Cellular and Network Mechanisms in the Kindling Model of Epilepsy: The Role of GABAergic Inhibition and the Emergence of Strange Attractors

  • Fernando H. Lopes Da Silva
  • Willem Kamphuis
  • Jan M. A. M. Van Neerven
  • Jan Pieter M. Pijn


The kindling model of epilepsy offers the possibility of studying a number of general properties of the central nervous system: namely, (1) how plasticity or malleability in neuronal networks can be expressed and (2) how the system may become instable such that the ongoing activity is disrupted. The first point pertains to the question of synaptic plasticity, and the second point is related to the question of the maintenance or interruption of the flow of consciousness.


Neuronal Network Entorhinal Cortex Correlation Dimension Strange Attractor Population Spike 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Fernando H. Lopes Da Silva
  • Willem Kamphuis
  • Jan M. A. M. Van Neerven
  • Jan Pieter M. Pijn

There are no affiliations available

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