A Biomathematical Approach to HIV and AIDS

  • Edward K. Yeargers
  • Ronald W. Shonkwiler
  • James V. Herod


Acquired Immunodeficiency Syndrome (AIDS) is medically devastating to its victims and wreaks financial and emotional havoc on everyone, infected or not. The purpose of this chapter is to model and understand the behavior of the causative agent of AIDS—the Human Immunodeficiency Virus (HIV). This will necessitate discussions of viral replication and immunology. By the end of this chapter the student should have a firm understanding of the way that HIV functions and be able to apply that understanding to a mathematical treatment of HIV infection and epidemiology.


Human Immunodeficiency Virus Host Cell Human Immunodeficiency Virus Infection Adaptive Immune System Snake Venom 
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References and Suggested Further Reading

  1. 1.
    Blood cells; immunity: William T. Keeton and James L. Gould, Biological Science, W.W. Norton and Company, New York, 5th ed., 1993.Google Scholar
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    Immunity: Special issue on the immune system: Scientific American, Vol. 269, No. 3, September, 1993.Google Scholar
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    HIV and AIDS: Martin A. Nowak and Andrew J. McMichael, “How HIV Defeats the Immune System,” in Scientific American, Vol. 273, No. 2, page 58, August, 1995.CrossRefGoogle Scholar
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    Mutations of HIV: Martin A. Nowak, Robert M. May and Roy M. Anderson, The evolutionary dynamics of HIV-I quasi species and the development of immunodeficiency disease, AIDS 1990 4, pp. 1095–1103, 1990.Google Scholar
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Edward K. Yeargers
    • 1
  • Ronald W. Shonkwiler
    • 2
  • James V. Herod
    • 2
  1. 1.School of BiologyGeorgia Institute of TechnologyAtlantaUSA
  2. 2.School of MathematicsGeorgia Institute of TechnologyAtlantaUSA

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