The Biological Disposition of Drugs and Inorganic Toxins

  • Edward K. Yeargers
  • Ronald W. Shonkwiler
  • James V. Herod


This chapter is a discussion of how some foreign substances get into the body, how they become distributed, what their effects are and how they are eliminated from the body. Lead is the exemplar in the biological discussion, but the biological concepts can be applied to many other substances. The mathematical discussion focuses on lead poisoning and on pharmaceuticals.


Periodic Solution Digestive Tract Liquid Fraction Chest Cavity Lead Poisoning 
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References and Suggested Further Reading

  1. 1.
    Lead poisoning: Ulrich Ewers and Hans-Werner Schlipkoter, “Lead,” pp. 971– 1014, in Metals and Their Compounds in the Environment, ed. Ernest Merian, VCH Publishers, Inc. New York, 1991.Google Scholar
  2. 2.
    Lead poisoning: The Chemical Environment, pp. 28–92, eds. John Lerihan and William W. Fletcher, Academic Press, 1977.Google Scholar
  3. 3.
    Lead poisoning: Michael B. Rabinowitz, George W. Wetherill and Joel D. Kopple, Science 182, 725–727, 1973.CrossRefGoogle Scholar
  4. 4.
    Lead poisoning: Henry A. Schroeder and Isabel H. Tipton, Arch. Environ. Healt 17, 956, 1968.Google Scholar
  5. 5.
    Embryology: Leland Johnson, Biology, William C. Brown, Publishers, Dubuque, Iowa, Second edition, 1987.Google Scholar
  6. 6.
    Biological organ systems: William S. Beck, Karel F. Liem and George Gaylord Simpson, Life — An Introduction To Biology, 3rd ed., Harper-Collins Publishers, New York, 1991.Google Scholar
  7. 7.
    Biological organ systems: Eldra Pearl Solomon, Linda R. Berg, Diana W. Martin and Claude Villee, BioloRy, 3rd ed., Saunders Colle2e Publishino. Fort Worth, 1991Google Scholar
  8. 8.
    Diffusion distances in cells: David Dusenbery, Sensory Ecology, Chapter 4, W. H. Freeman and Co., San Francisco, 1992.Google Scholar
  9. 9.
    Resistance to fluid flow: Steven Vogel, Life in Moving Fluids: The Physical Biology of Flow, Princeton University Press, Princeton, NJ, pp. 165–169, 1989.Google Scholar
  10. 10.
    Exponential of a matrix: “Nineteen dubious ways to compute the exponential of a matrix,” Moler and Van Loan, SIAM Review 20, no. 4, 1978.Google Scholar
  11. 11.
    Smog: E. Batschelet, L. Brand, and A. Steiner, J. Math. Biol. 8, 15–23, 1979.MathSciNetCrossRefGoogle Scholar
  12. 12.
    Computer modeling: Robert L. Borrelli, Courtney S. Coleman, William E. Boyce, Differential Equations Laboratory Workbook, John Wiley & Sons, Inc., New York, 1992.zbMATHGoogle Scholar
  13. 13.
    Pharmacokinetics: Edward Spitznagel, Two-Compartment Pharmacokinetic Mod els C-ODE-E, Fall, 1992 (published by Harvey Mudd College, Claremont, CA).Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Edward K. Yeargers
    • 1
  • Ronald W. Shonkwiler
    • 2
  • James V. Herod
    • 2
  1. 1.School of BiologyGeorgia Institute of TechnologyAtlantaUSA
  2. 2.School of MathematicsGeorgia Institute of TechnologyAtlantaUSA

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