004–1031, 1977.

    PubMed  CAS  Google Scholar 

  11. Emrick C. E.: A review of psychologically oriented treatment of alcoholism: II. The relative effectiveness of different treatment approaches and the effectiveness of treatment versus no treatment. J Stud Alcohol 36:88–108, 1975.

    PubMed  CAS  Google Scholar 

  12. Emrick C. E.: Alcoholics Anonymous: Affilitation processes and effectiveness as treatment. Alcoholism (NY) 11(5):416–423, 1987.

    CAS  Google Scholar 

  13. Erhart C. B., Wolf A. W., Emhart C. B., Wolf A. W., Linn P. L.: Alcohol-related birth defects: Syndromal anomalies, intrauterine growth retardation, and neonatal behavioral assessment. Alcoholism (NY) 9(5):447–453, 1985.

    Google Scholar 

  14. Frances R. J.: Update on alcohol and drug disorder treatment. J Clin Psychiatry 49(Suppl):13–17, 1988.

    PubMed  Google Scholar 

  15. Fuller R. K., Roth H. P.: Disulfiram for the treatment of alcoholism. Ann Intern Med 90:901–904, 1979.

    PubMed  CAS  Google Scholar 

  16. Kwentus M. D., Major L. F.: Disulfiram in the treatment of alcoholism. J Stud Alcohol 40:428–446, 1979.

    PubMed  CAS  Google Scholar 

  17. Linnoila M., Mefford I., Nutt D. W. : NIH conference. Alcohol withdrawal and noradrenergic function. Ann Intern Med 107(6):875–889, 1987.

    PubMed  CAS  Google Scholar 

  18. Liskow B. I., Goodwin D. W. : Pharmacological treatment of alcohol intoxication, withdrawal and dependence: A critical review. J Stud Alcohol 48(4):356–370, 1987.

    PubMed  CAS  Google Scholar 

  19. Liskow B., Mayfield D., Thiele J. : Alcohol and affective disorder: Assessment and treatment. J Clin Psychiatry 43(4):144–147, 1982.

    PubMed  CAS  Google Scholar 

  20. Mendelson J. H., Babor T. F., Mello N. K., et al: Alcoholism and prevalence of medical and psychiatric disorders. J Stud Alcohol 47(5):361–366, 1986.

    PubMed  CAS  Google Scholar 

  21. Mendelson J. H., Mello N. K.: Biologic concomitants of alcoholism. N Engl J Med 301:912–921, 1979.

    Article  PubMed  CAS  Google Scholar 

  22. Mendelson J. H., Mello N. K. (eds): The Diagnosis and Treatment of Alcoholism, 2nd ed. New York. McGraw-Hill.

    Google Scholar 

  23. Meyer R. E., Kranzier H. R.: Alcoholism: Clinical implications of recent research. J Clin Psychiatry 49(Suppl):8–12, 1988.

    PubMed  Google Scholar 

  24. Newsom G., Murray N.: Reversal of dexamethasone suppression test nonsuppression in alcohol abusers. Am J Psychiatry 140(3):353–354, 1983.

    PubMed  CAS  Google Scholar 

  25. Ng S. K., Hauser W. A., Brust J. C.: Alcohol consumption and withdrawal in new-onset seizures. N Engl J Med 319(11):666–673, 1988.

    Article  PubMed  CAS  Google Scholar 

  26. Ouelette E. M., Rosett H. L., Rosman N. P., et al: Adverse effects on offspring of maternal alcohol abuse during pregnancy. N Engl J Med 297:528–530, 1977.

    Article  Google Scholar 

  27. Pomerleau O., Pertschuk M., Stunnett J.: A critical examination of some current assumptions in the treatment of alcoholism. J Stud Alcohol 37:849–867, 1976.

    PubMed  CAS  Google Scholar 

  28. Schuckit M. A.: A clinical review of alcohol, alcoholism and the elderly patient. J Clin Psychiatry 43:396–399, 1982.

    PubMed  CAS  Google Scholar 

  29. Sellers E. M., Naranjo C. A., Peachey J. E. : Drug therapy: Drugs to decrease alcohol consumption. N Engl J Med 305(21):1255–1262, 1981.

    Article  PubMed  CAS  Google Scholar 

  30. Stabenau J. R.: Implications of family history of alcoholism, antisocial personality, and sex differences in alcohol dependence. Am J Psychiatry 141(10):1178–1182, 1984.

    PubMed  CAS  Google Scholar 

  31. Staiesey N. L., Fried P. A. : Relationships between moderate maternal and alcohol consumption during pregnancy and infant neurological development. J Stud Alcohol 44(2):262–270, 1983.

    Google Scholar 

  32. Streissguth A. P., Clarren S. K., Jones K. L.: Natural history of the fetal alcohol syndrome: A 10 year follow-up of eleven patients. Lancet 2(8446):85–91, 1985.

    Article  PubMed  CAS  Google Scholar 

  33. Streissguth A. P., Sampson P. D., Barr H. M. : Studying alcohol teratogenesis from the perspective of the fetal alcohol syndrome: Methodological and statistical issues. Ann NY Acad Sci 488:73–86, 1986.

    Google Scholar 

  34. Thompson W. L., Johnson A. D., Maddrey W. L., et al: Diazepam and paraldehyde for treatment of severe delirium tremens: A controlled trial. Ann Intern Med 82:175–180, 1975.

    PubMed  CAS  Google Scholar 

  35. Vaillant G. E.: The Natural History of Alcoholism: Causes, Patterns, and Paths of Recovery. Cambridge, MA, Harvard University Press, 1985.

    Google Scholar 

  36. Vaillant G. E.: Natural history of male psychological health: VIII. Antecedents of alcoholism and“orality.“ Am J Psychiatry 137:181–186, 1980.

    Article  PubMed  CAS  Google Scholar 

  37. Warren K. R., Bast R. J.: Alcohol-related birth defects: An update. Public Health Rep 103(6):638–642, 1988.

    PubMed  CAS  Google Scholar 

  38. Weissman M. M., Myers J. K.: Clinical depression in alcoholism. Am J Psychiatry 137:372–374, 1980.

    PubMed  CAS  Google Scholar 

  39. Wilson G. T.: Chemical aversion conditioning as a treatment for alcoholism: A reanalysis. Behav Res Ther 25(6):503–516, 1987.

    Article  PubMed  CAS  Google Scholar 

  40. Wright C., Vafier J. A., Lake C. R.: Disulfiram-induced fulminating hepatitis: Guidelines for liver panel monitoring. J Clin Psychiatry 49:430–434, 1988.

    PubMed  Google Scholar 

Cocaine

  1. Aigner T. G., Balster R. L.: Choice behavior in rhesus monkeys: Cocaine versus food. Science 201:534–535, 1978.

    Article  PubMed  CAS  Google Scholar 

  2. Byck R., Van Dyke C.: What are the effects of cocaine in man? in Peterson R. C., Stillman R. C. (eds): Cocaine: 1977. Washington, National Institute on Drug Abuse, Research Monograph 13, 1977, pp 5–16.

    Google Scholar 

  3. Chasnoff I., MacGregor S., Chisum G.: Cocaine use during pregnancy: Adverse perinatal outcome, in: Problems of Drug Dependence, 1987, Proceedings of the 49th Annual Scientific Meeting, Committee on Problems of Drug Dependence, Inc. Washington, National Institute on Drug Abuse Research, Monograph 81, 1988, p 265.

    Google Scholar 

  4. Crack. Med Lett 28:69–70, 1986.

    Google Scholar 

  5. Cregler L. L., Mark H.: Special report: Medical complications of cocaine abuse. N Engl J Med 315:1495–1500, 1986.

    Article  PubMed  CAS  Google Scholar 

  6. Ellinwood E. H., Jr.: Amphetamine psychosis: Individuals, settings and sequences, in Ellinwood E. H., Cohen S. (eds): Current Concepts on Amphetamine Abuse. Washington, National Institute of Mental Health, 1972, pp 143–158.

    Google Scholar 

  7. Ellinwood E. H., Jr.: Amphetamines/anorectics, in DuPont R. L., Goldstein A., O’Donnell J. (eds): Handbook on Drug Abuse. Washington, National Institute on Drug Abuse, 1979, pp 221–231.

    Google Scholar 

  8. Finnegan L.: The dilemma of cocaine exposure in the perinatal period, in: Problems of Drug Dependence, 1987, Proceedings of the 49th Annual Scientific Meeting, Committee on Problems of Drug Dependence, Inc. Washington, National Institute on Drug Abuse, Research Monograph 81, 1988, p 379.

    Google Scholar 

  9. Fischman M. W., Schuster C. R., Resnekov L., et al: Cardiovascular and subjective effects of intravenous cocaine administration in humans. Arch Gen Psychiatry 33:983–989, 1976.

    Article  PubMed  CAS  Google Scholar 

  10. Gawin F. H., Ellinwood E. H.: Cocaine and other stimulants: Actions, abuse and treatment. N Engl J Med 318:1173–1182, 1988.

    Article  PubMed  CAS  Google Scholar 

  11. Gawin F. H., Kleber H. D.: Abstinence symptomatology and psychiatric diagnosis in cocaine abusers: Clinical observations. Arch Gen Psychiatry 43:107–113, 1986.

    Article  PubMed  CAS  Google Scholar 

  12. Gawin F. H., Kleber H. D.: Pharmacologic treatments of cocaine abuse. Psychiatr Clin North Am 9:573–583, 1986.

    PubMed  CAS  Google Scholar 

  13. Gawin F. H., Kleber H. D., Byck R., et al: Desipramine facilitation of initial cocaine abstinence. Arch Gen Psychiatry 46:117–121, 1989.

    Article  PubMed  CAS  Google Scholar 

  14. Giannini A. J., Malone D. A., Giannini M. C.: Treatment of depression in chronic cocaine and phencyclidine abuse with desipramine. J Clin Pharmacol 26:211–214, 1986.

    PubMed  CAS  Google Scholar 

  15. Grinspoon L., Hedblom P.: The Speed Culture: Amphetamine Use and Abuse in America. Cambridge, Harvard University Press, 1975.

    Google Scholar 

  16. Isner J. M., Estes M., Thompson P. D., et al: Acute cardiac events temporarily related to cocaine abuse. N Engl J Med 315:1438–1443, 1986.

    Article  PubMed  CAS  Google Scholar 

  17. Javaid J. I., Fischman M. W., Schuster C. R., et al: Cocaine plasma concentration: Relation to physiological and subjective effects in humans. Science 202:227–228, 1978.

    Article  PubMed  CAS  Google Scholar 

  18. Kramer J. C.: Introduction to amphetamine abuse, in Ellinwood E. H., Cohen S. (eds): Current Concepts on Amphetamine Abuse. Washington, National Institute of Mental Health, 1972, pp 177–184.

    Google Scholar 

  19. Kramer J. C., Fischman V. S., Littlefield D. C.: Amphetamine abuse: Pattern and effects of high doses taken intravenously. JAMA 201:89–93, 1967.

    Article  Google Scholar 

  20. Mody C. K., Miller B. L., McIntyre H. B., et al: Neurologic complications of cocaine abuse. Neurology 38:1189–1193, 1988.

    Article  PubMed  CAS  Google Scholar 

  21. Pollack M. H., Brotman A. W., Rosenbaum J. F.: Cocaine abuse and treatment. Compr Psychiatry 30:31–44, 1989.

    Article  PubMed  CAS  Google Scholar 

  22. Post R. M.: Cocaine psychoses: A continuum model. Am J Psychiatry 132:225–231, 1975.

    PubMed  CAS  Google Scholar 

  23. Post R. M., Kotin J., Goodwin F. K.: The effects of cocaine on depressed patients. Am J Psychiatry 131:511–517, 1974.

    PubMed  CAS  Google Scholar 

  24. Resnick R. B., Kestenbaum R. S.: Acute systemic effects of cocaine in man: A controlled study by intranasal and intravenous routes. Science 195:696–698, 1977.

    Article  PubMed  CAS  Google Scholar 

  25. Rosenfeld W., Zabaleta I., Sahdev R., et al: Maternal use of cocaine, methadone, heroin and alcohol: Comparison of neonatal effects, in: Problems of Drug Dependence, 1987, Proceedings of the 49th Annual Scientific Meeting, Committee on Problems of Drug Dependence, Inc. Washington, National Institute on Drug Abuse, Research Monograph 81, 1988, p 264.

    Google Scholar 

  26. Roth D., Alarcon F. J., Fernandez J. A.: Acute rhabdomyolysis associated with cocaine intoxication. N Engl J Med 319:673–677, 1988.

    Article  PubMed  CAS  Google Scholar 

  27. Smith D. E., Wesson D. R., Buxton M. E., et al (eds): Amphetamine Use, Misuse and Abuse: Proceedings of the National Conference. Boston, G. K. Hall, 1979.

    Google Scholar 

  28. Washton A. M.: Nonpharmacologic treatment of cocaine abuse. Psychiatr Clin North Am 9:563–571, 1986.

    PubMed  CAS  Google Scholar 

  29. Weiss R. D.: Relapse to cocaine abuse after initiating desipramine treatment. JAMA 260:2545–2546, 1988.

    Article  PubMed  CAS  Google Scholar 

  30. Weiss R. D., Gawin F. H.: Protracted elimination of cocaine metabolites in long term high-dose cocaine abusers. Am J Med 85:879–880, 1988.

    Article  PubMed  CAS  Google Scholar 

  31. Weiss R. D., Mirin S. M.: Cocaine. Washington, American Psychiatric Press, 1987.

    Google Scholar 

  32. Weiss R. D., Mirin S. M.: Subtypes of cocaine abusers. Psychiatr Clin North Am 9:491–501, 1986.

    PubMed  CAS  Google Scholar 

  33. Weiss R. D., Mirin S. M., Griffin M. L., et al: Psychopathology in cocaine abusers: Changing trends. J Nerv Ment Dis 176:719–725, 1988.

    Article  PubMed  CAS  Google Scholar 

  34. Weiss R. D., Mirin S. M., Michael J. L., et al: Psychopathology in chronic cocaine abusers. Am J Drug Alcohol Abuse 12:17–29, 1986.

    Article  PubMed  CAS  Google Scholar 

  35. Woods, J. R., Plessinger M. A., Clark K. E.: Effect of cocaine on uterine blood flow and fetal oxygenation. JAMA 257:957–961, 1987.

    Article  PubMed  CAS  Google Scholar 

Hallucinogens

  1. Abraham H. D.: Visual phenomenology of the LSD flashback. Arch Gen Psychiatry 40:884–889, 1983.

    Article  PubMed  CAS  Google Scholar 

  2. Blacker K. H., Reese T. J., Stone G. C., et al: Chronic users of LSD: The“acidheads.” Am J Psychiatry 125:341–351, 1968.

    Google Scholar 

  3. Bowers M. B., Jr.: Acute psychosis induced by psychotomimetic drug abuse. I. Clinical findings. Arch Gen Psychiatry 27:437–439, 1972.

    Article  PubMed  Google Scholar 

  4. Bowers M. B., Jr.: Acute psychosis induced by psychotomimetic drug abuse. II. Neurochemical findings. Arch Gen Psychiatry 27:440–442, 1972.

    Article  PubMed  Google Scholar 

  5. Bowers M. B., Jr., Chipman A., Schwartz A., et al: Dynamics of psychedelic drug abuse: A clinical study. Arch Gen Psychiatry 16:560–566, 1967.

    Article  PubMed  CAS  Google Scholar 

  6. Brawley P., Duffield J. C.: The pharmacology of hallucinogens. Pharmacol Rev 24:31–66, 1972.

    PubMed  CAS  Google Scholar 

  7. Cohen S.: Flashbacks. Drug Abuse Alcoholism Newslett 6:1–3, 1977.

    Google Scholar 

  8. Faillace L. A., Snyder S. H., Weingartner H.: 2,5-Dimethoxy-l-methylamphetamine: Clinical evaluation of a new hallucinogenic drug. J Nerv Ment Dis 150:119–126, 1970.

    Article  PubMed  CAS  Google Scholar 

  9. Freedman D. X.: The use and abuse of LSD. Arch Gen Psychiatry 18:330–347, 1968.

    Article  PubMed  CAS  Google Scholar 

  10. Gilmour D. G., Bloom A. D., Lele K. P., et al: Chromosomal aberrations in users of psychoactive drugs. Arch Gen Psychiatry 24:268–272, 1971.

    Article  PubMed  CAS  Google Scholar 

  11. Glass G. S., Bowers M. B., Jr. : Chronic psychosis associated with long-term psychotomimetic drug abuse. Arch Gen Psychiatry 23:97–102, 1970.

    Article  PubMed  CAS  Google Scholar 

  12. Grinspoon L., Bakalar J. B.: Psychedelic Drugs Reconsidered. New York, Basic Books, 1979.

    Google Scholar 

  13. Jacobson C. B., Berlin C. M.: Possible reproductive detriment in LSD users. JAMA 222:1367–1373, 1972.

    Article  PubMed  CAS  Google Scholar 

  14. McGlothlin W. H., Arnold D. O.: LSD revisited. Arch Gen Psychiatry 24:35–49, 1971.

    Article  PubMed  CAS  Google Scholar 

  15. McGlothlin W. H., Arnold D. O., Freedman D. X.: Organicity measures following repeated LSD ingestion. Arch Gen Psychiatry 21:704–709, 1969.

    Article  PubMed  CAS  Google Scholar 

  16. Snyder S. H., Faillace L. A., Weingartner H.: DOM (STP), a new hallucinogenic drug, and DOET: Effects in normal subjects. Am J Psychiatry 125:113–120, 1968.

    PubMed  CAS  Google Scholar 

  17. Snyder S. H., Weingartner H., Faillace L. A.: DOET (2,5-dimethoxy-4-ethylamphetamine), a new psychotropic drug: Effects of varying doses in man. Arch Gen Psychiatry 24:50–55, 1971.

    Article  PubMed  CAS  Google Scholar 

  18. Tucker G. J., Quinlan D., Harrow M.: Chronic hallucinogenic drug use and thought disturbance. Arch Gen Psychiatry 27:443–447, 1972.

    Article  PubMed  CAS  Google Scholar 

Phencyclidine

  1. Clouet D. H. (ed): Phencyclidine: An Update. Washington, National Institute on Drug Abuse, 1986.

    Google Scholar 

  2. Domino E. F.: Treatment of phencyclidine intoxication. Psychopharmacol Bull 16:83–85, 1980.

    PubMed  CAS  Google Scholar 

  3. Fauman M. A., Fauman B. J.: The psychiatric aspects of chronic phencyclidine use: A study of chronic PCP users, in Peterson R. C., Stillman R. C. (eds): PCP: Phencyclidine Abuse: An Appraisal. Washington, National Institute on Drug Abuse, Research Monograph 21, DHEW Publ . No. 78–728, 1978, pp 183–200.

    Google Scholar 

  4. Gelenberg A. J.: Psychopharmacology update: Phencyclidine. McLean Hosp J 2:89–96, 1977.

    Google Scholar 

  5. Graeven D. B.: Patterns of phencyclidine use, in Peterson R. C., Stillman R. C. (eds): PCP: Phencyclidine Abuse: An Appraisal. Washington, National Institute on Drug Abuse, Research Monograph 21, DHEW Publ. No. 78–728, 1978, pp 176–182.

    Google Scholar 

  6. Luisada P. V.: The phencyclidine psychosis: Phenomenology and treatment, in Peterson R. C., Stillman R. C. (eds): PCP: Phencyclidine Abuse: An Appraisal. Washington, National Institute on Drug Abuse, Research Monograph 21, DHEW Publ. No. 78–728, 1978, pp 241–253.

    Google Scholar 

  7. Peterson R. C., Stillman R. C.: Phencyclidine: An overview, in Peterson R. C., Stillman R. C. (eds): PCP: Phencyclidine Abuse: An Appraisal. Washington, National Institute on Drug Abuse, Research Monograph 21, DHEW Publ. No. 78–728, 1978, pp 1–17.

    Google Scholar 

  8. Smith D. R., Wesson D. R., Buxton M. E., et al: The diagnosis and treatment of the PCP abuse syndrome, in Peterson R. C., Stillman R. C. (eds): PCP: Phencyclidine Abuse: An Appraisal. Washington, National Institute on Drug Abuse, Research Monograph 21, DHEW Publ. No. 78–728, 1978, pp 229–240.

    Google Scholar 

Inhalants

  1. Cohen S.: Inhalants, in DuPont R. L., Goldstein A., O’Donnell J. (eds): Handbook on Drug Abuse, Washington, National Institute on Drug Abuse, 1979, pp 213–220.

    Google Scholar 

  2. Glaser F. B.: Inhalation psychosis and related states, in Browne P. G. (ed): A Treatment Manual for Acute Drug Abuse Emergencies. Washington, National Institute on Drug Abuse, 1975, pp 95–104.

    Google Scholar 

  3. Lewis J. D., Moritz D., Mellis L. P.: Long-term toluene abuse. Am J Psychiatry 138:368–370, 1981.

    PubMed  CAS  Google Scholar 

  4. Westermeyer J.: The psychiatrist and solvent–inhalant abuse: Recognition, assessment, and treatment. Am J Psychiatry 144:903–907, 1987.

    PubMed  CAS  Google Scholar 

Marijuana

  1. Benedikt R. A., Cristofaro P., Mendelson J. H., et al: Effects of acute marijuana smoking in postmenopausal women. Psychopharmacology 90:14–17, 1986.

    Article  PubMed  CAS  Google Scholar 

  2. Bernstein J. G.: Marijuana—new potential, new problems. Drug Ther10:38–48, 1980.

    Google Scholar 

  3. Chopra G. S., Smith J. W.: Psychotic reactions following cannabis use in East Indians. Arch Gen Psychiatry 30:24–27, 1974.

    Article  PubMed  CAS  Google Scholar 

  4. Cohen S.: Cannabis: Impact on motivation. Part I. Drug Abuse Alcoholism Newslett 9:1–3, 1980.

    Google Scholar 

  5. Cohen S.: Cannabis: Impact on motivation. Part II. Drug Abuse Alcoholism Newslett 10:1–3, 1981.

    Google Scholar 

  6. Harding T., Knight F.: Marijuana-modified mania. Arch Gen Psychiatry 29:635–637, 1973.

    Article  CAS  Google Scholar 

  7. Jones R. T.: Marijuana-induced“high“: Influence of expectation, setting and previous drug experience. Pharmacol Rev 23:359–369, 1971.

    PubMed  CAS  Google Scholar 

  8. Kupfer D. J., Detre T., Koral J., et al: A comment on the“amotivational syndrome“ in marijuana smokers. Am J Psychiatry 130:1319–1322, 1973.

    PubMed  CAS  Google Scholar 

  9. Melges F. T., Tinklenberg J. R., Hollister L. E., et al: Temporal disintegration and depersonalization during marijuana intoxication. Arch Gen Psychiatry 23:204–210, 1970.

    Article  PubMed  CAS  Google Scholar 

  10. Mendelson J. H.: Marijuana, in Meltzer H. Y. (ed): Psychopharmacology: The Third Generation of Progress. New York, Raven Press, 1987, pp 1565–1571.

    Google Scholar 

  11. Mendelson J. H., Ellingboe J., Kuehnle J. C., et al: Effects of chronic marijuana use on integrated plasma testosterone and luteinizing hormone levels. J Pharmacol Exp Ther 207:611–617, 1978.

    PubMed  CAS  Google Scholar 

  12. Mendelson J. H., Mello N. K., Ellingboe J., et al: Marijuana smoking suppresses luteinizing hormone in women. J Pharmacol Exp Ther 237:862–886, 1986.

    PubMed  CAS  Google Scholar 

  13. Mendelson J. H., Rossi A. M., Meyer R. E. (eds): The Use of Marijuana: A Psychological and Physiological Inquiry. New York, Plenum Press, 1974.

    Google Scholar 

  14. Meyer R. E.: Psychiatric consequences of marijuana use: The state of the evidence, in Tinklenberg J. R. (ed): Marijuana and Health Hazards. Methodological Issues in Current Research. New York, Academic Press, 1975, pp 133–152.

    Google Scholar 

  15. Millman R. B., Sbriglio R.: Patterns of use and psychopathology in chronic marijuana users. Psychiatr Clin North Am 9:533–545, 1986.

    PubMed  CAS  Google Scholar 

  16. Mirin S. M., Shapiro L. M., Meyer R. E., et al: Casual versus heavy use of marijuana: A redefinition of the marijuana problem. Am J Psychiatry 127:54–60, 1971.

    Google Scholar 

  17. Peterson R. C. (ed): Marijuana Research Findings: 1980. Washington, National Institute on Drug Abuse, Research Monograph 31, 1980.

    Google Scholar 

  18. Schnoll S. H., Daghestani A. N.: Treatment of marijuana abuse. Psychiatr Ann 16:249–257, 1986.

    Google Scholar 

  19. Tashkin D. P., Shapiro B. J., Lee Y. E.: Subacute effects of heavy marijuana smoking on pulmonary function in healthy men. N Engl J Med 294:125–129, 1976.

    Article  PubMed  CAS  Google Scholar 

  20. Tennant F. S.: The clinical syndrome of marijuana dependence. Psychiatr Ann 16:225–234, 1986.

    Google Scholar 

  21. Tennant F. S., Jr., Groesbeck C. J.: Psychiatric effects of hashish. Arch Gen Psychiatry 27:133–136, 1972.

    Article  PubMed  Google Scholar 

  22. Thacore V. R., Shukla S. R. P.: Cannabis psychosis and paranoid schizophrenia. Arch Gen Psychiatry 33:383–386, 1976.

    Article  PubMed  CAS  Google Scholar 

  23. Treffert D. A.: Marijuana use in schizophrenia: A clear hazard. AmJ Psychiatry 135:1213–1220, 1978.

    CAS  Google Scholar 

  24. Weil A. T.: Adverse reactions to marijuana: Classification and suggested treatment. N Engl J Med 282:997–1000, 1970.

    Article  PubMed  CAS  Google Scholar 

  25. Wu T., Tashkin D. P., Djahed B., et al: Pulmonary hazards of smoking marijuana as compared with tobacco. N Engl J Med 318:347–351, 1988.

    Article  PubMed  CAS  Google Scholar 

  26. Zuckerman B., Frank D. A., Hingson R., et al: Effects of maternal marijuana and cocaine use on fetal growth. N Engl J Med 320:762–768, 1989.

    Article  PubMed  CAS  Google Scholar 

“Designer“ Drugs: MDMA and MDEA

  1. Dowing G. P., McDonough E. T., Bost R. O.: ‘Eve’ and ‘ecstasy’: A report of five deaths associated with the use of MDEA and MDMA. JAMA 257:1615–1617, 1987.

    Article  Google Scholar 

  2. Greer G., Strassman R. J.: Information on“ecstasy.“ Am J Psychiatry 142:1391, 1985.

    PubMed  CAS  Google Scholar 

  3. Newmeyer J. A.: Some considerations on the prevalence of MDMA use. J Psychoactive Drugs 18:361–362, 1986.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. McLean Hospital, Belmont, Massachusetts, 02178, USA

    Steven M. Mirin M.D. & Shelly F. Greenfield M.D.

  2. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Steven M. Mirin M.D., Roger D. Weiss M.D. & Shelly F. Greenfield M.D.

  3. Alcohol and Drug Abuse Program, McLean Hospital, Belmont, Massachusetts, 02178, USA

    Roger D. Weiss M.D.

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  1. Steven M. Mirin M.D.
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Editor information

Editors and Affiliations

  1. University of Arizona Health Sciences Center, Tucson, Arizona, USA

    Alan J. Gelenberg M.D.

  2. The Better Homes Foundation, Newton Centre, Massachusetts, USA

    Ellen L. Bassuk M.D.

  3. Harvard Medical School, Boston, Massachusetts, USA

    Ellen L. Bassuk M.D.

  4. Schoonover Associates, Newton Centre, Massachusetts, USA

    Stephen C. Schoonover M.D.

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Mirin, S.M., Weiss, R.D., Greenfield, S.F. (1991). Psychoactive Substance Use Disorders. In: Gelenberg, A.J., Bassuk, E.L., Schoonover, S.C. (eds) The Practitioner’s Guide to Psychoactive Drugs. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1137-0_7

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