Induction of Sister Chromatid Exchange by Chemical Mutagens

  • Paul E. Perry

Abstract

Cytogenetics underwent something of a revolution in the mid 1970s with the development of new techniques for the visualization of sister chromatid exchange (SCE). One of the reasons for the excitement was the observation that many chemical mutagens elicted dose dependent increases in the frequency of SCEs, and since these events proved to be simple to score and the analysis of only twenty or so cells per dose point was usually sufficient for statistical purposes, this method showed considerable advantages over the conventional cytogenetic method of assessing chromosome damage, aberration scoring. There are, however, important differences between SCE and aberrations, and this is reflected in the uses we can make of these phenomena in mutagen and carcinogen identification, and in the assessment of risk.

Keywords

Sister Chromatid Exchange Chemical Mutagen Chinese Hamster Cell Cigarette Smoke Condensate Vinyl Chloride Monomer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Paul E. Perry
    • 1
  1. 1.MRC Clinical and Population Cytogenetics UnitWestern General HospitalEdinburghScotland

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