Kinins—II pp 555-567 | Cite as

Participation of Kallikrein, Coagulation/Fibrinolysis Parameters in the Development of Glomerulonephritis

  • Kazumichi Nakamura
  • Mutsuyoshi Kazama
  • Takeshi Abe
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


Masugi nephritis was induced in dogs in which platelet count, fibrinogen, antithrombin activity, plasma prekallikrein and immediate plasmin inhibitors were coincidentally decreased immediately after the injection of nephrotoxic serum. It was found that the grade of decrease of urinary kallikrein excretion following these immediate reactions were parallel with the grade of renal damages. By the pretreatment with heparin or the defibrination with snake venom, however, the histological findings of Masugi nephritis showed rather severe damage.

Based on the consumption of coagulation factors, kallikrein, kinin and their inhibitors in the development of this nephritis, it was postulated that inauguration of coagulation and activation of kallikrein contributed to the development of glomerulonephritis. The treatment or prevention of this coagulation process with heparin or snake venom, however, gave untoward effects on the pathological process in this experiment.


Snake Venom Coagulation Process Proliferative Glomerulonephritis Crescent Formation Antithrombin Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bone, J.M., A.J. Valdes, F.G. Germuth, Jr. and H. Lubowitz, 1975, Heparin therapy in anti-basement membrane nephritis, Kid. Intern. 8, 72.CrossRefGoogle Scholar
  2. Border, W.A., C.B. Wilson and F.J. Dixon, 1975, Failure of heparin to affect two types of experimental glomerulonephritis in rabbits, Kid. Intern. 8, 140.CrossRefGoogle Scholar
  3. Briggs, J.D., H.C. Kwaan and E.V. Potter, 1969, The role of fibrinogen in renal disease; III. Fibrinolytic and anticoagulant treatment of nephrotoxic serum nephritis in mice, J.Lab. Clin. Med. 74, 715.PubMedGoogle Scholar
  4. Cade, J.R., A.M. DeQuesada, D.L. Shires, D.M. Levin, R.L. Hackett, G.R. Spooner, E.M. Schlein, M.J. Pickering and A. Holcomb, 1971, The effect of long term high dose heparin treatment on the course of chronic proliferative glomerulonephritis, Nephron 8, 67PubMedCrossRefGoogle Scholar
  5. Cade, J.R., G.R. Spooner, E. Schlein, M. Pickering, A.M. DeQuesada A. Holcomb, L. Juncos, G. Richard, D. Shires, D. Levin, R. Hackett J. Free, R. Hunt and M. Fregly, 1973, Comparison of azathioprine, prednisone, and heparin alone or combined in treating lupus nephritis, Nephron 10, 37.PubMedCrossRefGoogle Scholar
  6. Glasser, R.J. and A.F. Michael, 1976, Urinary kallikrein in experimental renal disease, Lab. Invest. 34, 616.PubMedGoogle Scholar
  7. Halpern, B., P. Milliez, G. Lagrue, A. Fray and J.C. Morard, 1965, Protective action of heparin in experimental immune nephritis. Nature, 205, 257.PubMedCrossRefGoogle Scholar
  8. Kincaid-Smith, P., B.M. Saerand K.F. Fairley, 1968, Anticoagulants in irreversible acute renal failure, Lancet 2, 1360.PubMedCrossRefGoogle Scholar
  9. Kincaid-Smith, P., M.G. Laver, K.F. Fairley and D.C. Mathews, 1970, Dipyridamole and anticoagulants in renal disease due to glomerular and vascular lesions, Med. J. Aust. 1, 145.PubMedGoogle Scholar
  10. Kleinerman, J., 1954, Effect of heparin on experimental nephritis in rabbits, Lab. Invest. 3, 495.PubMedGoogle Scholar
  11. McGiven, A.R., 1967, Blood coagulation and the effect of Warfarin treatment on renal disease in NZB/NZW mice, Br. J. Exp. Pathol, 48, 552.PubMedCentralPubMedGoogle Scholar
  12. Michilson, P. and R. Verberckmoe, Treatment of proteinuria with an anti-inflammatory drug, 1966, in: Abstr. II. Int. Cong. Nephrol. ( Washington. D.C. ) P. 243.Google Scholar
  13. Naish, P.. G.B.. Penn. D.J. Evans and D.K. Peters, 1972, The effect defibrination on nephrotoxic serum nephritis in rabbits, Clin. Sci. 42. 643.PubMedGoogle Scholar
  14. Nakamura, K., 1977, The role of coagulation and fibrinolysis in the development of renal disease, Jap. J. Nephrol. 19, 947.Google Scholar
  15. Thomson, N.M., J. Moran, I.J. Simpson, 1976, Defibrination with ancrod in nephrotoxic nephritis in rabbit, Kid. Intern. 10, 343.CrossRefGoogle Scholar
  16. Vassalli, P1 and R.T. McCluskey, 1964-a, The pathogenetic role of fibrin deposition in immunologically induced glomerulonephritis, Ann. N.Y. Acad. Sci. 116, 1052.Google Scholar
  17. Vassalli., P. and R.T. McCluskey, 1964-b, the pathogenetic role of coagulation process in rabbit Masugi nephritis, Am. J. Path, 45, 653.Google Scholar
  18. Vassalli, P. and R.T. McCluskey, The pathogenetic role of the coagulation process in glomerular diseases of immunologic origin, 1971, in: Advances in Nephrology, Vol 1, eds. J. Hamburger, J. Crosnier and M.H. Maxwell ( Year Book Medical Publishers, Chicago ) p. 47.Google Scholar
  19. Werle, R., R. Busse and A. Schmal, 1968, Über die kallikrein-ausscheidung im Harn des Menschen nach Nierentransplantation Klin. Wochenschr. 49, 1315.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • Kazumichi Nakamura
    • 1
  • Mutsuyoshi Kazama
    • 1
  • Takeshi Abe
    • 1
  1. 1.Department of MedicineTeikyo University School of MedicineItabashi-ku, Tokyo 173Japan

Personalised recommendations