Cellular Specificity in DNA Damage, Repair, and Replication during Chronic Carcinogen Exposure

  • James G. Lewis
  • Mary A. Bedell
  • Kathyrn C. Billings
  • James A. Swenberg

Abstract

In order to make rational use of human cells and tissues in the evaluation of risk from chemical or physical agents, it is crucial that a better understanding of the molecular events leading to malignant transformation be reached. It is of little use simply to replace studies on animal cells with human cells unless it is known which molecular processes and changes are relevant and should be quantified. In this paper, we present data in support of the hypothesis that the replication of DNA which contains promutagenic DNA damage is necessary for the initiation of carcinogenesis. If this hypothesis is true, and the relevant types of DNA damage can be identified and monitored in human cells, the possibility of quantitatively assessing risk using human cells will be greatly enhanced.

Keywords

Cellular Specificity Cell Replication Methyl Methanesulfonate CsCl Gradient IARC Scientific Publication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Pegg, A.E. Adv. Cancer Res. 25, 195–267, 1977.PubMedCrossRefGoogle Scholar
  2. 2.
    Margison, G.P. and O’Conner, P.J. In “Chemical Carcinogens and DNA, Vol. 1” ( Grover, P.L., ed.), pp. 111–159. CRC Press Inc., Boca Raton, 1979.Google Scholar
  3. 3.
    Loveless, A. Nature 223, 206–207, 1969.PubMedCrossRefGoogle Scholar
  4. 4.
    Lawley, P.D. and Martin, C.N. Biochem. J. 145, 85–91, 1975.PubMedGoogle Scholar
  5. 5.
    Gerchman, L.L. and Ludlum, D.B. Biochem. Biophys. Acta, 308, 310–316, 1973.CrossRefGoogle Scholar
  6. 6.
    Pegg, A.E. and Nicoll, J.W. In “Screening Tests in Chemi- cal Carcinogens” (Montesano, R., ed.), pp. 571–592. IARC Scientific Publication, No. 12, Lyon, France 1976.Google Scholar
  7. 7.
    Karran, P. and Lindahl, T. Nature 280, 76–78, 1979.PubMedCrossRefGoogle Scholar
  8. 8.
    Robins, R. and Cairns, J. Nature 280, 74–76, 1979.PubMedCrossRefGoogle Scholar
  9. 9.
    Montesano, R., Bresil, H., Planche-Martel, G., Margison, G.P., and Pegg, A.E. Cancer Res. 40, 452–458, 1980.PubMedGoogle Scholar
  10. 10.
    Pegg, A.E. Biochem. Biophys. Res. Commun. 84, 166–173, 1978.PubMedCrossRefGoogle Scholar
  11. 11.
    Margison, G.P. and Kleihues, P. Biochem. J. 148, 521–525, 1975.PubMedGoogle Scholar
  12. 12.
    Cooper, H.K., Hauenstein, E., Kolar, G.F., and Kleihues, P. Acta Neuropath. (Berl) 43, 105–109, 1978.CrossRefGoogle Scholar
  13. 13.
    Margison, G.P., Margison, J.M., and Montesano, R. Biochem. J. 165, 463–468, 1977.PubMedGoogle Scholar
  14. 14.
    Wisse, E. and Knook, D.L. In “Progress in Liver Disease” Vol. 16 ( Popper, Id. and Schaffuer F., eds.) pp 153–171, Grune and Stratton, NY 1979.Google Scholar
  15. 15.
    Druckrey, H. In “Topics in Chemical Carcinogenesis” ( Nakahara, W., Takayama, S., Sugimura, T., and Odashina, S., eds.), pp. 73–151 University Park Press, Tokyo, 1972.Google Scholar
  16. 16.
    Weisburger, J.H., Madison, R.M. and Weisburger, E.K. J. Natl. 1975., Warel, J.M., Vigueva, C., Cancer Inst. 54, 1185–1188Google Scholar
  17. 17.
    Rogers, K.J. and Pegg, A.E. Cancer Res. 37, 4082–4087, 1977.PubMedGoogle Scholar
  18. 18.
    Lewis, J.G. and Swenberg, J.A. Nature 288, 185–187, 1980.PubMedCrossRefGoogle Scholar
  19. 19.
    Beland, F.A., Dooley, K.L., and Casciano, D.A. J. Chromat. 174, 177–186, 1979.CrossRefGoogle Scholar
  20. 20.
    Bedell, M.A., Lewis, J.G., Billings, K.C., and Swenberg, J.A. Cancer Res. In Press.Google Scholar
  21. 21.
    Lewis, J.G. and Swenberg, J.A. Cancer Res. 82, 87–92, 1982.Google Scholar
  22. 22.
    Abanobi, S.E., Columbano, A., Mulivor, R.A., Rajalakshmi, S., and Sarma, D.S. Biochem. 19, 1382–1387, 1980.CrossRefGoogle Scholar
  23. 23.
    Michalopoulos, G. Personnel Communication.Google Scholar
  24. 24.
    Autrup, H., Harris, C.C., Stoner, G.D., Selkirk, J.K., Schafer, P.W., and Trump, B.F. Lab. Invest. 38, 217–224, 1978.PubMedCrossRefGoogle Scholar
  25. 25.
    Muller, R. and Rajewsky, M.F. Cancer Res. 40, 887–896, 1980.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • James G. Lewis
    • 1
  • Mary A. Bedell
    • 1
    • 2
  • Kathyrn C. Billings
    • 1
    • 2
  • James A. Swenberg
    • 1
    • 2
  1. 1.Departments of PathologyDuke University Medical CenterDurhamUSA
  2. 2.Chemical Industry Institute of Toxicology, RTPUSA

Personalised recommendations