Cytologically recognizable chromosome damage includes both structural aberrations, in which a gross change in morphology of the chromosome has occurred, and sister chromatid exchange, which does not result in a change in chromosome morphology. Sister chromatid exchange was the subject of a talk elsewhere in these proceedings and I shall devote this presentation to structural aberrations — their spontaneous and induced incidence in human cells, and the significance of these changes to the cell or the individual.


Chronic Myeloid Leukemia Chromosome Aberration Sister Chromatid Exchange Male Breast Cancer Chromosome Damage 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Paul E. Perry
    • 1
  1. 1.MRC Clinical & Population Cytogenetics UnitWestern General HospitalEdinburghScotland

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