The Problem of Specificity in the Assessment of Risk from Chemicals and Radiation-Breast Cancer Models

  • Michael N. Gould

Abstract

In estimating the risk to man from radiation or chemicals one has to be concerned with specificity. These specificities include: species specificity — can we extrapolate our finding from rodents to man? organ specificity — if it can be shown that a chemical will not cause liver cancer, can we be sure that it will not cause breast cancer? individual specificity — will all women respond to breast carcinogens in a similar manner? If not, how can we identify susceptible women? I feel that many of these questions can be approached by studying primary cells in vitro from specific organs of both rodents and man. In the following discussion, I will give examples from our work to demonstrate how these questions can be examined. I will emphasize the problem of etiology of breast cancer.

Keywords

Mammary Gland United Nations Scientific Committee Human Mammary Cell Susceptible Woman Chinese Hamster Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Gould, M.N., Mammary Gland Cell Mediated Mutagenesis of Mammalian Cells by Organ Specific Carcinogens, Cancer Res. 40: 1836–1841 (1980).PubMedGoogle Scholar
  2. 2.
    Gould, M.N., Chemical Carcinogen Activation in the Rat Mammary Gland: Intra-Organ Cell Specificity, Manuscript submitted (1981).Google Scholar
  3. 3.
    United Nations Scientific Committee on the Effects of Atomic Radiation, Sources, and Effects of Ionizing Radiation. United Nations, NY 1977.Google Scholar
  4. 4.
    Thomas, F. and Gould, M.N., Evidence for the Repair of Potentially Lethal Damage in Irradiated Bone Marrow, Manuscript submitted (1981).Google Scholar
  5. 5.
    Gould, M.N. and Clifton, K.H., The Survival of Mammary Cells Following Irradiation In Vivo: A Directly Generated Single-Dose Survival Curve, Radiat. Res. 72: 343–352 (1977).Google Scholar
  6. 6.
    Gould, M.N. and Clifton, K.H., The Survival of Rat Mammary Gland Cells Following Irradiation In Vivo Under Different Endocrinological Conditions, J. Radiat. Oncol. Biol. Phy. 4: 629–673 (1978).CrossRefGoogle Scholar
  7. 7.
    Mulcahy, R.T., Gould, M.N. and Clifton, K.H., Survival of Thyroid Cells: In Vivo Irradiation and In Situ Repair, Radiat. Res. 84: 523–528 (1980).Google Scholar
  8. 8.
    Jirtle, R.L., Michalopoulous, G., McClain, J.R. and Crowley, J., The Survival of Parenchymal Hepatocytes Exposed to Ionizing Radiation, Cancer Res., in press (1981).Google Scholar
  9. 9.
    Mahler, P.A., Gould, M.N., Pearson, D.W., DeLuca, P.M. and Clifton, K.H., Rat Mammary Survival Following Irradiation with 14.3 MeV Neutrons, Radiat. Res., in press (1981).Google Scholar
  10. 10.
    Duncan, W., Green, D., Howard, A. and Massey, J.B., The RBE of 14 MeV Neutrons: Observations on Colony Forming Units in Mouse Bone Marrow, Int. J. Radiat. Biol. 15: 397–403 (1969).CrossRefGoogle Scholar
  11. 11.
    Jirtle, R.L., DeLuca, P.M. and Gould, M.N., Manuscript in Preparation (1981).Google Scholar
  12. 12.
    Huggins, C.B., Experimental Leukemia and Mammary Cancer, The University of Chicago Press, 1979.Google Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Michael N. Gould
    • 1
  1. 1.Department of Human OncologyUniversity of Wisconsin WCCCMadisonUSA

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